Changes in Cyclic Guanosine Monophosphate Channel of 661w Cells In vitro with Excessive Light Time
Yahan Zhang,
Rui Yin,
Xin Liu
Abstract:Purpose: To determine the response time and protective mechanism of the cyclic guanosine monophosphate (cGMP) channel in 661w cells. Methods: 661w cells were exposed to 4500Lux visible light for three and four days at the following exposure time periods per day: 20, 30, 60, 90, 120, and 180. Cells were incubated for the rest of the time without any other treatment. Cell activity and cell death rates were measured with Hoechst/PI (diphenylmethane/propidium iodide) staining. Western Blot was used to detect the l… Show more
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