Changes in expression of Th1 and Th2 cytokines in bovine peripheral blood mononuclear cells during early pregnancy

Yang, Ling; Wang, Yongxiang; Xingshu, MA; Wang, Songping; Zhang, Leying

doi:10.18805/ijar.5538

Cited by 10 publications

(13 citation statements)

References 22 publications

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“…In a study of 1,105 dairy herds, Charlier et al (2007) reported a negative phenotypic association, at the herd-level, between antibody response to F. hepatica and calving interval. The fact that antibody responses to both F. hepatica and O. ostertagi were favorably genetically correlated with fertility traits in the present study supports the view that animals inclined towards a TH2-type cytokine immune response have a tendency to maintain pregnancy (Oliveira et al, 2013;Zhang et al, 2015;Yang et al, 2016).…”

Section: Genetic Correlations With Fertility Traitssupporting

confidence: 84%

Genetic correlations between endo-parasite phenotypes and economically important traits in dairy and beef cattle1

Twomey

Carroll

Doherty

et al. 2018

Journal of Animal Science

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Parasitic diseases have economic consequences in cattle production systems. Although breeding for parasite resistance can complement current control practices to reduce the prevalence globally, there is little knowledge of the implications of such a strategy on other performance traits. Records on individual animal antibody responses to Fasciola hepatica, Ostertagia ostertagi, and Neospora caninum were available from cows in 68 dairy herds (study herds); national abattoir data on F. hepatica-damaged livers were also available from dairy and beef cattle. After data edits, 9,271 dairy cows remained in the study herd dataset, whereas 19,542 dairy cows and 68,048 young dairy and beef animals had a record for the presence or absence of F. hepatica-damaged liver in the national dataset. Milk, reproductive, and carcass phenotypes were also available for a proportion of these animals as well as their contemporaries. Linear mixed models were used to estimate variance components of antibody responses to the three parasites; covariance components were estimated between the parasite phenotypes and economically important traits. Heritability of antibody responses to the different parasites, when treated as a continuous trait, ranged from 0.07 (O. ostertagi) to 0.13 (F. hepatica), whereas the coefficient of genetic variation ranged from 4% (O. ostertagi) to 20% (F. hepatica). The antibody response to N. caninum was genetically correlated with the antibody response to both F. hepatica (-0.29) and O. ostertagi (-0.67); a moderately positive genetic correlation existed between the antibody response to F. hepatica and O. ostertagi (0.66). Genetic correlations between the parasite phenotypes and the milk production traits were all close to zero (-0.14 to 0.10), as were the genetic correlations between F. hepatica-damaged livers and the carcass traits of carcass weight, conformation, and fat score evaluated in cows and young animals (0.00 to 0.16). The genetic correlation between F. hepatica-damaged livers in cows and milk somatic cell score was 0.32 (SE = 0.20). Antibody responses to F. hepatica and O. ostertagi had favorable genetic correlations with fertility traits, but conversely, antibody response to N. caninum and F. hepatica-damaged livers were unfavorably genetically correlated with fertility. This study provides the necessary information to undertake national multitrait genetic evaluations for parasite phenotypes.

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Section: Genetic Correlations With Fertility Traitssupporting

confidence: 84%

Genetic correlations between endo-parasite phenotypes and economically important traits in dairy and beef cattle1

Twomey

Carroll

Doherty

et al. 2018

Journal of Animal Science

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“…We also reported that there were changing expressions of Th1 and Th2 cytokines in bovine peripheral blood mononuclear cells (PBMC) during early pregnancy [34] . It is known that macrophages play a crucial role in initiating the immune response.…”

