Changes in interleukin 6 and monocyte chemoattractant protein-1 expression levels in 3t3-l1 cells after exposure to agrimonia eupatoria l. extract and subsequent oxidative stimulation with tert-buthyl hydroperoxide reveal possible adaptogenic potential

Kiselova, Yoana; Vankova, Deyana; Tasinov, Oskan; Feklicheva, Inna; Potoroko, Irina; Ivanova, Diana

doi:10.14748/ssp.v4i2.4337

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“…Phytochemical characterization reveals that components such as epigallocatechin, hydroxyphenylacetate, ferulic acid, caffeic acid and especially neohesperidin and epicatechin predominate in aerial part extract [17]. Leaves are also rich in agrimoniin, apigenin-7-Oglucuronide and apigenin-6-C-glucoside [22]. The aim of this study was to assess the possibility to modulate with agrimony tea intake serum lipid parameters and adipose gene expression in a model of rats supplemented with fructose.…”

Section: Serum Lipid Parameterstotal Cholesterol (Tc) and Triglycerid...mentioning

confidence: 99%

Fructose Induced Changes in Rat Serum Lipids and Adipose Tissue Gene Expression and Preventive Effects of Agrimonia Eupatoria Aqueous Infusion Intake

Kiselova-Kaneva¹

2023

FARMACIA

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Potential of various herbs in regard to their ability to counteract obesity and related metabolic disturbances has been extensively studied. The aim of the current study was to assess the potential of Agrimonia eupatoria aqueous infusion (AE) to counteract fructose induced changes in serum total cholesterol (TC) and triglycerides (TG), the ratio of retroperitoneal adipose tissue weight/body weight and adipose tissue gene expression of the proteins Lipe, Fasn, Dgat, Hmgcr and adipokines AdipoQ and Plin. Twenty-four male Wistar rats were equally divided in to four groups -standard diet (ST); standard diet with AE (ST+AE); fructose overloaded (FR); fructose overloaded with AE (FR+AE). FR group showed significantly higher levels of TC, TG and adipose tissue weight relative to other groups. AE administration resulted in lower TC and TG levels, as compared to ST group (0.93 ± 0.43 mmol/L vs. 1.29 ± 0.57 mmol/L, p < 0.05 and 0.59 ± 0.1 vs. 0.91 ± 0.17 mmol/L, p < 0.001, respectively). Similarly, TC and TG were decreased also in ST+AE group (0.47 ± 0.21 mmol/L vs. 0.87 ± 0.57 mmol/L, p < 0.01 and 0.77 ± 0.15 vs. 0.92 ± 0.25 mmol/L, p < 0.05, respectively) in comparison to ST group. Gene expression analysis revealed a significant increase in Lipe (2.35 fold change, p < 0.05) and Hmgcr (2.86 fold change, p < 0.05) and a decrease (83%, p < 0.001) in Fasn mRNA levels in the FR group. AE consumption contributed to a significant decrease in the expression of Dgat2 (56%, p < 0.05) and Hmgcr (0.52%, p < 0.05) in Fr+AE group and of Fasn (71%, p < 0.001) in the ST+AE group. In conclusion, recent study demonstrated that Agrimonia eupatoria aqueous infusion intake improved total cholesterol and triglycerides imbalance in Wistar rats and modulated adipose tissue gene expression, which indicated that the herb might exert its favourable effects on adipose tissue possibly by preventing triglyceride synthesis and inducing mobilization of stored TG. RezumatÎn general, potențialul terapeutic al diferitelor plante pentru combaterea obezității și al dezechilibrelor metabolice asociate este intens studiat. Scopul prezentului studiu a fost de a evalua capacitatea infuziei apoase de Agrimonia eupatoria (AE) de a echilibra modificările induse de fructoză asupra valorilor colesterolului total (TC) și trigliceridelor (TG) din ser, de a echilibra raportul masă țesut adipos retroperitoneal/masă corporală, și de a modula expresia genelor pentru proteinele Lipe, Fasn, Dgat, Hmgcr și adipokinele AdipoQ și Plin din țesutul adipos. Douăzeci și patru de șobolani albi Wistar au fost împărțiți în patru loturi, care au primit următoarele diete: dietă standard (ST); dietă standard cu AE (ST+AE); supliment de fructoză (FR); supliment de fructoză cu AE (FR+AE). Lotul FR a prezentat nivele semnificativ crescute ale TC, TG și ale masei de țesut adipos, comparativ cu celelalte loturi. Administrarea de AE a condus la o scădere a valorilor TC şi TG comparativ cu lotul ST (0,93 ± 0,43 mmol/L față de 1,29 ± 0,57 mmol/L, p < 0,05 și, respectiv 0,59 ± 0,1 față de 0,91 ±...

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Section: Serum Lipid Parameterstotal Cholesterol (Tc) and Triglycerid...mentioning

confidence: 99%

Fructose Induced Changes in Rat Serum Lipids and Adipose Tissue Gene Expression and Preventive Effects of Agrimonia Eupatoria Aqueous Infusion Intake

Kiselova-Kaneva¹

2023

FARMACIA

View full text Add to dashboard Cite

show abstract

Changes in interleukin 6 and monocyte chemoattractant protein-1 expression levels in 3t3-l1 cells after exposure to agrimonia eupatoria l. extract and subsequent oxidative stimulation with tert-buthyl hydroperoxide reveal possible adaptogenic potential

Cited by 1 publication

References 0 publications

Fructose Induced Changes in Rat Serum Lipids and Adipose Tissue Gene Expression and Preventive Effects of Agrimonia Eupatoria Aqueous Infusion Intake

Fructose Induced Changes in Rat Serum Lipids and Adipose Tissue Gene Expression and Preventive Effects of Agrimonia Eupatoria Aqueous Infusion Intake

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