Changes in laboratory markers of thrombotic risk early in the first trimester of pregnancy may be linked to an increase in estradiol and progesterone

The freeze-all strategy after IVF: which indications?

“…The change in the E2 level between baseline and hyperstimulation correlates with changes in APC (Curvers et al, 2001). More recently, early changes in laboratory markers of thrombotic risk (especially thrombin generation) in the first trimester of pregnancy have been evaluated in women undergoing natural cycle IVF (Bagot et al, 2019). This study confirmed the correlation between high estradiol and progesterone levels and markers of hypercoagulability.…”

“…This study confirmed the correlation between high estradiol and progesterone levels and markers of hypercoagulability. Moreover, the results showed that the prothrombotic state developed very early during the first trimester (Bagot et al, 2019).…”

Coagulation challenges in pregnancy: from thrombophilia involvement and management to the utility of thrombin generation monitoring

“…Plasma mean StartTail time, peak thrombin generation and endogenous thrombin potential increased significantly in the first trimester of pregnancy and remained stable in the next two trimesters in a Chinese study [20]. Indeed, an increase of velocity index, peak thrombin and endogenous thrombin potential at the 32 nd day of gestation [21] and at the 43 rd day of gestation [22], compared to pre-pregnancy values, have been observed in two studies done in the U.K. These increased values persisted through to the 59 th day of gestation [22].…”

“…Serum levels of estradiol and progesterone were also significantly higher by day 32 of gestation. This suggests that these two hormones are linked to the prothrombotic state of pregnant women [21]. Regarding the level of D-dimer and factor VIII, they increased in the 59 th day of gestation compared to pre-pregnancy levels [3].…”

Trombose vascular periférica no período gestacional

“…Julga-se que, principalmente, a exposição do estrogênio de maneira exógena possa alterar na transcrição de fatores da coagulação, conferindo uma maior ameaça no que diz respeito a formação de trombos para mulheres que faziam uso de anticoncepcionais (AC) ou Reposição Hormonal (RH) anteriormente a gestação. A progestina confere risco diminuído a eventos tromboembólicos, podendo ser uma alternativa segura no controle da natalidade para mulheres com histórico de TEV, porém o autor ressalta a importância do acompanhamento médico individualizado para esses casos, bem como, ao uso de tromboprofilaxia nessas ocasiões (James, 2017;Bagot et al, 2019).…”