Changes in gastric acid secretion assayed by endoscopic gastrin test before and after Helicobacter pylori eradication

Abstract

Background-It remains controversial whether or not Helicobacter pylori infection causes altered gastric acid secretion. A novel test for evaluating gastric acid secretion (endoscopic gastrin test; EGT) has recently been developed. Aim-To investigate by EGT the eVects of H pylori eradication on the state of gastric acid secretion in patients with peptic ulcer. Methods-Twenty six patients with duodenal ulcer and 33 with gastric ulcer, for all of whom H pylori infection had been documented, were studied by EGT, histological examination of gastric mucosa, and measurement of plasma gastrin levels before and one and seven months after H pylori eradication. Results-In patients with duodenal ulcer, the mean EGT value before H pylori eradication was higher than that in H pylori negative controls, but it had decreased significantly seven months after the treatment. In contrast, the mean EGT value of patients with gastric ulcer before H pylori eradication was lower than that in H pylori negative controls, but it had increased one month after the treatment; this was followed by a slight decrease at seven months. In both groups, mean EGT values seven months after the treatment were not significantly diVerent from the mean control value. Conclusions-The reduced acid secretion in gastric ulcer patients and gastric acid hypersecretion in duodenal ulcer patients were both normalised after the clearance of H pylori.

Randomised controlled trial of effects of Helicobacter pylori infection and its eradication on heartburn and gastro-oesophageal reflux: Bristol helicobacter project

“…Acid reflux depends more on the integrity of the lower oesophageal sphincter, hence the insignificant effect of H pylori infection on reflux. Patients with severe reflux oesophagitis are less likely to have H pylori infection, [17][18][19][20][21][22][23][24][25][26] possibly because corpus gastritis caused by helicobacter infection limits maximum acid output in these patients, [27][28][29][30][31][32] thus protecting them against the more severe forms of reflux oesophagitis. Such people might theoretically be at risk of increased exposure of the lower oesophagus to acid after eradication of H pylori infection.…”

Cutoff Serum Pepsinogen Values for Predicting Gastric Acid Secretion Status

“…With this method, we measured gastric acid secretion level in a series of patients with various upper GI diseases such as peptic ulcer, reflux esophagitis, Barrett's esophagus, and superficial gastric or esophageal cancer (Iijima et al 1998(Iijima et al , 2000(Iijima et al , 2005(Iijima et al , 2010Koike et al 2001;Abe et al 2004;Inomata et al 2006;Iwai et al 2013). In this study, we retrospectively analyzed the accumulated database based on our previous studies and investigated the correlation between gastric acid secretion levels and serum PG values.…”

Eradication of Helicobacter pylori induces apoptosis and inhibits proliferation of heterotopic proliferative glands in infected Mongolian gerbils

“…A decrease of serum anti-H. pylori IgG titer accompanied eradication, as expected, and acid secretion may have resumed, contributing to the recovery of gastrin level. 18) Our data suggest that changes of cell turnover precede the reduction of HPGs area and therefore are causal for reversibility, upon elimination of the bacteria.…”