“…Central symptoms, or symptoms with a large number of connections to other symptoms in a network, represent core features of a syndrome [35], and can, theoretically, be considered targets for widespread symptom reduction [38]. Network analysis has been used to characterize symptom presentation and progression in schizophrenia [39], depression, anxiety [40], post-traumatic stress disorder [41], and sport-related concussion [42][43][44]. Three studies have used network analysis to characterize NPS within clinical memory samples [8,31,45], evaluating frequent and central symptoms [31], longitudinal stability of clinical presentation [45], and the relationship of NPS to adaptive functioning in AD [8].…”