Changes in hemorheological and biochemical parameters following short-term and long-term smoking cessation induced by nicotine replacement therapy (NRT)

Ko, Haustein; Krause, J; Haustein, Heidi; Rasmussen, Thomas; Cort, N.

doi:10.5414/cpp42083

Cited by 35 publications

(22 citation statements)

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“…In a study with NRT, the abstainers and smoking reducers had a greater reduction in WBC count after 6 months. 43,44 In line with those earlier findings, we also observed a significant decrease in WBC count. Interestingly, the WBC count decreased in both abstainers and relapsers, and these results did not change even when controlled for nicotine intake or exercise adherence, suggesting that the combination of the cessation program that led to either complete abstinence or reduction in smoking had a beneficial effect on this biomarker.…”

Section: Discussionsupporting

confidence: 82%

“…44 We observed some increase in HDL-C among abstainers and an increase among relapsers in triglycerides. These differences did not reach statistical significance.…”

Section: Discussionmentioning

confidence: 73%

“…It may be that our follow-up period was not long enough to detect these changes, as some of them were observed at 6 months postcessation. 44 Among hemodynamic factors, HR decreased among the participants, but it was more profound among the abstainers than among those who relapsed. Our results support previous findings indicating HR normalization even if NRT is being used.…”

Section: Discussionmentioning

confidence: 99%

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Smoking Cessation Program with Exercise Improves Cardiovascular Disease Biomarkers in Sedentary Women

Korhonen

Goodwin

Miesmaa

et al. 2011

Journal of Women's Health

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Background: Several cardiovascular disease (CVD) biomarkers sensitive to tobacco exposure have been identified, but how tobacco use cessation impacts them is less clear. We sought to investigate the effects of a smoking cessation program with an exercise intervention on CVD biomarkers in sedentary women. Methods: This is a cohort study on a subsample of a 2 · 2 factorial randomized controlled trial (RCT) (exercise setting: home vs. facility; level of exercise counseling: prescription only vs. prescription and adherence counseling) conducted January 2004 through December 2007. The analyses were completed in October 2010. In the greater Boston area, 130 sedentary female smokers aged 19-55 completed a 15-week program. All participants received nicotine replacement therapy (transdermal patch) and brief behavioral counseling for 12 weeks. They all received an exercise prescription on a moderate intensity level. All exercise interventions lasted for 15 weeks, from 3 weeks precessation until 12 weeks postcessation. Main outcome measures were selected CVD biomarkers hypothesized to be affected by smoking cessation or exercise measured at baseline and 12 weeks postcessation. Results: Independent of tobacco abstinence, improvement was seen in inflammation (white blood cells [WBC]), prothrombotic factor (red blood cells [RBC]), and cardiovascular fitness level (maximum oxygen consumption [Vo 2 max]). This suggests that even if complete abstinence is not achieved, reduction in tobacco exposure and increase in exercise can improve the cardiovascular risk profile. A significant decrease was seen for total cholesterol and the total cholesterol high-density lipoprotein cholesterol (HDL-C): ratio only among the abstainers. The heart rate was reduced among all participants, but this decrease was more profound among abstainers. A significant weight gain and body mass index (BMI) increase were observed among abstainers and those who relapsed. We also found an increase in hemoglobin A1c (Hb A1c), although significant only when the groups were combined. Conclusions: A smoking cessation intervention including exercise reduced tobacco-induced cardiovascular damage selectively within 3 months.

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Section: Discussionsupporting

confidence: 82%

“…44 We observed some increase in HDL-C among abstainers and an increase among relapsers in triglycerides. These differences did not reach statistical significance.…”

Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 99%

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Smoking Cessation Program with Exercise Improves Cardiovascular Disease Biomarkers in Sedentary Women

Korhonen

Goodwin

Miesmaa

et al. 2011

Journal of Women's Health

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“…This was reflected in this work, the whole blood viscosity (WBV) and Packed Cell Volume (PCV) were not statistically significant but experimental differences were noticed in the results. The whole blood viscosity of smokers was slightly higher than that of non-smokers and this was in agreement with the previous work done (Haustein et al, 2004). Smoking is associated with an increase in haematocrit (PCV) or red blood cell mass, this was also noticed in this work and the increased may be attributable to increased level of carbon monoxide (CO) and carboxyhaemoglobin.…”

Section: Discussionsupporting

confidence: 92%

Evaluation of Haemorheological Parameters in Cigarette Smokers in Western Nigeria

Oke¹,

Oyewole²,

Aderemi³

et al. 2012

GJMS

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Tobacco use is widely spread throughout the world, from countries with low income economics to the most influential industrialized nations. The effect of smoking on human health are serious and in many cases, deadly. This study aimed at estimating the haemorheological parameters and examining the effects of this social behavior on them with a view to educate the smokers and the society. This study was carried out among the regular smokers that smoke not less than two sticks of cigarettes per day. Ninety (90) subjects were studied, comprising of sixty (60)

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“…But, again, the changes were modest, and whether such reductions are associated with reduced disease risk is unknown. Other studies also have shown significant but modest reductions in hematological, fibrinogen, and some indices of lipoprotein biomarkers (Bolliger et al, 2002;Eliasson, Hjalmarson, Kruse, Landfeldt, & Westin, 2001;Haustein, Krause, Haustein, Rasmussen, & Cort, 2004).…”

Section: Methods and Mechanismsmentioning

confidence: 99%

Developing the science base for reducing tobacco harm

Hatsukami

Joseph

LeSage

et al. 2007

CNTR

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The University of Minnesota Transdisciplinary Tobacco Use Research Center has been examining the multiple dimensions and the scientific evidence required to determine the feasibility of tobacco harm reduction as a means to reduce tobacco-related mortality and morbidity. Because of the complexity associated with exploring this area, an interdisciplinary approach is necessary. The research components that have been of particular focus at our center include (a) developing and validating biomarkers of tobacco-related exposure and toxicity, (b) developing animal models and designing studies with humans to assess a variety of smoking reduction approaches and potential reduced exposure products, and (c) determining individual differences in response to these interventions and products. A description of the ongoing activities and challenges in these areas is provided, along with projected directions for the future.

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Changes in hemorheological and biochemical parameters following short-term and long-term smoking cessation induced by nicotine replacement therapy (NRT)

Cited by 35 publications

References 0 publications

Smoking Cessation Program with Exercise Improves Cardiovascular Disease Biomarkers in Sedentary Women

Smoking Cessation Program with Exercise Improves Cardiovascular Disease Biomarkers in Sedentary Women

Evaluation of Haemorheological Parameters in Cigarette Smokers in Western Nigeria

Developing the science base for reducing tobacco harm

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