Changes in insulin and lipid metabolism in males with asymptomatic hyperuricaemia

Zavaroni, Ivana; Mazza, Stefania; Fantuzzi, M.; Dall’Aglio, Elisabetta; Bonora, Enzo; Delsignore, R; Passeri, M; Reaven, Gerald M.

doi:10.1111/j.1365-2796.1993.tb00700.x

Cited by 111 publications

(60 citation statements)

References 29 publications

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“…24 Finally, it should be pointed out that the positive relationship between insulin resistance and poxLDL was seen in this study, despite the presumptive protective effect of the higher uric acid concentrations that are characteristic of subjects with syndrome X. 32,33 Thus, there appear to be several potential means by which the various components of syndrome X could modify LDL oxidative status.…”

Section: Discussionmentioning

confidence: 80%

Relationship Between Insulin Resistance and Partially Oxidized LDL Particles in Healthy, Nondiabetic Volunteers

Carantoni

Abbasi

Warmerdam

et al. 1998

ATVB

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Abstract-This study was performed in 36 healthy volunteers to define the relationship between plasma concentrations of partially oxidized low density lipoprotein (poxLDL), plasma glucose and insulin responses to oral glucose, and steady-state plasma glucose (SSPG) concentrations after a 180-minute infusion of somatostatin, insulin, and glucose. The concentration of poxLDL was estimated by determining the amount of conjugated dienes formed during in vitro LDL oxidation in the presence or absence of alanine. Under these conditions, the greater the in vitro antioxidant effect of alanine, the lower the amount of poxLDL that was present in plasma. Key Words: oxidized LDL Ⅲ insulin resistance Ⅲ cardiovascular disease risk factors P revious reports from our laboratory have emphasized the potential link between insulin resistance, a cluster of associated abnormalities, and atherosclerosis in nondiabetic subjects.1,2 An important component of the metabolic abnormalities associated with insulin resistance is a change in LDL particle diameter, leading to the presence of smaller and denser LDL particles.3 Given the fact that such particles are more easily oxidized, 4 it seemed to be of great interest to know whether there were any associations between insulin resistance and the oxidative states of circulating LDL. Approaching this problem is complicated by the fact that oxLDL has been detected in the arterial wall, but not in the circulation.5 LDL oxidation has usually been assessed by determining the formation of thiobarbituric acid-reactive compounds or by the lag time for conjugated-diene formation during copper oxidation-methods that do not permit determination of the oxidized state of LDL present in the circulation. 6 In an effort to overcome this problem, Picard et al 7 have described a sensitive and reproducible method to quantify the oxidized state of LDL present in the circulation on the basis of the antioxidant properties of alanine. This effect of alanine depends on the amount of peroxides present in LDL and the fact that the greater the amount of peroxides in LDL, the less the antioxidant effect of alanine. Thus, by quantifying the antioxidant effect of alanine on isolated LDL, it is possible to gain an estimate of the amount of poxLDL that is present in the circulation. Picard et al 7 used this method to show that LDL oxidation was increased in patients with type 2 diabetes who had evidence of atherosclerosis but absent in diabetic subjects with no apparent vascular disease. Since there is increasing evidence 1,2,8 that insulin resistance or compensatory hyperinsulinemia is associated with a variety of CHD risk factors, we initiated the current study to see whether there was any relationship between the resistance of insulinmediated glucose disposal or the metabolic variables associated with insulin resistance and the amount of poxLDL in nondiabetic volunteers, all of whom were in general good health. MethodsThe study population consisted of 36 healthy volunteers, 14 men and 22 women, who responded to a newspap...

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Section: Discussionmentioning

confidence: 80%

Relationship Between Insulin Resistance and Partially Oxidized LDL Particles in Healthy, Nondiabetic Volunteers

Carantoni

Abbasi

Warmerdam

et al. 1998

ATVB

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“…8,[17][18][19] Although steatosis alone is thought to be a benign condition, the development of nonalcoholic steatohepatitis (NASH) can lead to liver cirrhosis or hepatoma. Therefore it is important to diagnose NAFLD early in its development.…”

Section: Discussionmentioning

confidence: 99%

Serum Uric Acid as a Predictor for the Development of Nonalcoholic Fatty Liver Disease in Apparently Healthy Subjects: A 5-Year Retrospective Cohort Study

