Changes in Dietary Intake in Pregnant Women from Periconception to Pregnancy in the Japan Environment and Children’s Study: A Nationwide Japanese Birth Cohort Study

Ishitsuka, Kazue; Sasaki, Satoshi; Yamamoto‐Hanada, Kiwako; Mezawa, Hidetoshi; Konishi, Mizuho; Ohya, Yukihiro

doi:10.1007/s10995-019-02835-z

Cited by 11 publications

(12 citation statements)

References 33 publications

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“…FA supplements are recommended for pregnant women in early pregnancy in Japan [33]. Furthermore, the proportion of FA intake during early pregnancy in this study was higher than that reported in a previous study of Japanese pregnant women [34][35][36], which may be why concentrations of 5-MTHF in the present study were close to those of Bodnar et al Serum 5-MTHF and FA in Japanese pregnant women were mostly lower than those in populations from regions with mandatory FA fortification, due to the expected effects of FA exposure, as mentioned in previous studies [9].…”

Section: Discussioncontrasting

confidence: 58%

Distribution of 5-Methyltetrahydrofolate and Folic Acid Levels in Maternal and Cord Blood Serum: Longitudinal Evaluation of Japanese Pregnant Women

et al. 2020

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“Total” folate in blood has usually been measured to evaluate the folate status of pregnant women. However, folate is composed of many metabolites. The main substrate is 5-methyltetrahydrofolate (5-MTHF), with folic acid (FA) representing a very small component as an unmetabolized species in blood. We longitudinally evaluated 5-MTHF, FA and total homocysteine in maternal and cord blood from Japanese pregnant women. Subjects were 146 pregnant women who participated in the Chiba study of Mother and Child Health (C-MACH) prospective cohort study. Sera were obtained in early and late pregnancy, at delivery, and from cord blood. Species levels were measured by isotope-dilution mass spectrometry. Both 5-MTHF and FA levels were lower than reported levels from pregnant women in populations from countries with mandatory FA fortification. As gestational age progressed, serum 5-MTHF levels decreased, whereas serum FA levels were slightly reduced only at delivery compared to early pregnancy. A significant negative association between serum 5-MTHF and total homocysteine was shown at all examined times, but no associations with FA were evident. At delivery, cord 5-MTHF was significantly higher than maternal levels, while FA again showed no significant correlation. These results suggest that 5-MTHF is actively transported to the fetus through placental transporters and may reflect folate status during pregnancy as a physiologically important species.

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Section: Discussioncontrasting

confidence: 58%

Distribution of 5-Methyltetrahydrofolate and Folic Acid Levels in Maternal and Cord Blood Serum: Longitudinal Evaluation of Japanese Pregnant Women

et al. 2020

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“…For example, folic acid supplementation in the preconception period can reduce neural tube defects by up to 70% [ 35 ]. We previously demonstrated poor folic acid usage in UK women planning pregnancy [ 11 ], which is consistent with other reports [ 36 , 37 ].…”

Section: Discussionsupporting

confidence: 91%

Community Pharmacist-Led Interventions to Improve Preconception and Pregnancy Health: A Systematic Review

et al. 2021

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Background: Community pharmacist-led interventions are effective in improving health outcomes; however, their impact in improving preconception and pregnancy health is not clear. This study evaluated the effectiveness of community pharmacist-led interventions which aimed to improve health outcomes of preconception and pregnant women. Methods: A systematic review of the literature, consistent with PRISMA guidelines, was performed. Five electronic databases were searched up to February 2021. Results: Four studies, three in pregnant women and one in preconception women, were identified. The studies focused on improving micronutrient status and smoking cessation. The studies increased knowledge about, and use of, iron supplements, and improved iron status and smoking cessation rates in pregnant women, while improving knowledge regarding, and increasing the use of, preconception folic acid. The studies were ranked as weak to moderate quality. Conclusion: This review provides preliminary evidence for the potential benefit of community pharmacist-led interventions to improve the health of women before and during pregnancy.

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“…In Asian countries, including Japan and China, soy is commonly consumed during pregnancy (Li et al 2011;Miyake et al 2005). Ishitsuka et al, (2020) recently reported that among Japanese women, during pregnancy, pulse intake, which in Japan is represented primarily by soy products, is similar to the intake prior to pregnancy. Miyake et al (2005) reported that the genistein and daidzein intake (mean ± SD) of 1,002 pregnant Japanese women participating in the Japan Osaka Maternal and Child Health Study was 15.0 ± 10.1 mg/d and 9.0 ± 6.1 mg/d, respectively.…”

Section: Fetal Effects Of Maternal Soy/isoflavone Intakementioning

confidence: 99%

Neither soyfoods nor isoflavones warrant classification as endocrine disruptors: a technical review of the observational and clinical data

Messina

Mejía

Cassidy

et al. 2021

Critical Reviews in Food Science and Nutrition

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Soybeans are a rich source of isoflavones, which are classified as phytoestrogens. Despite numerous proposed benefits, isoflavones are often classified as endocrine disruptors, based primarily on animal studies. However, there are ample human data regarding the health effects of isoflavones. We conducted a technical review, systematically searching Medline, EMBASE, and the Cochrane Library (from inception through January 2021). We included clinical studies, observational studies, and systematic reviews and meta-analyses (SRMA) that examined the relationship between soy and/or isoflavone intake and endocrine-related endpoints. 417 reports (229 observational studies, 157 clinical studies and 32 SRMAs) met our eligibility criteria. The available evidence indicates that isoflavone intake does not adversely affect thyroid function. Adverse effects are also not seen on breast or endometrial tissue or estrogen levels in women, or testosterone or estrogen levels, or sperm or semen parameters in men. Although menstrual cycle length may be slightly increased, ovulation is not prevented. Limited insight could be gained about possible impacts of in utero isoflavone exposure, but the existing data are reassuring. Adverse effects of isoflavone intake were not identified in children, but limited research has been conducted. After extensive review, the evidence does not support classifying isoflavones as endocrine disruptors.

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Changes in Dietary Intake in Pregnant Women from Periconception to Pregnancy in the Japan Environment and Children’s Study: A Nationwide Japanese Birth Cohort Study

Cited by 11 publications

References 33 publications

Distribution of 5-Methyltetrahydrofolate and Folic Acid Levels in Maternal and Cord Blood Serum: Longitudinal Evaluation of Japanese Pregnant Women

Distribution of 5-Methyltetrahydrofolate and Folic Acid Levels in Maternal and Cord Blood Serum: Longitudinal Evaluation of Japanese Pregnant Women

Community Pharmacist-Led Interventions to Improve Preconception and Pregnancy Health: A Systematic Review

Neither soyfoods nor isoflavones warrant classification as endocrine disruptors: a technical review of the observational and clinical data

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