Changes in cytomegalovirus seroprevalence in pregnant Japanese women—A 10-year single center study

Taniguchi, Kosuke; Watanabe, Noriyoshi; Sato, Anna; Jwa, Seung Chik; Suzuki, Tomo; Yamanobe, Yuji; Sago, Haruhiko; Kozuka, Kazuto

doi:10.1016/j.jcv.2013.12.013

Cited by 37 publications

(20 citation statements)

References 8 publications

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“…The seroprevalence of CMV increases with age, depending on geographic area and socioeconomic status. CMV seroprevalence has been decreasing recently in Japan (4). In this study, the seropositive rate for CMV decreased significantly, from 76z in 2001-2002 to 67z in 2013, similar to previous reports (4,5).…”

Section: Discussionsupporting

confidence: 90%

“…CMV seroprevalence has been decreasing recently in Japan (4). In this study, the seropositive rate for CMV decreased significantly, from 76z in 2001-2002 to 67z in 2013, similar to previous reports (4,5). Though significant congenital morbidity is observed following both primary and non-primary maternal infection, the presence of maternal antibodies to CMV is the most important protective factor against congenital CMV infection (3).…”

Section: Discussionsupporting

confidence: 86%

“…Pre-existing maternal antibodies to CMV are the most important protective factor against congenital CMV infection, and primary CMV infection is more likely than non-primary infection to cause symptoms at birth and long-term disability (3). However, the seroprevalence among pregnant women ranges between 65z and 87z, and has been decreasing recently in Japan (4,5).…”

Section: Introductionmentioning

confidence: 99%

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Time-Series Analysis Comparing the Prevalence of Antibodies against Nine Viral Species Found in Umbilical Cord Blood in Japan

et al. 2016

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SUMMARY:In this study, we investigated the prevalence of antibodies against 9 viral species found in umbilical cord blood from 561 neonates in 2013. Serum IgG antibodies against the following viruses were measured: herpes simplex virus (HSV), varicella-zoster virus (VZV), Epstein-Barr virus (EBV), cytomegalovirus (CMV), human herpesvirus 6 (HHV-6), measles virus (MV), rubella virus (RV), mumps virus (MuV), and human parvovirus B19 (HPV B19). A survey questionnaire regarding past medical history and maternal immunization status for the vaccine-preventable diseases of varicella, measles, rubella, and mumps was simultaneously administered. The results were compared with previous data collected in 2001-2002 from 378 umbilical cord blood samples. Viral seroprevalence data were: HSV, 54z; VZV, 96z; EBV, 96z; CMV, 67z; HHV-6, 100z; MV, 95z; RV, 94z; MuV, 64z; and HPV B19, 55z. The seroprevalence of CMV, MV, and MuV were significantly lower in 2013 than in 2001 -2002 MV, 98z; MuV, 93z). Compared with the 2001-2002 data, the mean IgG antibody values of the 4 vaccine-preventable diseases were significantly lower, and vaccination coverage for those diseases among mothers was significantly higher. Thus, attention should be paid to antibody levels in women of childbearing age in the future.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

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Time-Series Analysis Comparing the Prevalence of Antibodies against Nine Viral Species Found in Umbilical Cord Blood in Japan

et al. 2016

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“…A country’s socioeconomic development correlates inversely with CMV seroprevalence, with the highest rates observed in developing countries throughout Africa and Asia [11]. In Japan, an interesting study has recently assessed CMV seroprevalence in pregnant women [12]. This cross-sectional study included pregnant Japanese women who gave birth between 2003 and 2012 at the hospital (n = 15,616).…”

Section: Introductionmentioning

confidence: 99%

Cytomegalovirus Colitis, Cytomegalovirus Hepatitis and Systemic Cytomegalovirus Infection: Common Features and Differences

Nakase

Herfarth

2016

Inflamm Intest Dis

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Cytomegalovirus (CMV) is a ubiquitous human herpes virus, which, after often asymptomatic primary infection, establishes a lifelong latent infection that can periodically be reactivated in both immunocompetent and immunosuppressed carriers. Whereas the diagnostic approach in case of a suspicion of CMV reactivation is well defined, the indication for antiviral therapy can often only be made in the context of an extent of organ involvement, the immune status, and comorbidities of the patient. This article reviews the epidemiology, diagnosis, and therapy of CMV reactivation with a focus on inflammatory bowel diseases and potentially different diagnostic and therapeutic approaches in Asia and the Western world.

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“…For instance: two studies performed in Japan reported CMV seroprevalences of 66% (41) and 87.3% (42) . Such disparity shows how complex CMV epidemiology can be.…”

Section: Epidemiologymentioning

confidence: 99%

Cytomegalovirus Infection in Pregnancy

&NA;

2013

Postgraduate Obstetrics & Gynecology

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Congenital cytomegalovirus (CMV) infection is the leading cause of infectious congenital defects and disabilities. Its transmission can occur in primary and non-primary infections; however the transmission rate is considerably higher in primary infections. The diagnosis of congenital infection is complex, and there is a discussion concerning serological evaluation during pregnancy. This article aims to review the literature concerning CMV infection, its diagnosis and epidemiology.

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Changes in cytomegalovirus seroprevalence in pregnant Japanese women—A 10-year single center study

Cited by 37 publications

References 8 publications

Time-Series Analysis Comparing the Prevalence of Antibodies against Nine Viral Species Found in Umbilical Cord Blood in Japan

Time-Series Analysis Comparing the Prevalence of Antibodies against Nine Viral Species Found in Umbilical Cord Blood in Japan

Cytomegalovirus Colitis, Cytomegalovirus Hepatitis and Systemic Cytomegalovirus Infection: Common Features and Differences

Cytomegalovirus Infection in Pregnancy

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