Changes in Erythrocytic Membrane Free Energy of Albino Rabbits Administered Ethanol Leaf Extract of Spondias mombin Linn

Igwe, C. U.

doi:10.9734/ejmp/2012/1062

Cited by 4 publications

(4 citation statements)

References 17 publications

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“…The ionic current that maintains this resting membrane potential of cells and the changes that occur in response to the presence of a disease condition, pharmacologic or signaling molecules constitute the complex electrophysiologic network that controls the pathophysiological process of any given disease, the contractile activity of smooth muscle, signal transduction of a nerve cell, among others. 29,30 The results of this study (Table 2) showed that neither pre-eclampsia nor pregnancy significantly affected the calculated free energy changes associated with divalent cation transport. This observation could be attributed to the absence of certain subcellular organelles such as sarcoplasmic reticulum and plasmalemma in erythrocytes which are necessary for storage of these cations, especially calcium, within cells.…”

Section: Resultsmentioning

confidence: 69%

“…Unlike the other cations studied, a negative erythrocyte membrane free energy was obtained for calcium which corroborated similar observation with normal erythrocytes from albino rabbits. 29 This indicates that membrane free energy studies using changes in calcium concentrations may offer better empirical evidence than the use of the other divalent cations. Interestingly, the negative membrane free energy values obtained using calcium was not affected by both pre-eclampsia and pregnancy.…”

Section: Resultsmentioning

confidence: 99%

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Effect of Pre-Eclampsia on plasma and erythrocytic divalent cation concentrations and their Bioenergetics of Transport

et al. 2014

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Background: Pre-eclampsia is a syndrome of pregnancy-induced hypertension with proteinuria, which has high prevalence rate among blacks.Aims and Objectives:To study the effect of pre-eclampsia on bioenergetics for the transport of erythrocytic cations to plasma, the plasma and erythrocytic levels of magnesium (Mg), calcium (Ca), copper (Cu), zinc (Zn), manganese (Mn) and selenium (Se) were measured by atomic absorption spectrophotometry in 100 pre-eclamptic women matched for gestation age with 100 normal pregnant subjects. These were also age-matched with 100 non-pregnant women.Results: The plasma and erythrocytic levels of the minerals were significantly (p < 0.05) lower in the pre-eclamptic patients than the healthy pregnant and the non-pregnant women. Although, levels of these minerals were also reduced in the healthy pregnant women relative to the non-pregnant subjects, only the plasma and erythrocytic levels of Ca, Cu, Mn and Se showed significant (p < 0.05) depreciations. Pre-eclampsia and pregnancy did not affect significantly (p > 0.05) the divalent-cation-based erythrocytic membrane free energy.Conclusion: Our results suggest that low levels of these minerals, especially Mg and Ca in pre-eclampsia, may have roles to play in the development of hypertension in these patients, and calls for intensified research into mineral supplementation as a key for possible prevention or management of pre-eclampsia.DOI: http://dx.doi.org/10.3126/ajms.v6i2.11109Asian Journal of Medical Sciences Vol.6(2) 2015 19-24

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Section: Resultsmentioning

confidence: 69%

Section: Resultsmentioning

confidence: 99%

Effect of Pre-Eclampsia on plasma and erythrocytic divalent cation concentrations and their Bioenergetics of Transport

et al. 2014

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“…Alkaloids are a class of plant-friendly compounds. They are useful for warding off parasites and predators [38] and have also been shown to have anti-asthmatic, anticancer, and antimalarial properties [39] .While alkaloids can be toxic, they have been shown to have vasodilatory, antihyperglycemic, cholinomimetic, antiarrhythmic [40], antimicrobial, and analgesic characteristics [41,42] . Tannins are important secondary metabolites of plants with different medicinal importance.…”

Section: Discussionmentioning

confidence: 99%

Phytochemical and nutritional composition of ethanol-water leaf extracts of Justicia secunda and Jatropha tanjorensis

Collins Obinna Keke,

Linus Ahuwaraeze Nwaogu,

Chidi Uzoma Igwe

et al. 2023

GSC Biol. Pharm. Sci.

