Abstract:Aim
This study was designed to evaluate CYP450 enzyme activity in liver transplant (OLTx) patients.
Methods
Thirty‐nine stable OLTx patients (mean age 51 yrs) studied on 69 occasions were given an oral 5‐drug Pittsburgh cocktail to assess CYPs 1A2, 2C19, 2D6, 2E1 and 3A. Concentrations of drugs/metabolites were determined by HPLC for phenotype analysis. Seven elderly and 14 young healthy subjects (mean ages 77 and 21 yrs) were studied as controls.
Results
Within 30 days postoperatively, 2E1 activity was higher… Show more
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