Changes in FKBP5 expression and memory functions during cognitive–behavioral therapy in posttraumatic stress disorder: A preliminary study

Szabó, Csilla; Kelemen, Ogúz; Kéri, Szabolcs

doi:10.1016/j.neulet.2014.03.059

Cited by 27 publications

(16 citation statements)

References 30 publications

(41 reference statements)

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“…This is consistent with our previous reports that low CB2R function induces depression-like symptoms in the mouse model and alcohol addiction in human population [ 3 ]. FKBP5/Fkbp5 is one of the biomarkers for posttraumatic stress disorder (PTSD): The FKBP5 gene expression was reported to be low but elevated during cognitive behavioral therapy (CBT) in PTSD patients [ 37 , 38 ]. Consistent with the PTSD study, the results from our experiments using a mouse model demonstrated a reduction of the Fkbp5 gene expression after CMS.…”

Section: Discussionmentioning

confidence: 99%

Cannabinoid CB2 Receptor Gene and Environmental Interaction in the Development of Psychiatric Disorders

et al. 2018

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CB2 cannabinoid receptor (CB2R) gene is associated with depression. We investigated the gene-environment interaction between CB2R function and diverse stressors. First, anxiety-like behavior during chronic-mild-stress (CMS) was evaluated in C57BL/6JJmsSlc mice following treatment with CB2R agonist JWH015 or inverse-agonist AM630. Second, locomotor activity and anxiety-like behavior were measured following exposure to an immune poly I:C stressor. Gene expressions of HPA axis related molecules, Fkbp5, Nr3c1 and Crf and pro-inflammatory cytokine Il-1b, as well as Bdnf as a key neurotrophin that supports neuron health, function, and synaptic plasticity, were determined in hippocampus of Cnr2 knockout mice, as indicators of stressful environment. CMS-induced anxiety-like behavior was enhanced by AM630 and reduced by JWH015 and fluvoxamine. Poly I:C reduced locomotor activity and increased anxiety-like behavior, and these effects were pronounced in the heterozygote than in the wild type mice. Fkbp5 and Nr3c1 expression were lower in the Cnr2 heterozygotes than in the wild type mice with Poly I:C treatment. These findings indicate that interaction between CB2R gene and stressors increases the risk of depression-like behaviors that may be linked with neuro-immune crosstalk. Further studies in human subjects are necessary to determine the role of CB2R and environmental interaction in the development of depression.

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Section: Discussionmentioning

confidence: 99%

Cannabinoid CB2 Receptor Gene and Environmental Interaction in the Development of Psychiatric Disorders

et al. 2018

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“…Two previous small studies have applied a similar approach to identify epigenetic changes associated with cognitive behavioral therapy and found increases in blood FKBP5 mRNA expression following therapy. 62,63 FK506-binding protein was included in the set of target genes for our study, but no significant change in expression level was detected. Future studies might examine whether there are distinct epigenetic pathways shared by both EFT and cognitive behavioral therapy.…”

Section: Discussionmentioning

confidence: 99%

Epigenetic Effects of PTSD Remediation in Veterans Using Clinical Emotional Freedom Techniques: A Randomized Controlled Pilot Study

Church¹,

Yount

Rachlin

et al. 2016

Am J Health Promot

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“…Recently, a genetic variant in the PAC1 receptor (ADCYAP1R1; rs2267735) was found to be associated with PTSD [54,55]. Of particular interest were the findings that a genetic variation of the glucocorticoid receptor cochaperone protein, FKBP5, moderates risk of developing PTSD in childhood abuse cases [56][57][58][59][60][61]. Binder and colleagues found that 4 SNPs in FKBP5 (rs9296158, rs3800373, 1360780, rs9470080) interacted with child abuse severity to predict adult PTSD symptoms [62].…”

Section: Hpa Axis Candidate Genesmentioning

confidence: 99%

Genetics of Posttraumatic Stress Disorder — Candidate Genes and Their Implication in the Disease-Associated Molecular Pathomechanisms

Anna¹,

Avetyan²,

Hovhannisyan³

et al. 2015

A Fresh Look at Anxiety Disorders

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Posttraumatic stress disorder PTSD is a complex psychiatric disorder DSM-V code .ICD-codes F . . PTSD is an anxiety disorder developed in a person experiencing, witnessing, or learning about an extreme physically or/and psychologically distressing event. Its incidence and the number of this disease-affected people are threateningly increasing in contemporary society. Therefore, the development of prognostic strategies and novel efficient methods on early diagnostics and treatment of PTSD is currently considered as one of the most important healthcare problems worldwide.Results of epidemiologic, clinical, and experimental studies suggest implication of both environmental and genetic factors in pathomechanisms of PTSD and that, most probably, PTSD belongs to complex disorders with polygenic inheritance. Whereas the environmental factors triggering PTSD are well defined, less is known about PTSD-associated genetic variations and molecular etiopathomechanisms.Several studies, including our own reports, suggest the involvement of neuro-immune alterations in the pathophysiology of PTSD. These include changes in neuronal plasticity, synaptic connectivity, humoral and cellular immune-mediated responses, and apoptosis rate leading to cognitive deficit and behavioral changes in patients with PTSD accompanied with development of low-grade inflammatory reactions.Currently, many research groups working on elucidation of molecular mechanisms of PTSD are exploring whether these changes have genetic background or are induced by other external or internal environmental factors. In the present chapter, we provide overview and discussion of the existing data, including our own results, on variations in genes encoding neuro-immune and apoptotic mediators and regulators and related transcription factors in PTSD patients.Potential role of these genetic variations in generation and development of PTSD is considered and the implication of relevant candidate genes in mechanisms responsible for disease progression is proposed.

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Changes in FKBP5 expression and memory functions during cognitive–behavioral therapy in posttraumatic stress disorder: A preliminary study

Cited by 27 publications

References 30 publications

Cannabinoid CB2 Receptor Gene and Environmental Interaction in the Development of Psychiatric Disorders

Cannabinoid CB2 Receptor Gene and Environmental Interaction in the Development of Psychiatric Disorders

Epigenetic Effects of PTSD Remediation in Veterans Using Clinical Emotional Freedom Techniques: A Randomized Controlled Pilot Study

Genetics of Posttraumatic Stress Disorder — Candidate Genes and Their Implication in the Disease-Associated Molecular Pathomechanisms

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