Changes in histological criteria lead to different prevalences of nonalcoholic steatohepatitis in severe obesity

Low clinical relevance of the nonalcoholic fatty liver disease activity score (NAS) in predicting fibrosis progression

“…In a study of 111 severely obese patients with NAFLD, the prevalence of NASH decreased from 55.5 to 25.3% when two different criteria were used [22]. In another study, the agreement between the definition of NASH as described by Matteoni et al [23] and the NAS was 0.77.…”

The Epidemiology of Nonalcoholic Fatty Liver Disease: A Global Perspective

“…On average, these studies reported that 76% (range 33 to 99%) of the patients undergoing bariatric surgery have steatosis, 37% (range 9.8 to 72.5%) have NASH, 23% (range 7.3 to 49%) fibrosis, and 5.8% (range 1.6 to 10%) cirrhosis. [69][70][71][72][73][74][75][76][77][78][79][80][81][82][83][84][85] People with Type 2 Diabetes Several studies have described a higher prevalence of NAFLD among people with type 2 diabetes compared with nondiabetics, with prevalence estimates ranging from 40% to 69.5%. 61,86,87 Moreover, a recent casecontrol study using proton-MRS demonstrated that people with type 2 diabetes have on average 80% more liver fat than age-, weight-, and sex-matched controls.…”

Enhanced serum concentrations of transforming growth factor-beta1 in simple fatty liver: is it really benign?

“…Diagnosis of NAFLD can usually be done by imaging studies in absence of other liver disease. Liver biopsy is required to size disease severity (inflammation, degenerative lesion and fibrosis), even though some limitations cast doubts on its use in clinical settings [ 1 ].…”