Changes in hematopoiesis in rats under stress

State of the hematopoietic system in rats subjected to emotional stress after low-dose chronic irradiation

“…The mobilization stage of this syndrome, observed within the first 24 h after the onset of stressful exposure, is characterized by cell depletion of the thymus and spleen (mainly as a result of lymphocyte migration), elevated lymphoid cell counts in the bone marrow, release of mature neutrophils from the marrow into the blood, and neutrophilia, lymphopenia, and eosinopenia in the peripheral blood [2,4,7]. During the first stage, therefore, there occurs massive migration and inter-organ redistribution of various populations of lymphoid cells and of the mature granulocytes.…”

“…During the first stage, therefore, there occurs massive migration and inter-organ redistribution of various populations of lymphoid cells and of the mature granulocytes. This reaction, elaborated in the process of evolution, is a preventive measure against possible infection, and it also constitutes a basis for subse- quent changes in the blood system that lake place during the stage of resistance, whose hallmark is activation of bone marrow hematopoiesis [1][2][3][4].…”