Changes in gastric mucosal microbiota in gastric carcinogenesis: a systematic review protocol

Ji, Ruoyu; Zhao, Xinyu; Cao, Xinyuan; Zhang, Yizhen; Yang, Yingyun

doi:10.1136/bmjopen-2020-045810

Cited by 2 publications

(4 citation statements)

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“…We will apply funnel plot and Egger’s test to assess publication bias 59. If funnel plots present asymmetry, we will use Egger’s test to statistically examination 63 64…”

Section: Methodsmentioning

confidence: 99%

Gut microbial dysbiosis in rheumatoid arthritis: a systematic review protocol of case-control studies

et al. 2022

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IntroductionRheumatoid arthritis (RA) has a huge societal impact due to the high prevalence, irreversible joint damage and systemic complications. Gut microbiota plays an important role in the pathogenesis and progression of RA by regulating the host immune system. Restoring intestinal homeostasis by altering the microbiota could be an attractive strategy for the prevention and treatment of RA. However, the signature features of microbial dysbiosis in RA are still controversial. Therefore, we aim to elucidate the characteristic change in the diversity and composition of gut microbiota in RA.Methods and analysisWe will systematically search through PubMed, EMBASE, Web of Science and Cochrane Library, as well as dissertations and conference proceedings. The reference lists of all included studies will be also reviewed to retrieve additional relevant studies. The case-control studies that reported either the relative abundance of bacteria at the phylum or genus level or at least one of the alpha-diversity, beta-diversity indexes in both RA and healthy controls will be included. Eligible studies will be screened independently by two reviewers according to the inclusion criteria. The Newcastle-Ottawa Quality Assessment Scale will be used to assess the quality of the included studies. Data extraction, qualitative and quantitative analysis will be performed within the gut microbial dysbiosis in RA. The expected outcomes will be the identification of the specific changes in composition and diversity of the gut microbiota in patients with RA. The quality of evidence will be assessed by the Grading of Recommendations Assessment, Development and Evaluation framework.Ethics and disseminationEthical approval is unnecessary as this review does not address the data and privacy of patients. The results will be published in a peer-reviewed scientific journal and conference presentations.PROSPERO registration numberCRD42021225229.

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“…We will apply funnel plot and Egger’s test to assess publication bias 59. If funnel plots present asymmetry, we will use Egger’s test to statistically examination 63 64…”

Section: Methodsmentioning

confidence: 99%

Gut microbial dysbiosis in rheumatoid arthritis: a systematic review protocol of case-control studies

et al. 2022

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“…We performed the systematic review based on a peer-reviewed and published protocol ( 14 ) with the registration number CRD42020206973 and complied with the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) statement ( 15 ). Reporting items were detailed in the PRISMA checklist ( Supplementary Material ).…”

Section: Methodsmentioning

confidence: 99%

“…in both groups. Detailed inclusion and exclusion criteria were described in the published study protocol ( 14 ). Study selection was conducted by two researchers (YYY and RYJ) independently, with disagreements resolved through discussion.…”

Section: Methodsmentioning

confidence: 99%

“…We assessed the risk of bias using a self-modified Newcastle-Ottawa Scale (NOS) ( 14 ) which was adapted with the intention of best evaluating our phenomenon of interest ( Supplementary Material ). The risk of bias was evaluated from three domains: selection, comparability and exposure (or outcome), and each study was awarded with a maximum of 11 scores.…”

Section: Methodsmentioning

confidence: 99%

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Alterations in Gastric Mucosal Microbiota in Gastric Carcinogenesis: A Systematic Review and Meta-Analysis

Yang

Zhao

et al. 2021

Front. Med.

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Background: The gastric microbiota profile alters during gastric carcinogenesis. We aimed to identify the alterations in the alpha diversity and relative abundance of bacterial phyla and genera of gastric microbiota in the development of gastric cancer (GC).Methods: The systematic review was performed based on a published protocol with the registration number CRD42020206973. We searched through PubMed, EMBASE and Cochrane databases, as well as conference proceedings and references of review articles (May 2021) for observational studies reporting either the relative abundance of bacterial phyla or genera, or alpha diversity indexes in both GC and non-cancer groups. Selection of studies and data extraction were performed independently by two researchers, with disagreements resolved through discussion. Risk of bias was assessed using the self-modified Newcastle-Ottawa Scale. Results of random-effects meta-analyses were presented as mean differences (MD).Results: Our systematic review included 751 GC patients and 792 non-cancer patients from 14 case-control studies. Gastric cancer group had fewer operational taxonomic units (OTUs) (MD = −68.52, 95%CI: −126.65 to −10.39) and a lower Simpson index (MD = −0.13, 95%CI: −0.20 to −0.07) compared with non-cancer group. At the phylum level, gastric cancer group had a higher abundance of Firmicutes (MD = 7.11, 95%CI: 1.76 to 12.46). At the genus level, Streptococcus (MD = 3.03, 95%CI: 0.07 to 6.00) and Lactobacillus (MD = 5.15, 95%CI: 1.27 to 9.04) were found to be enriched in GCgroup. The relative abundance of the rest bacterial phyla or genera analyzed in our study did not significantly differ between two groups. Subgroup analyses indicated that the source of samples was the major source of interstudy heterogeneity.Conclusion: This systematic review suggested that gastric microbiota dysbiosis occurred in gastric carcinogenesis, with alpha diversity declined and microbiota composition altered.

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Changes in gastric mucosal microbiota in gastric carcinogenesis: a systematic review protocol

Cited by 2 publications

References 20 publications

Gut microbial dysbiosis in rheumatoid arthritis: a systematic review protocol of case-control studies

Gut microbial dysbiosis in rheumatoid arthritis: a systematic review protocol of case-control studies

Alterations in Gastric Mucosal Microbiota in Gastric Carcinogenesis: A Systematic Review and Meta-Analysis

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