Lee¹,

Cho²,

Ryan³

et al. 2010

Gut Liver

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Background/Aims: This study evaluated the relationship between hyperuricemia and nonalcoholic fatty liver disease (NAFLD) by comparing the incidence rates of NAFLD in relation to serum uric acid levels in apparently healthy subjects during a 5-year period. Methods: Among 15,638 healthy Korean subjects who participated in a health-screening program in 2003 and 2008, respectively, 4954 subjects without other risk factors were enrolled in this study. We compared the incidence rates of NAFLD in 2008 with respect to baseline uric acid levels. Results: In 2003, serum uric acid levels were categorized into the following quartiles: 0.6-3.9, 3.9-4.8, 4.8-5.9, and 5.9-12.6 mg/dL. The incidence of NAFLD in 2008 increased with the level of baseline uric acid (5.6%, 9.8%, 16.2%, and 20.9%, respectively; p＜0.05). Multiple logistic regression analysis demonstrated that hyperuricemia was associated with the development of NAFLD. When compared to the subjects in quartile 1, the odds ratio (OR) for the incidence of NAFLD for quartiles 2, 3, and 4 were 1.

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“…3 This is supported by the finding that increased serum uric acid levels are related to decreased insulin-stimulated glucose uptake and increased plasma insulin response to oral glucose loading. [14][15][16] It should be noted that preventing hyperuricemia by controlling alcohol consumption and controlling body weight could lead to preventing these diseases.…”

Section: Methodsmentioning

confidence: 99%

“…1,2 Besides gout, hyperuricemia has been associated with other diseases and conditions such as diabetes, hyperlipidemia, hypertension, and other cardiovascular diseases. [3][4][5][6][7][8][9][10][11][12][13][14][15][16] In addition, some epidemiologic studies have suggested that hyperuricemia affects overall mortality, and that serum uric acid is a considerable risk factor for reduced life expectancy. 17,18 Many previous studies have pointed out the risk factors for hyperuricemia.…”

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confidence: 99%

The Effect of Alcoholic Beverage Type on Hyperuricemia in Japanese Male Office Workers

Sugie

Imatou

Miyazaki

et al. 2005

Journal of Epidemiology

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(Hitachi 7350) by the uricase method. Statistical analysisFor statistical analysis, we took two steps. First, logistic regression analysis was performed to assess the relationship between alcohol intake and high serum uric acid level. Odds ratios were calculated from a multivariate models adjusted for age, BMI, intake of snacks, and smoking habits. In this analyses, among 715 subjects, cases were subjects whose serum uric acid levels were 7.0+ mg/dL (n=183) because hyperuricemia is defined as a serum uric acid level of 7.0 mg/dL or higher, without regard to sex or age, by the Japanese Society of Gout and Nucleic Acid Metabolism.29 Controls were subjects whose serum uric acid levels were less than 6.0 mg/dL (n=328) because the Japanese Society of Gout and Nucleic Acid Metabolism recommended to control the serum uric acid level less than 6.0mg/dL. 29 Second, we investigated the relationships between the alcoholic beverage type and high serum uric acid levels. Logistic regression analysis was also performed to adjust the effects of age, alcohol intake, BMI, intake of snacks, and smoking habits. In these analyses, among 385 subjects who were regular drinkers and identified one main alcoholic beverage consumed, cases were subjects whose serum uric acid levels were also 7.0+ mg/dL (n=121) and controls were subjects whose serum uric acid levels were less than 6.0 mg/dL (n=148). All data were analyzed with SPSS ® Base 11.5J for Windows (SPSS Inc., Chicago, IL, USA).

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Changes in insulin and lipid metabolism in males with asymptomatic hyperuricaemia

Cited by 111 publications

References 29 publications

Relationship Between Insulin Resistance and Partially Oxidized LDL Particles in Healthy, Nondiabetic Volunteers

Relationship Between Insulin Resistance and Partially Oxidized LDL Particles in Healthy, Nondiabetic Volunteers

Serum Uric Acid as a Predictor for the Development of Nonalcoholic Fatty Liver Disease in Apparently Healthy Subjects: A 5-Year Retrospective Cohort Study

The Effect of Alcoholic Beverage Type on Hyperuricemia in Japanese Male Office Workers

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