Changes in electrical activity of heart during ischemic–reperfusion injury modified by the administration of antidepressants

Vicen, Matej; Gulac, Patrik; Stankovičová, T

doi:10.1515/afpuc-2016-0006

Cited by 1 publication

(2 citation statements)

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“…On the other hand, after the switch to the standard diet, the threshold for sustained VT/VF was markedly higher and the restoration of the sinus rhythm was more rapid. Vicen et al (2016) showed that venlafaxine administered in a single dose to Wistar rats caused a significantly higher incidence of life-threatening dysrhythmias, compared to the control group. In clinical practice, venlafaxine showed a potential to induce tachycardia in a dose-dependent manner (Abozguia et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

“…However, there is evidence that antidepressants, including venlafaxine, are independently associated with the worsening or even development of MetS, by an increase in systolic and diastolic blood pressure, as well as in LDL cholesterol levels and body weight (McIntyre et al, 2010). Moreover, venlafaxine itself may cause cardiac electrical disturbances, such as QT interval and QRS complex prolongation or lethal forms of dysrhythmias (Khalifa et al, 1999;Bavle, 2015;Vicen et al, 2016;Sasváriová et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

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The effect of venlafaxine on blood pressure and ECG in rats fed with high-fat-fructose diet

Sasváriová

Michalikova

Kaprinay

et al. 2019

Interdisciplinary Toxicology

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Metabolic syndrome represents one of the major health, social and economic issues nowadays, and affects more than 25% people worldwide. Being a multifactorial health problem, metabolic syndrome clusters various features, such as obesity, dyslipidemia, hyperglycemia and hypertension. Each of these disturbances represents a risk factor for developing cardiovascular disease. Moreover, patients with metabolic syndrome are more likely to suffer from depression, thus treatment with antidepressants (e.g. venlafaxine) is often neccessary. However, many of the antidepressants themselves may contribute to worsening or even development of the metabolic syndrome, thus creating a “vicious circle”. The aim of this work was to investigate on the animal model of metabolic syndrome, i.e. on hypertriacylglycerolemic rats fed high-fat-fructose diet (HFFD): 1) the effect of a change in diet from HFFD to a standard diet (SD) and the effect of venlafaxine treatment, 2) during HFFD, 3) as well as during a changed diet to SD. We focused on biometric parameters, blood pressure and selected ECG parameters. We observed the reversibility of the present metabolic and cardiovascular changes by switching the HFFD to SD in the last 3 weeks of the experiment. Switch to the standard diet led to decrease of body weight, even in the presence of venlafaxine. Administration of venlafaxine caused the decrease of heart weight/body weight index in rats fed with HFFD compared to the untreated group fed with HFFD for 8 weeks. Blood pressure, which was increased in the HFFD group showed a tendency to decrease to control values after switching to the standard diet. Administration of venlafaxine led to significant increase in all parameters of blood pressure when rats were fed with HFFD throughout the whole experiment. In untreated rats fed with HFFD for 8 weeks, we observed a shorter PQ interval and prolonged QRS complex as well as QTc interval compared to untreated rats with diet switched to SD. This effect was potentiated by venlafaxine administered not only during HFFD but even after switch to SD. Our results point to the fact that metabolic syndrome is clearly affecting the function of the cardiovascular system by modifying blood pressure and electrical activity of the heart. Moreover, administration of venlafaxine may lead to worsening of the observed changes, especially in the presence of high-fat-fructose diet.

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Section: Discussionmentioning

confidence: 99%