Changes in Laminin in Acute Heart Failure

Wang, Jing; Xie, Ling; Chen, Xiangfan; Lyu, Ping; Zhang, Qing

doi:10.1536/ihj.21-769

Cited by 2 publications

(2 citation statements)

References 20 publications

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“… 74 Laminin is a major component of the cardiac basement membrane and is known to be elevated during cardiac fibrosis. 75 In contrast, pericardial macrophages expressed the dimer αVβ3, which is the vitronectin receptor and binds to the RGD sequence (arg-gly-asp) common across many extracellular matrix proteins including fibronectin, vitronectin and fibrinogen. 76 , 77 These differing extracellular matrix (ECM) binding affinities suggest that pericardial macrophages might not be attuned to the myocardial environment, lacking the primary integrins expressed by their myocardial counterpart therefore making them poorly suited to migrate to the myocardium.…”

Section: Discussionmentioning

confidence: 99%

The protective role of GATA6+ pericardial macrophages in pericardial inflammation

Hughes,

Won,

Talor

et al. 2024

iScience

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Section: Discussionmentioning

confidence: 99%

The protective role of GATA6+ pericardial macrophages in pericardial inflammation

Hughes,

Won,

Talor

et al. 2024

iScience

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“…99 Laminin (including LAMC1) protein levels differ in patients with and without atrial fibrillation. 100,101 LAMC1 gene implicated in arrhythmia. 102 Laminins (including LAMC1) important in regulation of heart looping, atrial growth and cardiac size during development.…”

Section: Extracutaneous Phenotypementioning

confidence: 99%

X‐linked ichthyosis: New insights into a multi‐system disorder

Wren

Davies

2022

Skin Health and Disease

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Background X‐linked ichthyosis (XLI) is a rare genetic condition almostexclusively affecting males; it is characterised by abnormal desquamation and retentionhyperkeratosis, and presents with polygonal brown scales. Most cases resultfrom genetic deletions within Xp22.31 spanning the STS (steroid sulfatase)gene, with the remaining cases resulting from STS‐specific mutations. For manyyears it has been recognised that individuals with XLI are at increased risk ofcryptorchidism and corneal opacities. Methods We discuss emerging evidence that such individuals are alsomore likely to be affected by a range of neurodevelopmental and psychiatrictraits, by cardiac arrhythmias, and by rare fibrotic and bleeding‐relatedconditions. We consider candidate mechanisms that may confer elevatedlikelihood of these individual conditions, and propose a novel commonbiological risk pathway. Results Understanding the prevalence, nature and co‐occurrence ofcomorbidities associated with XLI is critical for ensuring early identificationof symptoms and for providing the most effective genetic counselling andmultidisciplinary care for affected individuals. Conclusion Future work in males with XLI, and in new preclinical andcellular model systems, should further clarify underlying pathophysiologicalmechanisms amenable to therapeutic intervention.

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Changes in Laminin in Acute Heart Failure

Cited by 2 publications

References 20 publications

The protective role of GATA6+ pericardial macrophages in pericardial inflammation

The protective role of GATA6+ pericardial macrophages in pericardial inflammation

X‐linked ichthyosis: New insights into a multi‐system disorder

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