Changes in Learning and Memory in Pentylenetetrazole Induced Amnesia of Rats Treated with Lacosamide

Shishmanova, M.; Peychev, Lyudmil; Georgieva, Katerina

doi:10.15373/2249555x/jan2014/13

Cited by 1 publication

(1 citation statement)

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“…One of the possible mechanisms inducing this effect is the reduction by LCM of BDNF expression and its tropomyosin receptor kinase B (TrkB) receptor in the hippocampus [54]. Treatment with LCM has been shown to be effective in restoring rats' learning and memory abilities after PTZ-induced epilepsy [55]. It is also worth mentioning studies by Meador et al [56] which showed that healthy adult patients experienced less cognitive impairment during LCM treatment compared to carbamazepine treatment.…”

Section: Discussionmentioning

confidence: 99%

Effect of Lacosamide and Ethosuximide Chronic Treatment on Neural Precursor Cells and Cognitive Functions after Pilocarpine Induced Status Epilepticus in Mice

et al. 2021

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Seizures in about 40% of patients with epilepsy fail to respond to anti-seizure medication (ASM) and may lead to uncontrolled and prolonged seizures often inducing status epilepticus (SE). The aim of the study was to evaluate the impact of a long-term treatment with two different generation ASMs: ethosuximide (ETS, a classic ASM) and lacosamide (LCM, a 3rd generation ASM) on neural stem cells’ (NSCs’) proliferation and learning and memory functions after pilocarpine (PILO)-induced SE in mice. The following drugs were used: LCM (10 mg/kg), ETS (20 mg/kg), and PILO (300 mg/kg). Cell counting was done using confocal microscope and ImageJ software. Cognitive functions were evaluated with the Morris water maze (MWM) test. The level of several selected neurometabolites was measured with magnetic resonance spectroscopy (MRS). Obtained results indicated no significant impact of ETS treatment on the neurogenesis process in PILO mice. Interestingly, LCM significantly decreased the total amount of newborn neurons. The MWM test indicated no significant changes in the time and distance traveled by the ETS and LCM groups compared to PILO control mice, although all measured parameters were more favorable for the PILO mice treated with ASM. Conclusions: The presented results show that long term treatment with LCM and ETS seems to be safe for the cognitive functions and the proper course of neurogenesis in the mouse PILO-induced SE model, although one should remember that LCM administered chronically may act to reduce new neurons’ formation.

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Section: Discussionmentioning

confidence: 99%