Changes in EEG and Reaction Times during the Treatment of Apathetic Depression

Изнак, А. Ф.; Изнак, Е. В.; Sorokin, S. A.

doi:10.1007/s11055-012-9694-8

Cited by 18 publications

(12 citation statements)

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“…Upon clinical improvement, the accent of the Δ activity shifts to the anterior areas of the right hemisphere, and the clinical estimates of the manifestation of residual depressive symptoms are negatively correlated to the spectral power of the α rhythm in the right hemi sphere. These results indicate normalization of inter hemispheric relationships and coincide with our ear lier data on the dynamics of interhemispheric rela tionships during treatment of various forms of depression in various age groups of patients [15][16][17][18][19] and agree with classical and modern concepts on the predominant role of the right hemisphere of the brain in the regulation of negative emotions and in the pathogenesis of depression [20][21][22][23][24][25][26].…”

Section: Discussionsupporting

confidence: 87%

EEG correlates and possible predictors of the efficacy of the treatment of endogenous depression

et al. 2013

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Analysis of EEG spectral power values and quantitative clinical scores of depressive conditions has been carried out in the dynamics of the treatment of 40 patients with endogenous depression, with the main goal to study the neurophysiological correlates and to search for possible predictors of therapeutic out come. The reduction of depressive symptoms by the end of the treatment course was associated with EEG signs of improvement of the brain's functional state. Significant correlations have been revealed between the EEG narrow band spectral power values and clinical scores. As well, significant correlations have been revealed between some initial (before the beginning of the treatment) EEG parameters and quantitative clin ical scores at the initial stage of remission. The values of EEG β 1 and β 2 spectral power appeared to be pre dictors, while initially larger values of EEG spectral power were associated with the high manifestation of residual depressive symptoms after the treatment. The results support the basic views on the brain's mecha nisms of various aspects of depressive disorders and reveal the possible neurophysiological predictors of the efficacy of the treatment of endogenous depression.

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Section: Discussionsupporting

confidence: 87%

EEG correlates and possible predictors of the efficacy of the treatment of endogenous depression

et al. 2013

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“…In which Baskaran et al found that escitalopram responders showed greater delta power in the right hemisphere at 2-week of escitalopram treatment (Baskaran et al 2018). Additionally, right lateralization of delta in escitalopram responders are similar to reports of increased slow wave activity in the right hemisphere in MDD patients (Iznak and Sorokin 2013). Therefore, this feature may reflect a subtype of MDD patients that respond well to escitalopram.…”

Section: Discussionsupporting

confidence: 80%

Spatio-temporal dynamics of EEG features during sleep in major depressive disorder after treatment with escitalopram: A pilot study

Wang

Yang³

et al. 2020

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Background: Previous studies have shown escitalopram is related to sleep quality. However, effects of escitalopram on dynamics of electroencephalogram (EEG) features especially during different sleep stages have not been reported. This study may help to reveal pharmacological mechanism underlying escitalopram treatment. Methods:The spatial and temporal responses of patients with major depressive disorder (MDD) to escitalopram treatment were analyzed in this study. Eleven MDD patients and eleven healthy control subjects who completed eight weeks' treatment of escitalopram were included in the final statistics.Six-channel sleep EEG signals were acquired during sleep. Power spectrum and nonlinear dynamics were used to analyze the spatio-temporal dynamics features of the sleep EEG after escitalopram treatment.Results: For temporal dynamics: after treatment, there was a significant increase in the relative energy (RE) ofA band (0.5 -2Hz), accompanied by a significant decrease in the RE ofb band (20 -30Hz). Lempel-Ziv complexity and Co -complexity values were significantly lower. EEG changes at different sleep stages also showed the same regulation as throughout the night sleep. For spatio dynamics: after treatment, the EEG response of the left and right hemisphere showed asymmetry.Regarding band-specific EEG complexity estimations, δ1 and β2 in stage-1 and δ1 in stage-2 sleep stage in frontal cortex is found to be much more sensitive to escitalopram treatment in comparison to central and occipital cortices. Conclusions:The sleep quality of MDD patients improved, EEG response occurred asymmetry in left and right hemispheres due to escitalopram treatment, and frontal cortex is found to be much more sensitive to escitalopram treatment. These findings may contribute to a comprehensive understanding of the pharmacological mechanism of escitalopram in the treatment of depression.

show abstract

Section: Discussionsupporting

confidence: 80%

Spatio-temporal dynamics of EEG features during sleep in major depressive disorder after treatment with escitalopram:A pilot study

Wang

Yang

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Previous studies have shown escitalopram is related to sleep quality. However， effects of escitalopram on dynamics of electroencephalogram (EEG) features especially during different sleep stages have not been reported. T his study may help to reveal pharmacological mechanism underlying escitalopram treatment . Methods: The spatial and temporal responses of patients with major depressive disorder (MDD) to escitalopram treatment were analyzed in this study. Eleven MDD patients and eleven healthy control subjects who completed eight weeks’ treatment of escitalopram were included in the final statistics. Six-channel sleep EEG signals were acquired during sleep. Power spectrum and nonlinear dynamics were used to analyze the spatio-temporal dynamics features of the sleep EEG after escitalopram treatment. Results: For temporal dynamics: after treatment, there was a significant increase in the relative energy (RE) of band (0.5 - 2Hz), accompanied by a significant decrease in the RE of band (20 - 30Hz). Lempel-Ziv complexity and Co - complexity values were significantly lower. EEG changes at different sleep stages also showed the same regulation as throughout the night sleep. For spatio dynamics: after treatment, the EEG response of the left and right hemisphere showed asymmetry. Regarding band-specific EEG complexity estimations, δ1 and β2 in stage-1 and δ1 in stage-2 sleep stage in frontal cortex is found to be much more sensitive to escitalopram treatment in comparison to central and occipital cortices. Conclusions: The sleep quality of MDD patients improved, EEG response occurred asymmetry in left and right hemispheres due to escitalopram treatment, and frontal cortex is found to be much more sensitive to escitalopram treatment. These findings may contribute to a comprehensive understanding of the pharmacological mechanism of escitalopram in the treatment of depression.

show abstract

Changes in EEG and Reaction Times during the Treatment of Apathetic Depression

Cited by 18 publications

References 1 publication

EEG correlates and possible predictors of the efficacy of the treatment of endogenous depression

EEG correlates and possible predictors of the efficacy of the treatment of endogenous depression

Spatio-temporal dynamics of EEG features during sleep in major depressive disorder after treatment with escitalopram: A pilot study

Spatio-temporal dynamics of EEG features during sleep in major depressive disorder after treatment with escitalopram:A pilot study

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