Changes in Knot-Holding Capacity of Sliding Knots In Vivo and Tissue Reaction

In vitro Comparison of Secure Aberdeen and Square Knots with Plasma- and Fat-Coated Polydioxanone

“…Tissue reactivity to sutures is most pronounced at the knot, because knots cause the greatest amount of trauma to adjacent tissue layers and have the highest density of foreign material within the suture line 20 . Increasing a knot's volume by adding additional throws or increasing suture size will add more foreign body in a wound thus generating a greater amount of tissue reaction 20,21 . This may lead to increased morbidity, 5,22 an increased inflammatory phase 20 and may increase the risk of self mutilation.…”

“…20 Increasing a knot's volume by adding additional throws or increasing suture size will add more foreign body in a wound thus generating a greater amount of tissue reaction. 20,21 This may lead to increased morbidity, 5,22 an increased inflammatory phase 20 and may increase the risk of self mutilation. Additionally large bulky knots cause pain and can lead to sinus tract formation in abdominal closures.…”

Laser soldering of rat skin, using fiberoptic temperature controlled system

“…For the control group, two cuts were sutured with simple interrupted 4±0 silk (19 HH cutting needle, Sherwood Medicals, Norfolk Nebraska). Silk was chosen over other nonabsorbable sutures because of its less itching and more reliable knot [18] properties, assuming it will cause less self-scratching of the rats back. After the operation, the wounds were left uncovered and the rats were housed separately to prevent them from licking and biting each other's wounds.…”

Comet-Tail-Like Inflammatory Infiltrate to Polymer Filaments Develops in Tension-Free Conditions

“…In a bid to find the ideal textile fibre for suture materials, numerous clinical and experimental studies investigated intrinsic biocompatibility, physical and clinical features, knotting type and tissue reaction. In the majority of these studies tension was applied to the suture [9,10,11,12]. However, Postlethwaite et al [13 ]already noted acellular fibrous tissue on the side of the suture toward the tension; while opposite to the direction of tension there resulted a cellular infiltrate marking the path of the migrating and thus cutting action.…”