Changes in Foxp3-Positive Regulatory T Cell Number in the Intestine of Dogs With Idiopathic Inflammatory Bowel Disease and Intestinal Lymphoma

Maeda, Shingo; Ohno, Koichi; Fujiwara‐Igarashi, Aki; Uchida, Kazuyuki; Tsujimoto, Hajime

doi:10.1177/0300985815591081

Cited by 48 publications

(57 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies describing the disease entity have focused on pathologic, immunohistochemical, and molecular characteristics and did not include information describing clinical features(6,7,22). Based on results presented here, dogs with small cell intestinal lymphoma appear to have a favorable outcome when undergoing any type of therapy, with an MST of 628 days.…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics and outcome in dogs with small cell T‐cell intestinal lymphoma

Couto

Moore

Zwingenberger

et al. 2018

Vet Comparative Oncology

View full text Add to dashboard Cite

Small cell intestinal lymphoma has not been well characterized in dogs. The objective of this study was to describe clinical characteristics and outcome in dogs with small cell intestinal lymphoma. We hypothesized that affected dogs would have prolonged survival compared to high-grade GI lymphoma. Pathology records were searched for dogs with histologically confirmed small cell GI lymphoma. Seventeen dogs with confirmed small cell intestinal lymphoma were identified, and clinical and outcome data were retrospectively collected. Histopathology was reviewed by a board-certified pathologist, and tissue sections were subjected to immunophenotyping and molecular clonality assessment. All dogs had small cell, T-cell, lymphoma confirmed within various regions of small intestine, with 1 dog also having disease in abdominal lymph nodes. All dogs had clinical signs attributable to GI disease; diarrhea (n=13) was most common. Ultrasonographic abnormalities were present in 8 of 13 dogs with abnormal wall layering (n=7) and hyperechoic mucosal striations (n=7) representing the most common findings. In total, 14 dogs received some form of treatment. The median survival time (MST) for all dogs was 279 days and the MST for the 14 dogs that received any treatment was 628 days. Dogs with anemia and weight loss at presentation had significantly shorter survival times and dogs that received a combination of steroids and an alkylating agent had significantly longer survival times. Small cell, T-cell, intestinal lymphoma is a distinct disease process in dogs, and those undergoing treatment may experience prolonged survival.

show abstract

Section: Discussionmentioning

confidence: 99%

Clinical characteristics and outcome in dogs with small cell T‐cell intestinal lymphoma

Couto

Moore

Zwingenberger

et al. 2018

Vet Comparative Oncology

View full text Add to dashboard Cite

show abstract

“…Regulatory T cells (T reg ) play an important role in cell‐mediated mucosal immunotolerance and were decreased in duodenal biopsy specimens from dogs with CIE 168, 169. Numbers of circulating T reg were also decreased in peripheral blood samples from dogs with CIE (IRE and PLE), and this cellular biomarker might be useful to monitor disease progression (ie, disease activity) and assess response to treatment 170.…”

Section: Biomarkers In Chronic Inflammatory Enteropathies Of Dogsmentioning

confidence: 99%

Clinical utility of currently available biomarkers in inflammatory enteropathies of dogs

Heilmann

Steiner

2018

Veterinary Internal Medicne

108

View full text Add to dashboard Cite

Chronic inflammatory enteropathies (CIE) in dogs are a group of disorders that are characterized by chronic persistent or recurrent signs of gastrointestinal disease and histologic evidence of mucosal inflammation. These CIEs are classified as either food‐responsive, antibiotic‐responsive, or immunosuppressant‐responsive enteropathy. Patients not clinically responding to immunomodulatory treatment are grouped as nonresponsive enteropathy and dogs with intestinal protein loss as protein‐losing enteropathy. Disease‐independent clinical scoring systems were established in dogs for assessment of clinical disease severity and patient monitoring during treatment. Histopathologic and routine clinicopathologic findings are usually not able to distinguish the subgroups of CIE. Treatment trials are often lengthy and further diagnostic tests are usually at least minimally invasive. Biomarkers that can aid in defining the presence of disease, site of origin, severity of the disease process, response to treatment, or a combination of these would be clinically useful in dogs with CIE. This article summarizes the following biomarkers that have been evaluated in dogs with CIE during the last decade, and critically evaluates their potential clinical utility in dogs with CIE: functional biomarkers (cobalamin, methylmalonic acid, folate, α1‐proteinase inhibitor, immunoglobulin A), biochemical biomarkers (C‐reactive protein, perinuclear anti‐neutrophilic cytoplasmic antibodies, 3‐bromotyrosine, N‐methylhistamine, calprotectin, S100A12, soluble receptor of advanced glycation end products, cytokines and chemokines, alkaline phosphatase), microbiomic biomarkers (microbiome changes, dysbiosis index), metabolomic biomarkers (serum metabolome), genetic biomarkers (genomic markers, gene expression changes), and cellular biomarkers (regulatory T cells). In addition, important performance criteria of diagnostic tests are briefly reviewed.

show abstract

“…Abnormalities in Treg number or function may contribute to the pathogenesis of CCUS as it does in canine inflammatory bowel disease. 26,35 CD4þ Th17 cells play an important role in host defense against extracellular pathogens by mediating the recruitment of neutrophils and macrophages to infected tissues. 53 Interleukin-17 (IL-17) is a proinflammatory cytokine derived mainly from activated CD4þ Th17 cells and also from innate lymphoid cells, CD8þ T cells, neutrophils, monocytes, macrophages, mast cells, and vascular smooth muscle cells.…”

mentioning

confidence: 99%

Clinical and Histopathologic Characterization of Canine Chronic Ulcerative Stomatitis

et al. 2017

View full text Add to dashboard Cite

Canine chronic ulcerative stomatitis, also known as chronic ulcerative paradental stomatitis, is a painful condition of the oral cavity. The purpose of this study was to determine if there are commonalities in clinical and radiographic features among patients, whether the histopathologic evaluation might inform the pathogenesis, and whether the condition appears similar to human oral mucosal diseases. To do this, we prospectively collected clinical, radiographic, and histopathologic data from 20 dogs diagnosed with the disease. Clinical data were based on a clinical disease activity index, oral and periodontal examination parameters, and full-mouth dental radiographs. The histopathological and immunohistochemical data were based on oral mucosal samples obtained from erosive or ulcerated areas. Our findings revealed that canine chronic stomatitis is clinically characterized by painful oral mucosal ulcers of varying size, pattern, appearance, and distribution, most often associated with teeth with early periodontitis. Histologic examination revealed a subepithelial lichenoid band (interface mucositis) where B cells, T cells, and Forkheadbox protein 3 (FoxP3)-and interleukin-17-expressing cells were present. These cells might play a role in the underlying immune response and an immune-mediated pathogenesis is suspected. The clinical and histopathologic features of this chronic inflammatory mucosal disease in dogs resemble those of oral lichen planus in humans.

show abstract

Changes in Foxp3-Positive Regulatory T Cell Number in the Intestine of Dogs With Idiopathic Inflammatory Bowel Disease and Intestinal Lymphoma

Cited by 48 publications

References 64 publications

Clinical characteristics and outcome in dogs with small cell T‐cell intestinal lymphoma

Clinical characteristics and outcome in dogs with small cell T‐cell intestinal lymphoma

Clinical utility of currently available biomarkers in inflammatory enteropathies of dogs

Clinical and Histopathologic Characterization of Canine Chronic Ulcerative Stomatitis

Contact Info

Product

Resources

About