Changes in fatigability following intense aerobic exercise training in patients with interstitial lung disease

Keyser, Randall E.; Christensen, E.; Chin, Lisa M.K.; Woolstenhulme, Joshua G.; Drinkard, Bart; Quinn, Anne; Connors, Gerilynn; Weir, Nargues; Nathan, Steven D.; Chan, Leighton

doi:10.1016/j.rmed.2015.01.021

Cited by 20 publications

(21 citation statements)

References 41 publications

(55 reference statements)

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“…40 A gradual decline in the 6MWT is associated with increased mortality in ILD patients, especially those with IPF. 41 A meta-analysis of studies performed on small groups of patients (43 in total who underwent PR and 42 controls) showed that the patients with IPF demonstrated less improvement after PR than the patients with other ILDs. In the IPF group, an average increase in the 6MWT immediately after PR was 26.55 m; in the remaining patients with ILDs, it was 38.61 m. This may be related to the initial severity and faster course of the disease in IPF patients.…”

Section: General Rules Of Qualification For Pulmonary Rehabilitation mentioning

confidence: 99%

“…In the IPF group, an average increase in the 6MWT immediately after PR was 26.55 m; in the remaining patients with ILDs, it was 38.61 m. This may be related to the initial severity and faster course of the disease in IPF patients. 41 In a study conducted on a group of 32 patients with IPF, 15 were subjected to a 12-week exercise-based PR program and showed significant improvement in exercise tolerance, functional capacity and FVC. To evaluate exercise tolerance, the cardiopulmonary exercise test was used; after 12 weeks of PR, there was a significant increase in VO 2 max.…”

Section: General Rules Of Qualification For Pulmonary Rehabilitation mentioning

confidence: 99%

See 1 more Smart Citation

Pulmonary rehabilitation in interstitial lung diseases: A review of the literature

Wytrychowski¹,

Hans-Wytrychowska²,

Piesiak³

et al. 2020

Adv Clin Exp Med

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There are more than 200 different diseases classed as interstitial lung diseases (ILDs). For epidemiological and practical purposes, ILDs are classified into diseases of known and unknown etiology. The aim of this review is to evaluate our current knowledge about the efficacy and safety of pulmonary rehabilitation (PR) in patients with ILDs. Other issues, such as ILD pathogenesis, prevalence and comorbidity, are also elaborated in the review. Pulmonary rehabilitation is an important part of comprehensive care for patients with ILDs. In comparison to PR for patients with chronic pulmonary obstructive disease (COPD), the number of clinical studies concerning PR for patients with ILDs is small. The majority of trials have been performed in relatively small groups of patients. The principles of PR in this group of patients are the same as for patients with COPD. Exercise-induced desaturation is frequently observed during PR, which is the main source of complications in patients with ILDs. Major differences between ILD and COPD patients include poorer exercise tolerance and faster development of respiratory failure in patients with ILDs.

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Section: General Rules Of Qualification For Pulmonary Rehabilitation mentioning

confidence: 99%

Section: General Rules Of Qualification For Pulmonary Rehabilitation mentioning

confidence: 99%

Pulmonary rehabilitation in interstitial lung diseases: A review of the literature

Wytrychowski¹,

Hans-Wytrychowska²,

Piesiak³

et al. 2020

Adv Clin Exp Med

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show abstract

“…Exercise training improves subjective fatigue in people with ILD [Holland et al 2008] and sarcoidosis [Strookappe et al 2015]. A recent study affirmed improvement in objective muscle fatigability using intense aerobic-exercise training in patients with ILD [Keyser et al 2015].…”

Section: Nonexercise Trainingmentioning

confidence: 99%

Current best practice in rehabilitation in interstitial lung disease

Nakazawa

Cox

Holland

2016

Ther Adv Respir Dis

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Abstract:Interstitial lung disease (ILD) is a group of chronic respiratory diseases characterized by dyspnoea on exertion and decline in health-related quality of life (HRQL). People with ILD experience significant exercise limitation with contributors that include ventilatory limitation, impaired gas exchange, decreased cardiac function and skeletal muscle dysfunction. Pulmonary rehabilitation (PR) is well established in patients with chronic obstructive pulmonary disease (COPD) as a means to overcome exercise limitation and improve activity-related dyspnoea. There is increasing evidence for similar effects of PR in people with ILD. This review discusses the evidence for PR in ILD, outlines the essential components of PR in this population, and highlights special considerations for exercise training in people with ILD. Possible future directions for PR research in people with ILD are explored.

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“…Fatigue is one of the most common symptoms in patients with respiratory disorders [ 35 ]. Keyser et al showed that aerobic exercise reduces the rate of fatigue in interstitial pulmonary disease (ILD) [ 36 ]. Decreased fatigue was associated with an improvement in the patient's perception of fatigue and increased exercise capacity [ 36 ].…”

Section: Effectiveness Of Physical Activity On Lung Tissue Immune System and Covid-19mentioning

confidence: 99%

Potential role of Nigella sativa supplementation with physical activity in prophylaxis and treatment of COVID-19: a contemporary review

et al. 2021

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The widespread prevalence and mortality of coronavirus diseases-2019 (COVID-19) lead many researchers to study the SARS-CoV-s2 infection to find a treatment for this disease. Discovering the mechanisms of action of COVID-19 and coping at the cellular level with this disease can have better effects. Including the target tissues of this disease are the lungs and the immune system. It is stated that COVID-19 easily infiltrates into alveoli through its receptors and then starts to proliferate. Subsequently, with the weakening of immune cells and increase inflammatory cytokines, it increases the rate of inflammation in the body. Strengthening the immune system and inhibiting COVID-19 receptors can play a preventive or even therapeutic role for this disease. Nigella sativa ( N. sativa ) is one of the herbal medicines to possess numerous pharmacological effects related to several organs of the body. Among the extraordinary properties of this plant is improving asthma and several lung diseases. The recent studies have shown that N. sativa at the cellular level can inhibit COVID-19 receptors. It was also stated that performing regular exercise training (especially moderate-intensity exercise training) can modulate the immune system and have an anti-inflammatory effect. Since the use of herbal supplements with exercise can have tremendous therapeutic effects at the cellular level, the hypothesis to use the Nigella sativa along with exercise training to prophylaxis and treatment COVID-19 will be highlighted in this paper.

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Changes in fatigability following intense aerobic exercise training in patients with interstitial lung disease

Cited by 20 publications

References 41 publications

Pulmonary rehabilitation in interstitial lung diseases: A review of the literature

Pulmonary rehabilitation in interstitial lung diseases: A review of the literature

Current best practice in rehabilitation in interstitial lung disease

Potential role of Nigella sativa supplementation with physical activity in prophylaxis and treatment of COVID-19: a contemporary review

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