Changes in default mode network connectivity in different glucose metabolism status and diabetes duration

Abstract

Aims/hypothesesIt is now generally accepted that diabetes increases the risk for cognitive impairment, but the precise mechanisms are poorly understood. In recent years, resting-state functional magnetic resonance imaging (rs-fMRI) is increasingly used to investigate the neural basis of cognitive dysfunction in type 2 diabetes (T2D) patients. Alterations in brain functional connectivity may underlie diabetes-related cognitive dysfunction and brain damage. The aim of this study was to investigate the changes in default mode network (DMN) connectivity in different glucose metabolism status and diabetes duration.MethodsWe used a seed-based fMRI analysis to investigate positive and negative DMN connectivity in four groups (39 subjects with normal glucose metabolism [NGM], 23 subjects with impaired glucose metabolism [IGM; i.e., prediabetes], 59 T2D patients with a diabetes duration of <10 years, and 24 T2D patients with a diabetes duration of ≥10 years).ResultsNegative DMN connectivity increased and then regressed with deteriorating glucose metabolism status and extending diabetes duration. DMN connectivity showed a significant correlation with diabetes duration.Conclusion/interpretationThis study suggests that DMN connectivity may exhibit distinct patterns in different glucose metabolism status and diabetes duration, providing some potential neuroimaging evidence for early diagnosis and further understanding of the pathophysiological mechanisms of diabetic brain damage.

Abnormal Cingulum Bundle Induced by Type 2 Diabetes Mellitus: A Diffusion Tensor Tractography Study

“…The disruption of CB in T2DM is thus not unexpected, which might reflect an overlapping pattern during the process of cognitive decline. Besides, we and several other studies have previously reported DMN disconnection in T2DM patients, especially in its posterior components (Cui et al, 2015;Ishibashi et al, 2018;Liu et al, 2019). Given that CB is the anatomical basis for DMN (van den Heuvel et al, 2008), the present CB abnormalities not only are supported by the previous functional results but also extend fMRI studies by adding anatomical evidence.…”

Dynamic brain-body coupling of breath-by-breath O2-CO2 exchange ratio with resting state cerebral hemodynamic fluctuations

“…coupling in DMN found in our study is consistent with the findings in previous studies that CBF and DMN connectivity were altered in individuals with disrupted systemic metabolism [57][58][59][60][61][62][63][64].…”

Dynamic Brain-Body Coupling of Breath-by-Breath O2-CO2Exchange Ratio with Resting State Cerebral Hemodynamic Fluctuations

“…bER which showed the strongest correlation with CHF is therefore expected to interact more with DMN. The bER-DMN coupling is consistent with findings in previous studies that CBF and DMN connectivity were altered in individuals with disrupted systemic metabolism (Chen et al, 2017;Ishibashi et al, 2018;Ishibashi et al, 2016;Li et al, 2017;Liu et al, 2017a;Liu et al, 2019;Lockwood et al, 1991;Qi et al, 2014).…”