Section: Discussionmentioning

confidence: 98%

Koyunların Erken Gebelik Döneminde Kemik iliğinde ISG15 Ekspresyonu

Yang¹,

Liu²,

Yan³

et al. 2017

Kafkas Univ Vet Fak Derg

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Interferon-tau (IFNT) is the main signal for maternal recognition of pregnancy in ruminants. IFNT acts on the endometrium, corpus luteum, and liver through paracrine and endocrine style, which is involved in inhibiting the development of luteolytic mechanism and suppressing maternal immune rejection of the semi-allogeneic fetus. Bone marrow (BM) is a key component of the lymphatic system, supports the body's immune system through producing the lymphocytes. At present study, the BM was obtained from days 13, 16 and 25 of pregnant ewes, day 16 of non-pregnant ewes to study the expression of interferon stimulated gene 15 kDa protein (ISG15) mRNA and protein through a qRT-PCR assay, Western blot, and an immunohistochemistry analysis. Our results showed that the expression of ISG15 mRNA, proteins and conjugated proteins were up-regulated in the stroma of BM during early pregnancy, and the immunohistochemistry results confirmed that the ISG15 proteins were localized in the cytoplasm of different cells in the stroma of BM. In conclusion, IFNT derived from the conceptus induced upregulated expression of ISG15 and conjugated proteins in the stroma of BM through an endocrine style, which were involved in regulating the maternal immune response during early pregnancy in ewes. Keywords: Ewes, Bone marrow, Pregnancy, Interferon stimulated gene 15 kDa protein Koyunların Erken Gebelik Döneminde Kemik İliğinde ISG15 Ekspresyonu Özetİnterferon-tau (IFNT) ruminantlarda gebeliğin maternal tanısındaki başlıca sinyaldir. IFNT endometrium, korpus luteum ve karaciğer üzerinde parakrin ve endokrin yollarla etki ederek luteolitik mekanizmanın gelişmesini inhibe eder ve semi-allojenik fetusun anne tarafından reddini baskılar. Kemik iliği lenfatik sistemin en önemli bileşenlerinden biri olup lenfositleri üretmek suretiyle vücudun bağışıklık sistemini desteklemektedir. Bu çalışmada, 13, 16 ve 25. günlerde gebe koyunlardan ve 16. günde gebe olmayan koyunlardan kemik iliği alınarak interferon tarafından uyarılan gen 15 kDa protein (ISG15) mRNA ve protein ekspresyonu qRT-PCR, Western blot ve immunohistokimyasal yöntemlerle araştırıldı. Elde edilen sonuçlar ISG15 mRNA, proteinler ile konjuge proteinlerin ekspresyonunun erken gebelik döneminde kemik iliğinde upregule edildiğini ve immunohistokimyasal olarak ISG15 proteinlerin kemik iliğinin stromasında farklı hücrelerin sitoplazmasında yer aldığını göstermiştir. Sonuç olarak, gebeliğe bağlı olarak üretilen IFNT; ISG15 ve konjuge proteinlerin ekspresyonunu kemik iliğinin stromasında endokrin yolla upregüle etmiş ve böylece koyunların erken gebelik döneminde maternal bağışıklık cevabın düzenlenmesinde rol almıştır.

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“…The spleen is an important site where IgA B-cells proliferate and differentiate because of the structure and location of this organ in systemic circulation; this organ is also complicated and regulated by cytokines and chemokines. Cytokines, such as interleukin-1 (IL-1) (Ben-Sasson et al, 2009), IL-2 (Bell et al, 2015;Yang et al, 2016), IL-6 (Ramsay et al, 1994;Zhong et al, 2019), IL-10, interferon- (IFN-) and tumour necrosis factor-α (TNF-α) (Reis et al, 2011;Dorhoi and Kaufmann, 2014), are factors necessary to develop IgA-producing B-cells. These B-cells either remove invading microorganisms by developing neutralising antibodies or eliminate viruses by activating cytotoxic T-cells (Joosten et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Cytokine Gene Expression and IgA Production in the Spleen of Chickens Infected with Eimeria tenella

Jia

Zhou

Wang

et al. 2020

IJAR

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To explore the effect of Eimeria tenella infection on the cytokines gene expression and IgA production in the spleen of chickens, the morphological characteristics of the spleen were observed through optical and transmission electron microscopy. The IgA production was determined through immunohistochemistry. The mRNA expression levels of splenic cytokines were detected through real-time PCR. Compared to the control group, along with the infection of E. tenella, the splenic lymphocytes exhibited irregular and cracked membranes, mitochondria swelled even vacuolization, the IgA expression in spleen tissue was decreased by 55.57% (p lessthan 0.01). Likewise, the mRNA expression levels of IL-2 and IL-1â decreased by 40% (plessthan 0.01) and 43% p lessthan 0.05), respectively. By contrast, the IL-6, IFN-g and IL-10 levels increased by 158% (p lessthan 0.01), 464% (p lessthan 0.05) and 379% p lessthan 0.01), respectively. These results indicated that the spleen implement an important function in the antagonism of E. tenella, which suggest a new strategy to control coccidiosis by improving the peripheral immunity of chickens.

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Changes in expression of Th1 and Th2 cytokines in bovine peripheral blood mononuclear cells during early pregnancy

Cited by 10 publications

References 22 publications

Genetic correlations between endo-parasite phenotypes and economically important traits in dairy and beef cattle1

Genetic correlations between endo-parasite phenotypes and economically important traits in dairy and beef cattle1

Koyunların Erken Gebelik Döneminde Kemik iliğinde ISG15 Ekspresyonu

Cytokine Gene Expression and IgA Production in the Spleen of Chickens Infected with Eimeria tenella

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