Changes in gamma‐aminobutyric acid and glutamate/glutamine levels in the right thalamus of patients with episodic and chronic migraine: A proton magnetic resonance spectroscopy study

Zhang, Xueyan; Wang, Wei; Bai, Xiaoyan; Zhang, Yingkui; Yuan, Ziyu; Tang, Hefei; Zhang, Xue; Li, Zhiye; Zhang, Peng; Hu, Zhangxuan; Zhang, Yaqing; Yu, Xueying; Xue, Ming; Sui, Binbin; Wang, Yonggang

doi:10.1111/head.14449

Cited by 3 publications

(9 citation statements)

References 54 publications

(101 reference statements)

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“…Taken together, the works of Bell et al [ 146 ] and Zhang et al [ 147 ] suggest that there is an association between GABA and the progression of the disorder. In the paediatric sample, there was an association between a higher GABA/Glx ratio and the duration of the disorder, whereas in the adult sample, Zhang et al [ 147 ] suggest that lower GABA concentration is indicative of the chronification of migraine.…”

Section: Differences In Neurotransmittersmentioning

confidence: 79%

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Excitation-Inhibition Imbalance in Migraine: From Neurotransmitters to Brain Oscillations

O’Hare

Tarasi

Asher

et al. 2023

IJMS

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Migraine is among the most common and debilitating neurological disorders typically affecting people of working age. It is characterised by a unilateral, pulsating headache often associated with severe pain. Despite the intensive research, there is still little understanding of the pathophysiology of migraine. At the electrophysiological level, altered oscillatory parameters have been reported within the alpha and gamma bands. At the molecular level, altered glutamate and GABA concentrations have been reported. However, there has been little cross-talk between these lines of research. Thus, the relationship between oscillatory activity and neurotransmitter concentrations remains to be empirically traced. Importantly, how these indices link back to altered sensory processing has to be clearly established as yet. Accordingly, pharmacologic treatments have been mostly symptom-based, and yet sometimes proving ineffective in resolving pain or related issues. This review provides an integrative theoretical framework of excitation–inhibition imbalance for the understanding of current evidence and to address outstanding questions concerning the pathophysiology of migraine. We propose the use of computational modelling for the rigorous formulation of testable hypotheses on mechanisms of homeostatic imbalance and for the development of mechanism-based pharmacological treatments and neurostimulation interventions.

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Section: Differences In Neurotransmittersmentioning

confidence: 79%

“…In adults, Zhang et al [ 147 ] measured GABA and Glx levels in the thalamus in chronic and episodic migraine (MO). They found lower GABA concentration in chronic migraine, but lower Glx concentration in episodic migraine compared to control groups.…”

Section: Differences In Neurotransmittersmentioning

confidence: 99%

Excitation-Inhibition Imbalance in Migraine: From Neurotransmitters to Brain Oscillations

O’Hare

Tarasi

Asher

et al. 2023

IJMS

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“…The CeA receives inputs from spinal and trigeminal nociceptive neurons; it projects to various brain regions involved in pain perception, such as the hypothalamus, periaqueductal gray, and nucleus raphe [ 39 – 41 ]. Moreover, there is evidence that neurons in the amygdala regulate pain conduction by releasing glutamate and gamma-aminobutyric acid (GABA) neurotransmitters; these neurotransmitters may affect migraine onset [ 42 – 44 ]. Increased cerebral perfusion in the bilateral amygdala may be associated with neurotransmitter hyperactivation in the amygdala, which leads to increased neurotransmitter release from neurons in the amygdala and promotes migraine persistence [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

Hyperperfusion of bilateral amygdala in patients with chronic migraine: an arterial spin-labeled magnetic resonance imaging study