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The study analyzed phytochemical and nutritional compositions of ethanol-water leaf extracts of Justicia secunda and Jatropha tanjorensis using standard methods. In both plants significant amounts of alkaloids, tannin and flavonoids were seen. J. tanjorensis had higher amount of saponin and cardiac glycoside. The quantitative phytochemical and anti-nutrient evaluation revealed J.tanjorensis had higher amount of phytochemicals including sapogenin, anthocyanin and anti-nutrient factors such as tannin, phytate and oxalate. The proximate analysis yielded carbohydrate as being most abundant in both plants with J.tanjorensis having higher (62.22 ±0.14%) against (61.52±0.12 %) seen in J.secunda. Fibre composition of both plants was low with 4.62±0.04% in J.secunda and 5.22±0.05% in J.tanjorensis. The most prevalent mineral element in J.secunda was magnesium (9.39±0.10mg/kg dry weight) while potassium (8.58±0.10mg/kg dry weight) was most prevalent in J.tanjorensis. Manganese was the least abundant in both plants. Eighteen different amino acids were found. His (4.76 ±0.08 µg/g) was the most abundant essential amino acid (EAA) in J.secunda, while Phe (5.78 0.04 µg/g) was the most abundant EAA in J.tanjorensis. Gly (4.85±0.03µg/g) and Pro (4.78±0.04 µg/g) was the most prevalent NEAAs in J.secunda and J.tanjorensis, respectively. The finding validates the richness of both plants in essential phytochemicals and other beneficial plant-based nutrients, and explains their traditional use in forkloric medicine practice.

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“…Serum sodium was estimated by the colorimetric method outlined by Igwe et al (2020). Briefly, 1.0 ml of filtrate reagent was pipetted into test tubes labeled as blank, standard, and sample.…”

Section: Estimation Of Serum Sodium Concentrationmentioning

confidence: 99%

Therapeutic effect of the solvent fraction of hexane leaf extract of Tapinanthus bangwensis (Engl. & K. Krause) (Loranthaceae) in alloxan-induced pathology in diabetic rats

Ihegboro,

Ononamadu,

Fadilu

et al. 2024

Int. J. Plant Based Pharm.

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Plant-based products are gradually replacing pharmaceuticals in treating ailments, including diabetes, due to their safety, cost-effectiveness, potency, and availability. Therefore, the current study looked into the therapeutic effect of the solvent fraction of hexane leaf extract of Tapinanthus bangwensis (HEXETACF) (Loranthaceae) in alloxan-induced pathology in diabetic rats. The biochemical parameters were estimated using analytical grade kits via spectrophotometric method. The laboratory rats were distributed into group W (five rats on feed and water), group X (seven rats + 150 mg/kg alloxan solution only), group Y (seven rats + 150 mg/kg alloxan solution + 200 mg/kg BW silymarin for 21 days), and group Z (seven rats + 150 mg/kg alloxan solution + 250 mg/kg BW HEXETACF for 21 days). The results showed that HEXETACF and silymarin (SILY) reduced blood glucose concentration by 33.77% and 34.80%, respectively, after the 21st day of treatment (p < 0.05). Additionally, alkaline phosphatase (ALP) and alanine aminotransferase (ALT) activity in SILY and HEXETACF were significantly decreased compared to the diabetic group (p < 0.05), but no significant decrease in aspartate aminotransferase (AST) activity was observed between the test samples and the diabetic group. Furthermore, the test samples lowered malondialdehyde (MDA) levels, by improving glutathione, superoxide dismutase (SOD), and catalase (CAT) activity. The HEXETACF and SILY significantly decreased triglyceride levels (TG) compared to the diabetic group at p < 0.05. They also reduced low-density lipoprotein (LDL) and cholesterol levels and increased the high-density lipoprotein levels compared to the diabetic group. Additionally, no significant decrease in serum electrolytes (Na+, K+, and Cl-), urea, and creatinine (including albumin and total protein) values was observed in HEXETACF and SILY, while hematological indices increased compared to the diabetic group. Histology results revealed that the test samples had normalized glomeruli, β-islet cells, and hepatocytes. However, a trace of mild congestion was noticed in the STDG. But edemic blood congestion was observed in the diabetic group. In conclusion, the current result demonstrated that HEXETACF may be a promising antidiabetic agent that could replace mSILY.

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Changes in Erythrocytic Membrane Free Energy of Albino Rabbits Administered Ethanol Leaf Extract of Spondias mombin Linn

Cited by 4 publications

References 17 publications

Effect of Pre-Eclampsia on plasma and erythrocytic divalent cation concentrations and their Bioenergetics of Transport

Effect of Pre-Eclampsia on plasma and erythrocytic divalent cation concentrations and their Bioenergetics of Transport

Phytochemical and nutritional composition of ethanol-water leaf extracts of Justicia secunda and Jatropha tanjorensis

Therapeutic effect of the solvent fraction of hexane leaf extract of Tapinanthus bangwensis (Engl. & K. Krause) (Loranthaceae) in alloxan-induced pathology in diabetic rats

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