Changes in laryngopharyngeal reflux after uvulopalatopharyngoplasty for obstructive sleep apnea: An observational study

Tang, Xiaojun; Tang, Qinglai; Li, Shisheng; Yang, Xinming; Zhang, Ying; Zeng, Shiying; Huang, Peiying; Li, Mengmeng

doi:10.1002/lio2.718

Cited by 3 publications

(4 citation statements)

References 34 publications

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“…Eine weitere Ursache des OSAS kann ein meist unbemerkter nächtlicher Laryngopharyngealreflux (LPR) sein 24 , 25 . Es konnte gezeigt werden, dass bei 12% der Refluxpatienten gleichzeitig ein OSAS vorlag, wohingegen dies nur bei 5% der Patienten ohne Reflux der Fall war.…”

Section: Pathophysiologieunclassified

Pathophysiologie der Schlafapnoe

Hohmann¹

2023

Erfahrungsheilkunde

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ZusammenfassungObstruktiven Schlafapnoen liegen meist mechanische Ursachen zugrunde. Zumeist handelt es sich um Fettablagerungen in den oberen Atemwegen sowie um eine Verringerung des Lungenvolumens, was zu einem Verlust der kaudalen Traktion der oberen Atemwege führt. Aufgrund des Umstands, dass 60–80% der Betroffenen eine Ernährungsstörung im Sinne einer Adipositas aufweisen, rücken adipöse und darmgestörte Patienten in den Vordergrund. Auch wenn die gesamten Zusammenhänge noch nicht vollständig erforscht sind, zeigt sich, dass der bei Adipösen stark vergrößerte Anteil an viszeralem Fett als endokrines Organ zur Pathogenese der obstruktiven Schlafapnoe beiträgt. Weitere Ursachen der obstruktiven Schlafapnoe können ein meist unbemerkter nächtlicher laryngopharyngealer Reflux sowie intestinale Intoxikationen sein. Der Beitrag beleuchtet die Pathophysiologie der Schlafapnoen unter ernährungs- und darmspezifischen Aspekten und beschreibt davon ausgehende Therapieansätze außerhalb der bekannten konventionellen Verfahren.

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Section: Pathophysiologieunclassified

Pathophysiologie der Schlafapnoe

Hohmann¹

2023

Erfahrungsheilkunde

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“…Overall, significant decreases in mean RSI score were observed after CPAP treatment. It was also shown that uvulopalatopharyngoplasty (UPPP) can improve RSI score, potentially by alleviating upper airway collapse and corresponding pulse of negative intrathoracic pressure and positive abdominal pressure [ 90 ]. OSA and acid reflux may also be the contributors to chronic cough in patients with OSA and concomitant acid reflux [ 91 ].…”

Section: Acid Reflux – Chronic Cough – Dysphagiamentioning

confidence: 99%

More than sleepiness: prevalence and relevance of nonclassical symptoms of obstructive sleep apnea

Verbraecken¹

2022

Current Opinion in Pulmonary Medicine

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Purpose of reviewThe purpose of this review is to describe the nonclassical symptoms and manifestations occurring in patients with obstructive sleep apnea (OSA), both from a standpoint of prevalence and in terms of clinical relevance. Particular emphasis will be given to nightmares, comorbid insomnia, restless legs syndrome and periodic limb movement disorder, bruxism, morning headache, nocturia, acid reflux, chronic cough and dysphagia. Recent findingsA review of the recent literature suggests that nonclassical symptoms have a high prevalence, are underestimated, and can interact with quality of life. Although these disturbances may occur together by mere coincidence, they may interact reciprocally. However, the degree of symptoms is not always correlated with OSA severity. SummaryOSA is a heterogeneous disease with variable clinical manifestations. This review highlights the need for detailed evaluation of patients with OSA to diagnose other important sleep disorders and clinical manifestations, given their frequent association.

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“…Ten articles 9,22,24,26,29,33,36,39,42,43 compared the clinical characteristics of patients with LPR-positive OSAHS and LPR-negative OSAHS (Table 2). Six studies 10,25,[27][28][29]36 provided Spearman's or Pearson's CORs between RSI score and AHI score. Four studies 8,25,27,28 provided Spearman's or Pearson's CORs between RSI and AHI scores.…”

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confidence: 99%

“…Six studies 10,25,[27][28][29]36 provided Spearman's or Pearson's CORs between RSI score and AHI score. Four studies 8,25,27,28 provided Spearman's or Pearson's CORs between RSI and AHI scores. Figure 1 represents the Preferred Reporting Items for Systematic Reviews and Meta-Analyses flow diagram for selecting and screening articles from the literature.…”

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confidence: 99%

Laryngopharyngeal Reflux in Obstructive Sleep Apnea-Hypopnea Syndrome: An Updated Meta-Analysis

He¹,

Wang²,

Li³

2022

NSS

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Laryngopharyngeal reflux (LPR) is a common disorder in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS). This meta-analysis was carried out to evaluate the LPR prevalence in individuals with OSAHS and to analyze the correlation of LPR positivity with the clinical features of patients with OSAHS. A detailed review of the English and Chinese literature on the occurrence of LPR in patients with OSAHS was performed by employing online search tools such as PubMed, EMBASE, Web of Science, VIP, CNKI, WanFang, etc. Two researchers analyzed the studies for quality according to the STROBE standard checklist. The acquired data were analyzed using Stata 11.0 and R 3.6.1 software. The effect size was estimated and calculated using weighted mean difference (WMD) and correlation coefficients. Moreover, a combined analysis was performed by employing either a random-or fixed-effects model. Ultimately, 27 studies met our inclusion criteria. Our study revealed that the LPR prevalence in OSAHS patients was 49%. We carried out subgroup analyses as per OSAHS severity, ethnicity, and body mass index (BMI). The results suggested that the probability of LPR in European and American patients with OSAHS was higher, and the prevalence of LPR was higher in obese individuals and patients with severe OSAHS. Moreover, apnea-hypopnea index (AHI) and BMI were higher in LPR-positive OSAHS patients than in LPR-negative OSAHS patients, but no significant variation in age was observed in the two groups. Moreover, the reflux symptom index (RSI) scores and the reflux finding score (RFS) exhibited a positive correlation with AHI. The current literature shows a higher incidence of LPR in individuals with OSAHS (49%). The severity of AHI in individuals with OSAHS is associated with the presence of LPR. Patients with OSAHS accompanied by LPR showed higher BMI and AHI as compared to those patients with LPR-negative OSAHS.

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Changes in laryngopharyngeal reflux after uvulopalatopharyngoplasty for obstructive sleep apnea: An observational study

Cited by 3 publications

References 34 publications

Pathophysiologie der Schlafapnoe

Pathophysiologie der Schlafapnoe

More than sleepiness: prevalence and relevance of nonclassical symptoms of obstructive sleep apnea

Laryngopharyngeal Reflux in Obstructive Sleep Apnea-Hypopnea Syndrome: An Updated Meta-Analysis

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