Changes in Glomerular Capillary Permeability to Dextrans (D) During Development

Abstract

The human kidney excretes u r i c acid(UA) by glomerular f i l t r at i o n , t u b u l a r reabsorption and s e c r e t i o n . Maturational p a t t e r n s of UA t r a n s p o r t i n t h e developing kidney have not been defined. Renal t r a n s p o r t of UA i n t h e mongrel dog i s q u a l i t a t i v e l y s i m i l a r t o the a d u l t human; t h e r e f o r e , CUA, i n u l i n ( C i n ) , plasma volume (PV) and sodium clearance(CNa) were studied i n puppies aged 1-90