Changes in D‐dimer concentration after soft tissue and orthopedic surgery in dogs

Shipov, Anna; Milgram, Joshua; Shalev, Nitzan; Aroch, Itamar; Segev, Gil

doi:10.1111/vsu.12779

Cited by 1 publication

(2 citation statements)

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“…, Shipov et al . ). Increased FDPs/D‐dimers are also associated with pathological processes such as disseminated intravascular coagulation (DIC) or thromboembolic disease in which a regulated hyperfibrinolysis represents an initial protective mechanism (Stokol et al .…”

Section: Laboratory Assessment Of Fibrinolysismentioning

confidence: 97%

“…Elevated FDPs and D-dimers are supportive of, but not specific to, hyperfibrinolysis. Mildly elevated FDPs/D-dimers are documented during normal post-operative healing in dogs (Sobiech et al 2011, Moldal et al 2012, Shipov et al 2018. Increased FDPs/D-dimers are also associated with pathological processes such as disseminated intravascular coagulation (DIC) or thromboembolic disease in which a regulated hyperfibrinolysis represents an initial protective mechanism (Stokol et al 1999, Nelson & Andreasen 2003, Stokol 2003, Machida et al 2010).…”

Section: Laboratory Assessment Of Fibrinolysismentioning

confidence: 99%

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A review of hyperfibrinolysis in cats and dogs

Birkbeck

Humm

Cortellini

2019

J of Small Animal Practice

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The fibrinolytic system is activated concurrently with coagulation; it regulates haemostasis and prevents thrombosis by restricting clot formation to the area of vascular injury and dismantling the clot as healing occurs. Dysregulation of the fibrinolytic system, which results in hyperfibrinolysis, may manifest as clinically important haemorrhage. Hyperfibrinolysis occurs in cats and dogs secondary to a variety of congenital and acquired disorders. Acquired disorders associated with hyperfibrinolysis, such as trauma, cavitary effusions, liver disease and Angiostrongylus vasorum infection, are commonly encountered in primary care practice. In addition, delayed haemorrhage reported in greyhounds following trauma and routine surgical procedures has been attributed to a hyperfibrinolytic disorder, although this has yet to be characterised. The diagnosis of hyperfibrinolysis is challenging and, until recently, has relied on techniques that are not readily available outside referral hospitals. With the recent development of point‐of‐care viscoelastic techniques, assessment of fibrinolysis is now possible in referral practice. This will provide the opportunity to target haemorrhage due to hyperfibrinolysis with antifibrinolytic drugs and thereby reduce associated morbidity and mortality. The fibrinolytic system and the conditions associated with increased fibrinolytic activity in cats and dogs are the focus of this review article. In addition, laboratory and point‐of‐care techniques for assessing hyperfibrinolysis and antifibrinolytic treatment for patients with haemorrhage are reviewed.

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Section: Laboratory Assessment Of Fibrinolysismentioning

confidence: 97%