Changes in dendritic spine density on layer 2/3 pyramidal cells within the cingulate cortex of late pregnant and postpartum rats

Salmaso, Natalina; Quinlan, Matthew G.; Brake, Wayne G.; Woodside, Barbara

doi:10.1016/j.yhbeh.2011.03.002

Cited by 17 publications

(11 citation statements)

References 46 publications

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“…; Pawluski and Galea ; Leuner and Gould ; Salmaso et al. ). Collectively, these data suggest that the effects of offspring on parenting‐induced hippocampal plasticity are similar between sexes.…”

Section: Discussionmentioning

confidence: 98%

Fatherhood contributes to increased hippocampal spine density and anxiety regulation in California mice

et al. 2015

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IntroductionParenting alters the hippocampus, an area of the brain that undergoes significant experience‐induced plasticity and contributes to emotional regulation. While the relationship between maternal care and hippocampal neuroplasticity has been characterized, the extent to which fatherhood alters the structure and function of the hippocampus is far less understood.MethodsHere, we investigated to what extent fatherhood altered anxiety regulation and dendritic morphology of the hippocampus using the highly paternal California mouse (Peromyscus californicus).ResultsFathers spent significantly more time on the open arms of the elevated plus maze, compared to non‐fathers. Total distance traveled in the EPM was not changed by paternal experience, which suggests that the increased time spent on the open arms of the maze indicates decreased anxiety‐like behavior. Fatherhood also increased dendritic spine density of granule cells in the dentate gyrus and basal dendrites of pyramidal cells in area CA1 of the hippocampus.ConclusionsThese findings parallel those observed in maternal rodents, suggesting that the hippocampus of fathers and mothers respond similarly to offspring.

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Section: Discussionmentioning

confidence: 98%

Fatherhood contributes to increased hippocampal spine density and anxiety regulation in California mice

et al. 2015

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“…Another hormone that raises its levels in the post‐pregnancy stage is prolactin, whose receptors are located in the PFC and the hippocampus, among others (Bakowska & Morrell, ; Cabrera‐Reyes, Vergara‐Castañeda, Rivero‐Segura, & Cerbón, ). Recent studies have also suggested that this hormone may improve cognition and play a neuroprotective role, showing an increase in the density of dendritic spines in the PFC and CA1 of the hippocampus during lactation (Carretero et al, ; Chen et al, ; Salmaso, Quinlan, Brake, & Woodside, ). However, to know if this hormone participates in the changes described in the present work, it is necessary to study only the effect of pregnancy without lactation to resolve this question.…”

Section: Discussionmentioning

confidence: 99%

Pregnancies alters spine number in cortical and subcortical limbic brain regions of old rats

Flores-Vivaldo

Camacho-Ábrego

Picazo

et al. 2019

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Pregnancy is a complex process, involving a number of hormones and trophic factors, many of which are formed in the placenta. Several of these trophic factors have an effect at the neuronal level, such as BDNF. Consequently, recent reports have shown that exposure to these hormones (estrogen and progesterone) and trophic factors such as BDNF exert a neuroprotective effect. Here, we study the effect of the number of pregnancies on dendritic morphology of aged female rats (18 months of age). Rats of the 18‐month‐old Sprague Dawley strain with zero, one, two, and three gestations were evaluated for locomotor activity, and Golgi–Cox stain was performed to evaluate the dendritic morphology parameters, the number of dendritic spines, total dendritic length, and branching order number. Adult nulliparous rats (3 months of age) were used as another control group. Adult nulliparous and aging rats with two pregnancies showed an increase in locomotor activity. Adult nulliparous showed an increase in the dendritic spine number compared to old nulliparous rats in both layers of the PFC, the DG, and NAcc. Old rats with two and three pregnancies also showed an increase in the number of dendritic spines compared to old nulliparous rats in layers 3 and 5 of the PFC and in the CA1. Aging animals with one pregnancy also showed an increase in dendritic length compared to old nulliparous rats in the CA1. Our results clearly suggest that two and three pregnancies increase the dendritic spines number in the PFC and CA1 of aged female rats.

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“…In agreement with our results, Salmaso et al () have suggested that the postpartum stage is a critical period associated with an increase in the dendritic spine density (3 hr after postpartum) in the PFC (Cg2) and hippocampus (CA1) and dendritic arbor (in the lactation period) at the level of the PFC (Cg2) in the rat. Additionally, the same group has demonstrated changes in astrocyte proteins, glial fibrillary acidic protein (GFAP) and basic fibroblast growth factor (bFGF) in the PFC (Cg2) in female rats in the postpartum stage (Salmaso et al, , ; Salmaso & Woodside, ) and suggested that changes in the expression of these astrocyte proteins may work with the rearrangement of the dendritic morphology (Salmaso et al, ). In addition, Kinsley et al (), also reported an increase in the number of dendritic spines in the CA1 region of the hippocampus in the late pregnancy and lactation period.…”

Section: Discussionmentioning

confidence: 99%

Pregnancy improves cognitive deficit and neuronal morphology atrophy in the prefrontal cortex and hippocampus of aging spontaneously hypertensive rats

Cabrera-Pedraza

Gómez-Villalobos

Cruz

et al. 2017

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It is well known that the survival is higher in women compared to men and women have a better survival prognosis than men in some pathologies such as vascular dementia (VD). Our previous reports showed that the spontaneously hypertensive (SH) rat, an animal model of VD, exhibited dendritic atrophy of pyramidal neurons of the dorsal hippocampus (DH) and the prefrontal cortex (PFC) at 8 months of age. Cerebrolysin (CBL), a neurotrophic peptide mixture, reduces dendritic atrophy and improves the memory process in aged rats. Here, we investigated whether one pregnancy or/and CBL was capable of improving cognitive behavior and neuronal alterations in old female SH rats. Diastolic and systolic blood pressure were assessed before pregnancy (3 months old) and CBL administration (6 months old), and after CBL administration (12 months old). Immediately after of 6 months of CBL treatment, locomotor activity in novel environments and memory and learning by the Morris Water Maze test were evaluated. By the Golgi-Cox staining method, dendritic parameters were assessed in PFC and DH. Our results suggest that rats with one pregnancy showed better memory with an enhancement in dendritic length and dendritic spine density in the aforementioned regions.

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Changes in dendritic spine density on layer 2/3 pyramidal cells within the cingulate cortex of late pregnant and postpartum rats

Cited by 17 publications

References 46 publications

Fatherhood contributes to increased hippocampal spine density and anxiety regulation in California mice

Fatherhood contributes to increased hippocampal spine density and anxiety regulation in California mice

Pregnancies alters spine number in cortical and subcortical limbic brain regions of old rats

Pregnancy improves cognitive deficit and neuronal morphology atrophy in the prefrontal cortex and hippocampus of aging spontaneously hypertensive rats

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