Changes in Fetal and Maternal Blood Levels of Prolactin, Cortisol, and Cortisone during Eutocic and Dystocic Childbirth

Cauwenberge, J. R. Van; Hustin, J.; Demey-Ponsart, E.; Sulon, Joseph; Reuter, A.; Lambotte, R; Franchimont, P

doi:10.1159/000180643

Cited by 13 publications

(7 citation statements)

References 15 publications

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“…We have previously demonstrated that this Cort exposure increases maternal plasma Cort concentrations by approximately threefold compared to Untr levels 4 . We have recently demonstrated a similar magnitude of change in Cort concentrations in rats that were subjected to acute restraint stress 21 and previous studies have demonstrated a similar relative increase in women with a stressful labour 22 . Using this physiologically relevant model of Cort exposure, our results lead us to conclude that changes in OGT and hexosamine signalling in the placenta in response to maternal stress is likely to be a key mechanism through which sex-specific fetal programming occurs.…”

Section: Introductionsupporting

confidence: 72%

Placental O-GlcNAc-transferase expression and interactions with the glucocorticoid receptor are sex specific and regulated by maternal corticosterone exposure in mice

Pantaleon

Steane

McMahon

et al. 2017

Sci Rep

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Maternal stress programs offspring disease in a sexually dimorphic manner with males often more adversely affected. Previous studies of maternal glucocorticoid exposure suggest male vulnerability may derive from placental alterations. The hexosamine signalling pathway and O-linked glycosylation (O-GlcNAcylation) are part of an essential adaptive survival response in healthy cells. The key enzyme involved is O-linked-N-acetylglucosamine transferase (OGT), a gene recently identified as a sex-specific placental biomarker of maternal stress. Using a mouse model of maternal corticosterone (Cort) exposure, we examined components of hexosamine biosynthesis/signalling and O-GlcNAcylation in whole placentae at E14.5. Our results demonstrate sex-specific differences in OGT levels and O-GlcNAcylation during Cort exposure which impacts on key mediators of cell survival, in particular AKT as well as the stress responsive OGT/GR transrepression complex. In male placentae only, Cort exposure increased Akt O-GlcNacylation which correlated with decreased phosphorylation. Female placentae had higher basal OGT and OGT/GR complex compared with male placentae. Cort exposure did not alter these levels in female placentae but increased global O-GlcNacylation. In male placentae Cort increased OGT and OGT/GR complex with no change in global O-GlcNacylation. These findings suggest that sex-specific differences in placental OGT play a key role in the sexually dimorphic responses to stress.

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Section: Introductionsupporting

confidence: 72%

Placental O-GlcNAc-transferase expression and interactions with the glucocorticoid receptor are sex specific and regulated by maternal corticosterone exposure in mice

Pantaleon

Steane

McMahon

et al. 2017

Sci Rep

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“…More over, the breast-feeding procedure does not affect the dayby-day postpartum decline in cortisol levels, which were physiologically increased during late pregnancy [13] and delivery [14][15][16].…”

Section: Discussionmentioning

confidence: 91%

Maternal Plasma and Milk Free Cortisol during the First 3 Days of Breast-Feeding following Spontaneous Delivery or Elective Cesarean Section

Patacchioli

Cigliana

Cilumbriello

et al. 1992

Gynecol Obstet Invest

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In a view of the increased clinical interest in the presence of hormones in human milk, the objective of this study was to evaluate maternal plasma and milk cortisol levels in early puerperium and their relationship in breast-feeding in women who underwent elective cesarean section or who delivered vaginally. During the first 3 days of breast-feeding, plasma and milk cortisol levels declined significantly both in women who underwent elective cesarean section and in women who had spontaneous deliveries. Moreover, the breast-feeding procedure did not affect maternal plasma and milk hormonal levels, since no differences between the cortisol levels measured immediately before and after morning daily breast-feeding were detected. Furthermore, a very high positive correlation (p < 0.001) was found between plasma and milk cortisol concentrations. Therefore, maternal plasma cortisol levels can be considered a very reliable measure to predict the hormonal concentration in breast milk.

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“…It is thought that the PRL concentrations are increased in stress [8,17], Also, increased PRL concentrations have been found in dystocic childbirths [6]. In addition, GH is often increased in fetal 'stress' conditions, such as in fetuses of undernourished ewes [18], in ovine fetuses undergoing surgery [8], and in hypoxaemic or acidotic ovine fetuses [8].…”

Section: Prl and Hgh In Perinatal Asphyxiamentioning

confidence: 99%

Prolactin and Growth Hormone in Perinatal Asphyxia

Varvarigou¹,

Vagenakis

Makri

et al. 1996

Neonatology

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To assess the pituitary response to perinatal asphyxia, the prolactin (PRL) and growth hormone (hGH) serum concentrations were measured in 55 asphyctic (15 preterm and 40 full-term) and 35 control (15 preterm and 20 full-term) newborns at 2-4,24,48 and 96 h of life. At 2-4 h the median PRL in the preterm asphyctic neonates was 5.2 U/l, whereas in the preterm control newborns it was 3.2. In the full-term newborns with and without hypoxic-ischaemic encephalopathy (HIE) it was 5.8 and 3.4, respectively. In the full-term neonates with HIE the PRL remained significantly higher than in the controls up to the fourth day. At 2–4 h the median hGH in the preterm asphyctic and control newborns was 106.2 and 54.8 mU/l, respectively. In the full-term newborns it was 85.0 and 40.8, respectively. The lowest hGH concentrations were found in the severe HIE. The increased PRL and hGH in asphyxia may result from a stress-related hormone release, whereas the very low hGH concentrations in severe HIE may result from a damage at the hypothalamic-hypophyseal axis.

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Changes in Fetal and Maternal Blood Levels of Prolactin, Cortisol, and Cortisone during Eutocic and Dystocic Childbirth

Cited by 13 publications

References 15 publications

Placental O-GlcNAc-transferase expression and interactions with the glucocorticoid receptor are sex specific and regulated by maternal corticosterone exposure in mice

Placental O-GlcNAc-transferase expression and interactions with the glucocorticoid receptor are sex specific and regulated by maternal corticosterone exposure in mice

Maternal Plasma and Milk Free Cortisol during the First 3 Days of Breast-Feeding following Spontaneous Delivery or Elective Cesarean Section

Prolactin and Growth Hormone in Perinatal Asphyxia

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