Changes in Ejection Fraction and Global Longitudinal Strain Assessment in Patients With Heart Failure With Reduced Ejection Fraction After Therapy With Sacubitril/Valsartan

Sacubitril/Valsartan Induces Global Cardiac Reverse Remodeling in Long-Lasting Heart Failure with Reduced Ejection Fraction: Standard and Advanced Echocardiographic Evidences

“…So far, data regarding advanced echocardiography parameters and the proportion of patients on sacubitril/valsartan undergoing a complete LVRR and LARR adopting well defined criteria already published in the literature [2,10], still lack. In fact, despite some clinical reports demonstrated a possible improvement of LVGLS [17] in this setting, they evaluated a very small sample of patients and only a minority (4%) were taking the highest dose of the drug, whilst it has been reported that the amount of LV improvement on sacubitril valsartan might be dose dependent [18].…”