Changes in grey matter volume and functional connectivity in cluster headache versus migraine

Giorgio, Antonio; Lupi, Chiara; Zhang, Jian; Cesaris, Francesco De; Alessandri, Mario; Mortilla, M.; Federico, Antonio; Geppetti, Pierangelo; Stefano, Nicola De; Benemei, Silvia

doi:10.1007/s11682-019-00046-2

Cited by 20 publications

(27 citation statements)

References 40 publications

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“…The studies using the quantitative approach showed different results in episodic CH patients. While some groups did not find any significant differences in diffusion parameters (23,34) in the out-of-bout phase, others reported patterns of stable alterations (i.e., in both in-bout and out-of-bout phase) in the white matter, mainly localized in frontal and limbic lobes (27). Importantly, these regions were shown to present anatomical connections with the hypothalamus when using probabilistic tractography (27).…”

Section: Dtimentioning

confidence: 95%

“…In patients with episodic CH during out-of-bout phase, volumetric alterations of the regions involved in pain processing such as thalamus, caudate nucleus, posterior cingulate cortex, prefrontal cortex, sensorimotor cortex, parietal cortex, insula, and middle temporal cortex have been reported (23,34).…”

Section: Structural Mri Studiesmentioning

confidence: 99%

“…In VBM studies, volumetric gray matter alterations of the visual cortex (cuneus and occipital fusiform gyrus) have been observed (23,34).…”

Section: Structural Mri Studiesmentioning

confidence: 99%

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Understanding Cluster Headache Using Magnetic Resonance Imaging

et al. 2020

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Cluster headache is an excruciating pain syndrome characterized by unilateral head pain attacks, lasting between 15 and 180 min, accompanied by marked ipsilateral cranial autonomic symptoms, such as lacrimation and conjunctival injection. Despite important insights provided by neuroimaging studies and deep brain stimulation findings, the pathophysiology of cluster headache and its pathways of chronicization are still elusive. In this mini-review, we will provide an overview of the functional and structural neuroimaging studies in episodic and chronic cluster headache conditions conducted to clarify the underlying pathophysiology.

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Section: Dtimentioning

confidence: 95%

Section: Structural Mri Studiesmentioning

confidence: 99%

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Understanding Cluster Headache Using Magnetic Resonance Imaging

et al. 2020

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“…Cortical excitability anomalies among migraine patients have been studied through the years with both electrophysiology and functional neuroimaging technologies [1][2][3][4][5][6][7]. Thalamocortical and cortical dysfunctional connectivity seems to be implicated in the pathophysiology of migraine [2][3][4]8] and its clinical counterparts (e.g., pain and cephalic and extracephalic allodynia) [9,10], although these anomalies tend to differ considering the ictal and interictal phases of migraine [11,12].…”

Section: Introductionmentioning

confidence: 99%

Supersaturation of VEP in Migraine without Aura Patients Treated with Topiramate: An Anatomo-Functional Biomarker of the Disease

Luca

Gori

Mazzucchi

et al. 2021

JCM

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Migraine is a primary headache with high prevalence among the general population, characterized by functional hypersensitivity to both exogenous and endogenous stimuli particularly affecting the nociceptive system. The hyperresponsivity of cortical neurons could be due to a disequilibrium in the excitatory/inhibitory signaling. This study aimed to investigate the anatomo-functional pathway from the retina to the primary visual cortex using visual evoked potentials (VEP). Contrast gain protocol was used in 15 patients diagnosed with migraine without aura (at baseline and after 3 months of topiramate therapy) and 13 controls. A saturation (S) index was assessed to monitor the response of VEP’s amplitude to contrast gain. Non-linear nor monotone growth of VEP (S < 0.95) was defined as supersaturation. A greater percentage of migraine patients (53%) relative to controls (7%) showed this characteristic. A strong inverse correlation was found between the S index and the number of days separating the registration of VEP from the next migraine attack. Moreover, allodynia measured through the Allodynia Symptoms Check-list (ASC-12) correlates with the S index both at baseline and after 3 months of topiramate treatment. Other clinical characteristics were not related to supersaturation. Topiramate therapy, although effective, did not influence electrophysiological parameters suggesting a non-intracortical nor retinal origin of the supersaturation (with possible involvement of relay cells from the lateral geniculate nucleus). In conclusion, the elaboration of visual stimuli and visual cortex activity is different in migraine patients compared to controls. More data are necessary to confirm the potential use of the S index as a biomarker for the migraine cycle (association with the pain-phase) and cortical sensitization (allodynia).

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“…frontal, sobre todo en el giro frontal inferior y en el polo frontal, además de en la región postero-lateral de la corteza parietal. Estos cambios reflejan alteración en áreas encargadas de la modulación y regulación del dolor(180). En dicho trabajo se lleva a cabo una valoración de la atrofia total y no de la posible influencia de las diferentes regiones.…”

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La atrofia cerebral como predictor de reperfusión endovascular fútil en el infarto cerebral agudo de circulación anterior

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Changes in grey matter volume and functional connectivity in cluster headache versus migraine

Cited by 20 publications

References 40 publications

Understanding Cluster Headache Using Magnetic Resonance Imaging

Understanding Cluster Headache Using Magnetic Resonance Imaging

Supersaturation of VEP in Migraine without Aura Patients Treated with Topiramate: An Anatomo-Functional Biomarker of the Disease

La atrofia cerebral como predictor de reperfusión endovascular fútil en el infarto cerebral agudo de circulación anterior

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