Changes in disability in people with multiple sclerosis: a 10-year prospective study

Conradsson, David; Ytterberg, Charlotte; Koch, Lena von; Johansson, Sverker

doi:10.1007/s00415-017-8676-8

Cited by 63 publications

(54 citation statements)

References 39 publications

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“…In contrast, inconsistent findings have been reported with regard to participation in more complex social/lifestyle activities (e.g. work and social occasions); most studies have shown restricted participation in people with MS across 10 years [3,14,15] whereas others have demonstrated sustained [4] or improved participation [16]. The aforementioned longitudinal studies have reported changes in the sum score of items compromising instruments assessing ADL or participation.…”

Section: Introductionmentioning

confidence: 99%

“…Multiple sclerosis (MS) is a neuroinflammatory demyelinating disease causing progressive disability and resulting in a substantial burden for the individual and society [1,2]. As MS progresses, people with MS experience reduced ability to perform activities of daily living (ADL) and to participate in various life situations [2][3][4][5][6]; which in turn have a negative impact on their quality of life [2,7,8]. MS often results in different types of disability (e.g.…”

Section: Introductionmentioning

confidence: 99%

“…feeding) and instrumental ADL (e.g. cleaning) over 10 years [3,4]. In contrast, inconsistent findings have been reported with regard to participation in more complex social/lifestyle activities (e.g.…”

Section: Introductionmentioning

confidence: 99%

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Activity limitations and participation restrictions in people with multiple sclerosis: a detailed 10-year perspective

Conradsson

Ytterberg

Engelkes

et al. 2019

Disability and Rehabilitation

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Aim: To conduct a detailed investigation into changes in activity limitations and participation restrictions over 10 years in people with mild, moderate and severe multiple sclerosis. Methods: This study was a 10-year longitudinal study of 264 people with multiple sclerosis living in Stockholm County, Sweden. Ten-year changes in personal and instrumental activities in daily living were assessed using the Katz Activities in Daily Living Index Extended and participation in social/lifestyle activities using the Frenchay Activities Index. Results: While people with moderate multiple sclerosis, compared to baseline, demonstrated significantly higher proportions of dependency in most activities of personal and instrumental activities in daily living at the 10-year follow-up, the mild group primarily increased their dependency in instrumental activities and the severe group in personal activities. Significantly higher proportions of the moderate group showed restricted participation in domestic and outdoor activities whereas the mild group only showed restrictions in a few domains of participation. A majority of people with severe multiple sclerosis showed restricted participation in all social/lifestyle activities at baseline and the 10-year follow-up. Conclusions: Prominent long-term increases in activity limitations and participation restrictions occurred across the spectrum of disease severity but was most pronounced in those more moderately affected. ä IMPLICATIONS FOR REHABILITATION This study provides guidance with regard to specific activities that are prone to deteriorate across 10 years and thereby reflect important targets and outcomes for interventions. Increases in activity limitations and participation restrictions were most pronounced in those moderately affected by multiple sclerosis. Those mildly affected by multiple sclerosis primarily increased their dependency in instrumental activities of daily living while those severely affected increased their dependency in personal activities of daily living.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Activity limitations and participation restrictions in people with multiple sclerosis: a detailed 10-year perspective

Conradsson

Ytterberg

Engelkes

et al. 2019

Disability and Rehabilitation

Self Cite

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show abstract

“…Multiple Sclerosis (MS), is a neurodegenerative disorder that affects all aspects of life [1][2][3]. Fluctuating symptoms and a variable decline in functioning, can differentially impact upon perceived quality of life [4] .…”

