Changes in GFR and C<sub>H<sub>H2</sub>O</sub> before and after repair of K deficiency in rats

Holliday, Malcolm A.; Egan, Thomas J.

doi:10.1152/ajplegacy.1962.202.4.773

Cited by 19 publications

(6 citation statements)

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“…However, the values for glomerular filtration rate obtained in the present experi ment closely approximate inulin clearance values in normal rats reported by H olliday and E gan (16).…”

Section: B Pair-jcd Animalssupporting

confidence: 90%

Functional Abnormalities in Experimental Pyelonephritis

Gonick¹,

Goldberg²,

Rubini³

et al. 1965

Nephron

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(1) Concentrating ability was studied in rats with experimental pyelonephritis. Maximal urinary concentration was shown to be reduced as early as one week after introduction of infection and persisted unchanged up to 21 weeks with repetitive injections of bacteria. (2) Glomerular filtration rate was unaltered throughout the study period. PAH clearance fell in the repetitively injected animals. (3) Sodium content of the renal papilla remained normal but urea content fell in the one-week singly injected and 21-week repetitively injected animals. (4) Histological examination showed progressive dilatation of residual collecting ducts. (5) It is suggested that the concentrating defect in early experimental pyelonephritis is due to impaired permeability of the collecting ducts to urea and water.

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“…However, the values for glomerular filtration rate obtained in the present experi ment closely approximate inulin clearance values in normal rats reported by H olliday and E gan (16).…”

Section: B Pair-jcd Animalssupporting

confidence: 90%

Functional Abnormalities in Experimental Pyelonephritis

Gonick¹,

Goldberg²,

Rubini³

et al. 1965

Nephron

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“…The present studies suggest that K depletion may maintain metabolic alkalosis in the rat by diminishing GFR. Reduction in renal blood flow and GFR by selective K depletion is a well described phenomenon in rats (34,35) and dogs (25,26,36). K depletion apparently decreases GFR by selective renal vasoconstriction.…”

Section: Resultsmentioning

confidence: 93%

Metabolic alkalosis in the rat. Evidence that reduced glomerular filtration rather than enhanced tubular bicarbonate reabsorption is responsible for maintaining the alkalotic state.

Cogan¹,

Liu²

1983

J. Clin. Invest.

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A B S T R A C T Maintenance of chronic metabolic alkalosis might occur by a reduction in glomerular filtration rate (GFR) without increased bicarbonate reabsorption or, alternatively, by augmentation of bicarbonate reabsorption with a normal GFR. To differentiate these possibilities, free-flow micropuncture was performed in alkalotic Munich-Wistar rats with a glomerular ultrafiltrate total CO2 concentration of 46.5±0.9 mM (vs. 27.7±0.9 mM in controls). Alkalotic animals had a markedly reduced single nephron GFR compared with controls (27.4±1.5 vs. 51.6±1.6 nl/min) and consequently unchanged filtered load of bicarbonate. Absolute proximal bicarbonate reabsorption in alkalotic animals was similar to controls (981±49 vs. 1,081±57 pmol/min), despite a higher luminal bicarbonate concentration, contracted extracellular volume, and potassium depletion. When single nephron GFR during alkalosis was increased toward normal by isohydric volume expansion or in another group by isotonic bicarbonate loading, absolute proximal bicarbonate reabsorption was not substantially augmented and bicarbonaturia developed. To confirm that a fall in GFR occurs during metabolic alkalosis, additional clearance studies were performed. Awake rats were studied before and after induction of metabolic alkalosis associated with varying amounts of potassium Portions of this work were presented at the National Meet-

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“…In order to provide a control for the effects of renal hypertrophy per se, rats were fed a potassium-deficient diet for 2 wk. Potassium deficiency produces renal hypertrophy but does not increase glomerular filtration or tubular reabsorption of sodium (13 UNINEPHRECTOMY. Glucose-6-phosphatase, Mg' ATPase, and Na-K-ATPase were assayed in the "light microsomal" fraction.…”

Section: Resultsmentioning

confidence: 99%

“…Potassium depletion produces enlargement of the kidney without increasing filtration rate or tubular reabsorption of sodium and water (13). In this form of hypertrophy, Na-K-ATPase remained unchanged, though renal glutaminase increased markedly.…”

Section: Discussionmentioning

confidence: 97%