Changes in depressive-like behaviors induced by spinal cord injury based on the hypothalamic-pituitary-adrenal axis and hippocampal neurogenesis

Liu, Changhong; Zhao, Binghai; Li, Wentao; Zhou, Xiaohua; Jin, Zhe; An, Lê Văn

doi:10.31083/j.jin2003067

Cited by 4 publications

(3 citation statements)

References 34 publications

(44 reference statements)

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“…Furthermore, Liu et al (2021) of the spinal cord, and found that changes in an immobility time (FST) and sucrose preference were strongly correlated with levels of serum corticosterone. In their SCI models, significant increased serum levels of corticosterone and decreased protein expression of hippocampal GR, BDNF, TrkB, and DCX (Doublecortin, a microtubule-associated protein of neuronal precursor cells)-positive cells after SCI were observed (Liu et al, 2021), suggesting that depressive-like behaviors after SCI is also regulated via the HPA-axis in which GR/BDNF interaction is involved.…”

Section: Relationship Between Bdnf Glucocorticoid Stress and Depressionmentioning

confidence: 98%

“…In their model, the upregulation of GR, and downregulation of PKA and BDNF, and decreased ratio of pCREB/CREB levels in several brain regions (anterior cingulate and insular cortex, amygdala, dorsal horn, and dorsal root ganglion) were also shown ( Sun et al, 2023 ). Furthermore, Liu et al (2021) investigated depressive-like behaviors after spinal cord injury (SCI) caused by severe mid-thoracic contusion of the spinal cord, and found that changes in an immobility time (FST) and sucrose preference were strongly correlated with levels of serum corticosterone. In their SCI models, significant increased serum levels of corticosterone and decreased protein expression of hippocampal GR, BDNF, TrkB, and DCX (Doublecortin, a microtubule-associated protein of neuronal precursor cells)-positive cells after SCI were observed ( Liu et al, 2021 ), suggesting that depressive-like behaviors after SCI is also regulated via the HPA-axis in which GR/BDNF interaction is involved.…”

Section: Relationship Between Bdnf Glucocorticoid Stress and Depressionmentioning

confidence: 99%

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Involvement of brain-derived neurotrophic factor signaling in the pathogenesis of stress-related brain diseases

Numakawa,

Kajihara

2023

Front. Mol. Neurosci.

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Neurotrophins including brain-derived neurotrophic factor, BDNF, have critical roles in neuronal differentiation, cell survival, and synaptic function in the peripheral and central nervous system. It is well known that a variety of intracellular signaling stimulated by TrkB, a high-affinity receptor for BDNF, is involved in the physiological and pathological neuronal aspects via affecting cell viability, synaptic function, neurogenesis, and cognitive function. As expected, an alteration of the BDNF/TrkB system is suspected to be one of the molecular mechanisms underlying cognitive decline in cognitive diseases and mental disorders. Recent evidence has also highlighted a possible link between the alteration of TrkB signaling and chronic stress. Furthermore, it has been demonstrated that downregulation of the BDNF/TrkB system and chronic stress have a role in the pathogenesis of Alzheimer’s disease (AD) and mental disorders. In this review, we introduce current evidence showing a close relationship between the BDNF/TrkB system and the development of cognition impairment in stress-related disorders, and the possible contribution of the upregulation of the BDNF/TrkB system in a therapeutic approach against these brain diseases.

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Section: Relationship Between Bdnf Glucocorticoid Stress and Depressionmentioning

confidence: 98%

Section: Relationship Between Bdnf Glucocorticoid Stress and Depressionmentioning

confidence: 99%

Involvement of brain-derived neurotrophic factor signaling in the pathogenesis of stress-related brain diseases

Numakawa,

Kajihara

2023

Front. Mol. Neurosci.

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“…SCIs slow intestinal peristalsis, lead to loss of automatic control of anal sphincter, and ability to voluntarily increase intra-abdominal pressure, resulting in neurogenic intestinal dysfunction, leading to constipation, abdominal distension, and other symptoms. [ 15 , 16 ] Approximately half of patients with SCIs have mild to severe intestinal dysfunction, and most of them occur in the early stage. [ 17 ] In the acute stage of SCI, patients can experience abdominal fullness and paralytic intestinal obstruction due to gastrointestinal peristalsis, which affects the movement of the diaphragm and causes respiratory distress in patients with quadriplegia.…”

Section: Introductionmentioning

confidence: 99%

Effects of comprehensive functional nursing on functional recovery and quality of life in patients with spinal cord injury

Ding,

Jiang,

et al. 2023

Medicine

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This study evaluated the effects of comprehensive functional nursing on functional recovery and quality of life in patients with spinal cord injuries (SCIs). A total of 214 patients with SCIs treated in our hospital from October 2019 to October 2021 were included in the retrospective analysis and divided into a general care group (n = 107) and a comprehensive care group (n = 107), based on the care that they received. Patients in the general care group received general functional nursing, whereas those in the comprehensive care group received a comprehensive functional nursing intervention. The Rivermead Mobility Index (RMI), Barthel Index (BI), and Berg Balance Score (BBS) were used to evaluate patient neurobehavioral ability before and after nursing. Changes in cardiopulmonary function indexes, left ventricular end-diastolic dimension (LVEDD), left ventricular end-systolic dimension (LVESD), vital capacity (VC), forced expiratory volume in 1 second (FEV1), FEV1/FVC, and maximal voluntary ventilation (MVV) were measured before and after nursing. The number of micturition, maximum micturition volume, bladder volume, residual urine volume, and lower urinary tract symptom (LUTS) score were recorded, and the improvement in bladder function were measured before and after nursing. The Hamilton Anxiety Scale (HAMA) and Beck Depression Inventory (BDI) scores were used to evaluate patients’ emotional state. After nursing, the RMI, BI, BBS score, FEV1, FEV1/FVC, MVV, maximum micturition volume, bladder volume, and SF-36 scores of the comprehensive care group were significantly higher than those of the general care group, and the LVEDD, LVESD, micturition time, residual urine volume, and LUTS, HAMA, and BDI scores of the comprehensive care group were significantly lower than those of the general care group. In patients with SCIs, comprehensive functional nursing can promote the recovery of neurocognition, bladder function, and cardiorespiratory function, and improve their quality of life. Comprehensive functional nursing is worthy of clinical application.

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Effect of Mucuna Pruriens Extract on Depression-Like Behavior Secondary to Mild Traumatic Brain Injury in Rats

Mata-Bermudez,

Trejo-Chávez,

Martínez-Vargas

et al. 2023

Preprint

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Changes in depressive-like behaviors induced by spinal cord injury based on the hypothalamic-pituitary-adrenal axis and hippocampal neurogenesis

Cited by 4 publications

References 34 publications

Involvement of brain-derived neurotrophic factor signaling in the pathogenesis of stress-related brain diseases

Involvement of brain-derived neurotrophic factor signaling in the pathogenesis of stress-related brain diseases

Effects of comprehensive functional nursing on functional recovery and quality of life in patients with spinal cord injury

Effect of Mucuna Pruriens Extract on Depression-Like Behavior Secondary to Mild Traumatic Brain Injury in Rats

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