Section: Introductionmentioning

confidence: 99%

The WHOQOL-BREF: a modern psychometric evaluation of its internal construct validity in people with multiple sclerosis

et al. 2020

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Purpose Symptoms of Multiple Sclerosis (MS) differentially impact upon quality of life (QoL) and a comprehensive measure is required for use in observational and interventional studies. This study examines the abbreviated World Health Organisation Quality of Life tool (WHOQOL-BREF) which was designed to be used as a broad measure of QoL across different cultures and diseases. Methods Data were collected from 3186 subjects as part of the TONiC study in MS and was examined with a systematic, iterative approach using Rasch analysis to investigate the internal construct validity of the WHOQOL-BREF. Results Mean age was 49.8 years (SD 11.8), disease duration was 11.2 years (SD 9.6) and 73.2% were female. Subjects represented all stages of MS with EDSS scores of 0-4, 4.5-6.5, 7-7.5 and ≥ 8 seen in 49.8%, 38.5%, 6.8% and 4.9% of patients, respectively. Using a super-item approach, it was possible to demonstrate fit to the assumptions of the Rasch model for 3 of the 4 domains of the WHOQOL-BREF (physical, psychological and environment) as well as a broad 24-item total score. In addition, item subsets derived from the stem of each question were shown to function as novel scales measuring impact and life satisfaction. We have provided transformation tables from ordinal raw scores to interval scales where data are complete. Conclusions The validation of multiple conceptual frameworks validates the WHOQOL-BREF as a powerful and flexible end-point for use in clinical trials and in testing conceptual models of factors influencing QoL in MS.

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“…This can be assessed using the Frenchay Activities Index (FAI), which provides an effective evaluation method that captures an individual's status of activities and participation. The FAI was originally developed to assess the status of instrumental activities of daily living (IADL) for stroke patients [12], and many studies have been conducted with patients with various illnesses and injuries, including lower limb amputation [13], multiple sclerosis [14], and spinal cord injury [15], and it has also been applied to the general elderly population [16]. The validity and reliability of various country-specific translations of the scales have been confirmed, including, for the Japanese, Chinese, and Korean versions [17] [18] [19].…”

Section: Introductionmentioning

confidence: 99%

Determination of a Cut-Off Point of a Scale for Achievement Motive in Geriatrics That Predicts the Frequency of Undertaking Instrumental Activities of Daily Living in Community-Dwelling Elderly People

Nakazono¹,

Sano²

2019

AAR

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Background: Among elderly people, rehabilitation is important for reducing the risk of falls and hospitalization and to maintain an independent life for longer. Motivation is a factor for elderly people to lead an active daily life and leave home more frequently. Purpose: The purposes of this study were to determine the optimal cutoff point in the Scale for Achievement Motive in Geriatrics (SAMG) that could identify individuals as inactive or active, based on the Frenchay Activities Index (FAI), and to compare characteristics between active and inactive groups classified by the cutoff point. Methods: A cross-sectional study of 285 community-dwelling elderly people measured SAMG and FAI and physical function. Receiver operating characteristic (ROC) analysis was used to calculate the area under the curve (AUC) that was the optimal cutoff point for the SAMG total score, with the associated sensitivity and 1-specificity when compared with the FAI results. Demographic parameters and physical function were compared between two groups defined by cutoff point. Results: The AUC was 0.78, the optimal cutoff for SAMG total score for indicating inactivity was ≤48, the sensitivity was 77.98% and the 1-specificity was 75.00%. The group with SAMG score >48 was characterized by a significantly higher proportion of women, fewer people sharing a house, and participation in more hobbies. Discussion: A cutoff point of 48 in the SAMG could be a predictive index of motivation toward goals for individuals with inactive daily activities. The group with score higher than the cutoff was characterized by more women, fewer people living together, and more hobbies than the group with lower scores.

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Changes in disability in people with multiple sclerosis: a 10-year prospective study

Cited by 63 publications

References 39 publications

Activity limitations and participation restrictions in people with multiple sclerosis: a detailed 10-year perspective

Activity limitations and participation restrictions in people with multiple sclerosis: a detailed 10-year perspective

The WHOQOL-BREF: a modern psychometric evaluation of its internal construct validity in people with multiple sclerosis

Determination of a Cut-Off Point of a Scale for Achievement Motive in Geriatrics That Predicts the Frequency of Undertaking Instrumental Activities of Daily Living in Community-Dwelling Elderly People

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