Changes in emotional behavior produced by orexin microinjections in the paraventricular nucleus of the thalamus

Li, Yonghui; Li, Sa; Wei, Chuguang; Wang, Huiying; Song, Nan; Kirouac, Gilbert J.

doi:10.1016/j.pbb.2009.12.016

Cited by 74 publications

(39 citation statements)

References 59 publications

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“…In fact, we recently reported that microinjections of OXA in the PVT region of rats increased freezing and grooming (Li et al 2009), behaviors associated with fearful and aversive situations. We also reported that microinjections of both OXA and OXB in the PVT region produced an anxiety-like response in animals tested in an open field (Li et al 2010). As such, these pharmacological studies suggest that orexins may act on the PVT to regulate negative emotional behavior.…”

Section: Introductionmentioning

confidence: 60%

“…This does not appear to be the case because orexin administrations in the thalamus did not have any effect on locomotor activity, which is normally elevated in animals in heightened states of arousal (Pfaff et al 2008). In fact, we previously reported that microinjections of orexins in the PVT produced a weak inhibition of locomotion while increasing grooming and freezing (Li et al 2009(Li et al , 2010. A more likely explanation is that administrations of orexins in the PVT may have produced arousal effects that are specific to neurons that regulate emotional behaviors like anxiety.…”

Section: Discussionmentioning

confidence: 93%

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Orexins in the paraventricular nucleus of the thalamus mediate anxiety-like responses in rats

et al. 2010

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Section: Introductionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 93%

Orexins in the paraventricular nucleus of the thalamus mediate anxiety-like responses in rats

et al. 2010

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“…In addition, Orx/Hcrt neurons become activated (i.e., increased Fos) after exposure to stress (Espana et al, 2003;Furlong et al, 2009), which indicates that the Orx/Hcrt system is involved in the expression of behavioral and physiologic responses to stressful events. Supporting this hypothesis, both Orx-A/Hcrt-1 and Orx-B/Hcrt-2, when injected in the PVT, produce anxiety-like behavior in rats observed in the open field (Li et al, 2010a) or in the elevated plus maze (Li et al, 2010b), suggesting that Orx/Hcrt can act as a stressor and can therefore precipitate cocaine-seeking behavior.…”

Section: Discussionmentioning

confidence: 80%

Orexin-A/Hypocretin-1 Mediates Cocaine-Seeking Behavior in the Posterior Paraventricular Nucleus of the Thalamus via Orexin/Hypocretin Receptor-2

Matzeu

Kerr

Weiss

et al. 2016

J Pharmacol Exp Ther

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Orexin/hypocretin (Orx/Hcrt) projections from the lateral hypothalamus to the paraventricular nucleus of the thalamus (PVT) are implicated in drug addiction. Specifically, the posterior section of the PVT (pPVT) innervates brain structures that modulate motivated behavior. This study investigated the role of pPVTOrx/Hcrt transmission in cocaine-seeking behavior. Because the effects of Orx/Hcrt are mediated by two Orx/Hcrt receptors (Hcrt-r1 and Hcrt-r2), we examined the extent to which Hcrt-r1 and Hcrt-r2 are involved in Orx/Hcrt-induced cocaine seeking. Male Wistar rats were made cocaine dependent by selfadministering cocaine 6 hours/day (long access) for 21 days. After self-administration training, the rats underwent daily extinction training, during which cocaine was withheld. After extinction, the rats were injected into the pPVT with Orx-A/Hcrt-1 (0-2 mg) alone or, using a single dose of 0.5 mg, in combination with an Hcrt-r1 antagonist (SB334867; 0-15 mg) or an Hcrt-r2 antagonist (TCSOX229; 0-15 mg). Orx-A/Hcrt-1 alone reinstated (primed) cocaine seeking. Unexpectedly, coadministration of Orx-A/Hcrt-1 with SB334867 did not have any effects on Orx-A/Hcrt-1-induced reinstatement, whereas when coadministered with Orx-A/Hcrt-1, TCSOX229 prevented cocaine-seeking behavior. These results indicate that Hcrt-r2 in the pPVT mediates the reinstating effect of Orx-A/Hcrt-1 in animals with a history of cocaine dependence and further identify Hcrt-r2 as a possible molecular target that can guide future therapeutic approaches for the prevention of drug-seeking behavior.

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“…Moreover, orexin signalling in PVT may generate an aversive motivational state [121][122][123] and antagonism of OX 2 R in PVT blocks conditioned place aversion produced by naloxone-precipitated morphine withdrawal [124]. In summary, increasing evidence supports a role for PVT in reinstatement of extinguished drug seeking.…”

Section: R In Pvt Hadmentioning

confidence: 94%

The hypothalamus and the neurobiology of drug seeking

Marchant

Millan

McNally

2011

Cell. Mol. Life Sci.

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The hypothalamus is a neural structure critical for expression of motivated behaviours that ensure survival of the individual and the species. It is a heterogeneous structure, generally recognised to have four distinct regions in the rostrocaudal axis (preoptic, supraoptic, tuberal and mammillary). The tuberal hypothalamus in particular has been implicated in the neural control of appetitive motivation, including feeding and drug seeking. Here we review the role of the tuberal hypothalamus in appetitive motivation. First, we review evidence that different regions of the hypothalamus exert opposing control over feeding. We then review evidence that a similar bi-directional regulation characterises hypothalamic contributions to drug seeking and reward seeking. Lateral regions of the dorsal tuberal hypothalamus are important for promoting reinstatement of drug seeking, whereas medial regions of the dorsal tuberal hypothalamus are important for inhibiting this drug seeking after extinction training. Finally, we review evidence that these different roles for medial versus lateral dorsal tuberal hypothalamus in promoting or preventing reinstatement of drug seeking are mediated, at least in part, by different populations of hypothalamic neurons as well as the neural circuits in which they are located.

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Changes in emotional behavior produced by orexin microinjections in the paraventricular nucleus of the thalamus

Cited by 74 publications

References 59 publications

Orexins in the paraventricular nucleus of the thalamus mediate anxiety-like responses in rats

Orexins in the paraventricular nucleus of the thalamus mediate anxiety-like responses in rats

Orexin-A/Hypocretin-1 Mediates Cocaine-Seeking Behavior in the Posterior Paraventricular Nucleus of the Thalamus via Orexin/Hypocretin Receptor-2

The hypothalamus and the neurobiology of drug seeking

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