Changes in fatigue, barriers, and predictors towards physical activity in advanced cancer patients over a period of 12 months—a comparative study

Frikkel, J.; Beckmann, Mingo; Lazzari, Nico De; Götte, Miriam; Kasper, Stefan; Hense, J.; Schüler, Martin; Teufel, Martin; Tewes, Mitra

doi:10.1007/s00520-021-06020-3

Cited by 3 publications

(1 citation statement)

References 49 publications

(68 reference statements)

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“…16 30 31 33 34 37 40 The debilitating impact of fatigue can extend beyond physical functioning and impair a patient's capacity for self-care and their ability to work or participate in activities that previously provided joy and comfort. [71][72][73] Such factors should be taken into account by clinicians when considering a patient's suitability for checkpoint inhibitors and supportive care interventions need to be routinely available to help the patient cope with fatigue and preserve QoL.…”

Section: Discussionmentioning

confidence: 99%

Experience of patients considering or using checkpoint inhibitors in cancer treatment: a systematic review of qualitative research

Yip,

Arnolda,

Lamprell

et al. 2024

J Immunother Cancer

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Increasing numbers of patients with cancer are considering or undergoing immunotherapy, however, little is known about patients’ perspectives on this treatment. We undertook a systematic review for use by clinicians and researchers, consolidating published qualitative research studies on patient experience of checkpoint inhibitor therapy. A search of Medline, Embase, and PsycINFO was carried out for publications in English to 30 June 2022. Publications were selected if they reported a qualitative study of patient experience with checkpoint inhibitor therapy for cancer, either by patients or their families or carers. Quality was appraised using the Johanna Briggs Institute quality assessment tool for qualitative studies. A thematic synthesis was conducted. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses standard was followed. We identified 17 eligible studies published between 2017 and 2022, 9 using mixed methods, and 8 solely using qualitative methods. Most studies reported on the experiences of patients with advanced stage melanoma and were using the earliest approved checkpoint inhibitors for cancer therapy. Studies met most formal quality criteria but varied in the extent of their qualitative explorations of data; some mixed methods studies had limited reporting of qualitative results. Through thematic synthesis, we categorized study findings into four domains: (1) treatment decision-making; (2) success with immunotherapy; (3) treatment-related adverse events (AEs); and (4) quality of life on immunotherapy. Our review identified several areas with potential for improving the care system. These include, for example: routinely linking patients to peers who have experienced this therapy; improving the capacity of patients and carers to identify and report AEs faster; and supporting patients and carers to live with changed circumstances after successful treatment. Most studies focused on patients who had successful treatment, effectively excluding those who do not respond or who discontinue due to serious side effects; future research targets are suggested.

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Section: Discussionmentioning

confidence: 99%

Experience of patients considering or using checkpoint inhibitors in cancer treatment: a systematic review of qualitative research

Yip,

Arnolda,

Lamprell

et al. 2024

J Immunother Cancer

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Physical exercise habits, lifestyle behaviors, and motivation to change among men with prostate cancer: a cross-sectional study

Bressi

Iotti

Cagliari

et al. 2022

Support Care Cancer

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Management of Fatigue in Patients with Advanced Cancer

Stone

Candelmi

Kandola

et al. 2023

Curr. Treat. Options in Oncol.

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Opinion statementFatigue is a common and distressing symptom experienced by patients with cancer. It is most common in patients with locally advanced or metastatic incurable disease. It can have profound effects on quality-of-life and physical functioning. In addition to general supportive measures (directed at tackling contributory conditions and comorbidities), a variety of specific interventions have been developed which can be broadly categorised as physical therapies, psychological therapies or medication. There is some evidence that each of these approaches can have benefits in patients with earlier stage disease, those undergoing active treatment and in cancer survivors. The best evidence is for aerobic exercise, yoga, cognitive-behavioural therapy (CBT) and psycho-educational interventions. Less strong evidence supports the use of medications such as methylphenidate or ginseng. In patients with advanced disease, it is likely that the mechanisms of fatigue or the factors contributing to fatigue maintenance may be different. Relatively fewer studies have been undertaken in this group and the evidence is correspondingly weaker. The authors recommend the cautious use of aerobic exercise (e.g. walking) in those who are still mobile. The authors advise considering the use of psycho-educational approaches or CBT in those patients who are able to engage in such forms of therapy. In patients near the end-of-life, the authors advise use of dexamethasone (short-term use) and other pharmacological treatments only on the basis of a clinical trial.

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Changes in fatigue, barriers, and predictors towards physical activity in advanced cancer patients over a period of 12 months—a comparative study

Cited by 3 publications

References 49 publications

Experience of patients considering or using checkpoint inhibitors in cancer treatment: a systematic review of qualitative research

Experience of patients considering or using checkpoint inhibitors in cancer treatment: a systematic review of qualitative research

Physical exercise habits, lifestyle behaviors, and motivation to change among men with prostate cancer: a cross-sectional study

Management of Fatigue in Patients with Advanced Cancer

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