Changes in daily serum corticosterone values in maturing male and female rats

Ramaley, Judith A.

doi:10.1016/0039-128x(72)90069-4

Cited by 50 publications

(25 citation statements)

References 11 publications

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“…The sensitivity of the assay was such that values down to 4.0 µg/ JOO ml could be routinely measured and at times values as low as 2.5 µg/ 100 ml could be detected. This compares well with values in the literature (85,157) and is well below the background fluorescence found in place of adrenalectomized animals in other studies (6.0 ! .07 µg/100 ml) 52 and in our own (6.5 ± 0.9 µg/100 ml).…”

Section: Detection Of Ovulation and Evaluation Of Cycle Stagesupporting

confidence: 91%

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Adrenal Involvement in Determining the Time of Onset of Puberty in the Rat1

Gorski

Lawton

1973

Endocrinology

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Section: Detection Of Ovulation and Evaluation Of Cycle Stagesupporting

confidence: 91%

“…Although the plasma levels of corticosterone appear to remain the same during the days and at the times studied It is possible that Rhythmic adrenal secretions have begun by day 20 (Study IV) and the system is already capable of responding to stress (6,157).…”

Section: Commentsmentioning

confidence: 97%

Adrenal Involvement in Determining the Time of Onset of Puberty in the Rat1

Gorski

Lawton

1973

Endocrinology

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“…For example, the observed hypersensitivity to stress in pubertal mice is in agreement with the previous findings in humans (Allen and Matthews, 1997) and in rodents (Walker et al, 1995;Hascoet et al, 1999). In addition, sex-dependent stress regulation was observed mainly in adult mice and not in pubertal mice, indicating that certain stress regulation systems mature during and/or after puberty in a sex-dependent manner (Ramaley, 1972;Gabriel et al, 1992;Spinedi et al, 1997).…”

Section: Anatomical Correlates Of Stress and Learning Impairments In supporting

confidence: 80%

Postpubertal Sex Differentiation of Forebrain Structures and Functions Depend on Transforming Growth Factor-α

Koshibu¹,

Ahrens²,

Levitt³

2005

J. Neurosci.

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Sex-and age-associated deficits in brain structure and behavior are reported in a number of neuropsychiatric disorders. Although genetic and environmental factors are thought to contribute to the pathogenesis, there are only few examples in clinical or experimental systems that have identified specific causes. Here, we report that transforming growth factor-␣ (TGF␣) may regulate sex-and age-dependent development of forebrain structures and associated neural functions after puberty. Waved-1 (Wa-1) mice inherit an autosomal recessive, spontaneous mutation that results in a postnatal reduction in TGF␣ gene expression. The assessment of forebrain structures using a three-dimensional magnetic resonance microscopy indicated ventricular enlargement and striatal reduction in both male and female Wa-1 adult mice, with Wa-1 males exhibiting a more severe phenotype. In contrast, the hippocampal volume was reduced only in adult Wa-1 males. Similarly, behavioral analyses showed impaired auditory and contextual fear learning in adult Wa-1 males only, whereas abnormal stress response was expressed by both male and female adult Wa-1 mice. Interestingly, all behavioral deficits were absent before full sexual maturation, despite some slight forebrain structural abnormalities. These results suggest that TGF␣ may regulate postpubertal, sex differentiation in ventricular and periventricular anatomy and associated behavior, affecting predominantly males. In particular, the adult male-specific reduction in hippocampal volume may reflect an age-and sex-specific regulation of stress homeostasis and fear learning. Furthermore, a lack of a behavioral phenotype, despite anatomical alterations in peripubertal Wa-1 mice, suggests that analysis of certain neuroanatomical features at puberty may predict neurobehavioral deficits in adulthood.

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“…In recent work using mice, however, adolescents were observed to have lower corticosterone levels than adults following the mild stress of saline injection [312]. Gender differences in the corticosterone response to stress begin to emerge late in adolescence, with elevated levels in female rats when compared with males as well as prepubescent females [91,184,451].…”

Section: Hormonal Response To Stressors In Adolescencementioning

confidence: 99%

The adolescent brain and age-related behavioral manifestations

Spear

2000

Neuroscience & Biobehavioral Reviews

4,636

110

4,301

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To successfully negotiate the developmental transition between youth and adulthood, adolescents must maneuver this often stressful period while acquiring skills necessary for independence. Certain behavioral features, including age-related increases in social behavior and risk-taking/novelty-seeking, are common among adolescents of diverse mammalian species and may aid in this process. Reduced positive incentive values from stimuli may lead adolescents to pursue new appetitive reinforcers through drug use and other risk-taking behaviors, with their relative insensitivity to drugs supporting comparatively greater per occasion use. Pubertal increases in gonadal hormones are a hallmark of adolescence, although there is little evidence for a simple association of these hormones with behavioral change during adolescence. Prominent developmental transformations are seen in prefrontal cortex and limbic brain regions of adolescents across a variety of species, alterations that include an apparent shift in the balance between mesocortical and mesolimbic dopamine systems. Developmental changes in these stressor-sensitive regions, which are critical for attributing incentive salience to drugs and other stimuli, likely contribute to the unique characteristics of adolescence. ᭧

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Changes in daily serum corticosterone values in maturing male and female rats

Cited by 50 publications

References 11 publications

Adrenal Involvement in Determining the Time of Onset of Puberty in the Rat1

Adrenal Involvement in Determining the Time of Onset of Puberty in the Rat1

Postpubertal Sex Differentiation of Forebrain Structures and Functions Depend on Transforming Growth Factor-α

The adolescent brain and age-related behavioral manifestations

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