Bai,

Wang,

Zhang

et al. 2023

J Headache Pain

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Background Amygdala, an essential element of the limbic system, has served as an important structure in pain modulation. There is still a lack of clarity about altered cerebral perfusion of amygdala in migraine. This study aimed to investigate the perfusion variances of bilateral amygdala in episodic migraine (EM) and chronic migraine (CM) using multi-delay pseudo-continuous arterial spin-labeled magnetic resonance imaging (pCASL-MRI). Methods Twenty-six patients with EM, 55 patients with CM (33 CM with medication overuse headache (MOH)), and 26 age- and sex-matched healthy controls (HCs) were included. All participants underwent 3D multi-delay pCASL MR imaging to obtain cerebral perfusion data, including arrival-time-corrected cerebral blood flow (CBF) and arterial cerebral blood volume (aCBV). The CBF and aCBV values in the bilateral amygdala were compared among the three groups. Correlation analyses between cerebral perfusion parameters and clinical variables were performed. Results Compared with HC participants, patients with CM were found to have increased CBF and aCBV values in the left amygdala, as well as increased CBF values in the right amygdala (all P < 0.05). There were no significant differences of CBF and aCBV values in the bilateral amygdala between the HC and EM groups, the EM and CM groups, as well as the CM without and with MOH groups (all P > 0.05). In patients with CM, the increased perfusion parameters of bilateral amygdala were positively correlated with MIDAS score after adjustments for age, sex, and body mass index (BMI). Conclusion Hyperperfusion of bilateral amygdala might provide potential hemodynamics evidence in the neurolimbic pain network of CM.

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“…This substudy is one of multiple planned analyses. The data and all results involved in this study were first analyzed and reported, except data regarding the age, sex, and body mass index of 16 HCs, which were described in the previous reports 21,22 …”

Section: Methodsmentioning

confidence: 99%

“…Severe (20)(21)(22)(23)(24)(25)(26)(27), n (%) 2 (9.1%) Depression (PHQ-9 score ≥ 10), n (%) 10 (45.5%)…”

Section: Questionnaires and Scales Ndph (N = 22)mentioning

confidence: 99%

Normal glymphatic system function in patients with new daily persistent headache using diffusion tensor image analysis along the perivascular space

et al. 2023

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Objectives To investigate the glymphatic function in patients with new daily persistent headache (NDPH) using the diffusion tensor image analysis along the perivascular space (DTI‐ALPS) method. Background NDPH, a rare and treatment‐refractory primary headache disorder, is poorly understood. There is limited evidence to suggest that headaches are associated with glymphatic dysfunction. Thus far, no studies have evaluated glymphatic function in patients with NDPH. Methods In this cross‐sectional study conducted in the Headache Center of Beijing Tiantan Hospital, patients with NDPH and healthy controls were enrolled. All participants underwent brain magnetic resonance imaging examinations. Clinical characteristics and neuropsychological evaluation were examined in patients with NDPH. ALPS indexes for both hemispheres were measured to determine the glymphatic system function in patients with NDPH and healthy controls. Results In total, 27 patients with NDPH (14 males, 13 females; age [mean ± standard deviation (SD)]: 36.6 ± 20.6) and 33 healthy controls (15 males, 18 females; age [mean ± SD]: 36.0 ± 10.8) were included in the analysis. No significant differences between groups were observed in the left ALPS index (1.583 ± 0.182 vs. 1.586 ± 0.175, mean difference = 0.003, 95% confidence interval [CI] of difference = −0.089 to 0.096, p = 0.942), or right ALPS index (1.578 ± 0.230 vs. 1.559 ± 0.206, mean difference = −0.027, 95% CI of difference = −0.132 to 0.094, p = 0.738). Additionally, ALPS indexes were not correlated with clinical characteristics or neuropsychiatric scores. Conclusion No glymphatic dysfunction was detected in patients with NDPH by means of the ALPS method. Additional studies with larger samples are needed to confirm these preliminary findings and improve the understanding of glymphatic function in NDPH.

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Changes in gamma‐aminobutyric acid and glutamate/glutamine levels in the right thalamus of patients with episodic and chronic migraine: A proton magnetic resonance spectroscopy study

Cited by 3 publications

References 54 publications

Excitation-Inhibition Imbalance in Migraine: From Neurotransmitters to Brain Oscillations

Excitation-Inhibition Imbalance in Migraine: From Neurotransmitters to Brain Oscillations

Hyperperfusion of bilateral amygdala in patients with chronic migraine: an arterial spin-labeled magnetic resonance imaging study

Normal glymphatic system function in patients with new daily persistent headache using diffusion tensor image analysis along the perivascular space

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