Changes in Corticospinal Excitability and Motor Control During Cerebellar Transcranial Direct Current Stimulation in Healthy Individuals

Takano, Keita; Katagiri, Natsuki; Sato, Takatsugu; Jin, Masafumi; Koseki, Tadaki; Kudo, Daisuke; Yoshida, Kaito; Tanabe, Shigeo; Tsujikawa, Masahiro; Kondo, Kunitsugu; Yamaguchi, Tomohiko

doi:10.1007/s12311-022-01469-2

Cited by 10 publications

(5 citation statements)

References 60 publications

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“…Second, the cortical excitability of the M1 was not measured in this study, thus we cannot confirm whether acb-tDCS could induce changes in corticospinal tract excitability. However, as Takano et al have previously demonstrated that acb-tDCS elicits a decrease in corticospinal excitability after 13 min of stimulation [50], we could infer that our protocol (20 min of acb-tDCS) was sufficient to induce changes in corticospinal excitability. Third, our experiment did not include behavioral measurements, hindering us from investigating whether the changes in HbO on the M1 cortices are related to behavioral outcomes.…”

Section: Discussionmentioning

confidence: 70%

Investigation of neuromodulatory effect of anodal cerebellar transcranial direct current stimulation on the primary motor cortex using functional near-infrared spectroscopy

Shoaib

Chang

Lee

et al. 2022

Preprint

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Background: Cerebellar brain inhibition (CBI), a neural connection between the cerebellum and primary motor cortex (M1), has been researched as a target pathway for neuromodulation to improve clinical outcomes in various neurological diseases. However, conflicting results of anodal cerebellar transcranial direct current stimulation (acb-tDCS) on M1 excitability indicate that additional investigation is required to examine its precise effect. Objective/Hypothesis: This study aimed to gather evidence of the neuromodulatory effect of acb-tDCS on the M1 using functional near-infrared spectroscopy (fNIRS). Methods: Sixteen healthy participants were included in this cross-over study. Participants received real and sham acb-tDCS in a random order, with a minimum one-week washout period between them. The anode and cathode were placed on the right cerebellum and the right buccinator muscle, respectively. Stimulation lasted 20 min at an intensity of 2 mA, and fNIRS data were recorded for 42 min (including a 4 min baseline before stimulation and an 18 min post-stimulation duration) using eight channels attached bilaterally on the M1. Results: acb-tDCS induced a significant decrease in oxyhemoglobin (HbO) concentration (inhibitory effect) in the left (contralateral) M1, whereas it induced a significant increase in HbO concentration (excitatory effect) in the right (ipsilateral) M1 compared to sham tDCS during (p < 0.05) and after stimulation (p < 0.01) in a group level analysis. At the individual level, variations in the response to acb-tDCS were observed. Conclusion: Our findings demonstrate the neuromodulatory effects of acb-tDCS on the bilateral M1 in terms of neuronal hemodynamics.

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Section: Discussionmentioning

confidence: 70%

Investigation of neuromodulatory effect of anodal cerebellar transcranial direct current stimulation on the primary motor cortex using functional near-infrared spectroscopy

Shoaib

Chang

Lee

et al. 2022

Preprint

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“…Then, the study task structure prevented a control experiment to isolate the cerebellar-specific role in internal model formation using the same paradigm. On the one hand, delivering ctDCS only during familiarization would lead to carry-over effects ( Takano et al ., 2022 ), challenging the differentiation between online and offline effects. On the other hand, extending the time between phases could impact memory maintenance of action-cue associations.…”

Section: Discussionmentioning

confidence: 99%

Excitatory cerebellar transcranial direct current stimulation boosts the leverage of prior knowledge for predicting actions

Oldrati,

Butti,

Ferrari

et al. 2024

Social Cognitive and Affective Neuroscience

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The cerebellum causally supports social processing by generating internal models of social events based on statistical learning of behavioral regularities. However, whether the cerebellum is only involved in forming or also in using internal models for the prediction of forthcoming actions is still unclear. We used cerebellar transcranial Direct Current Stimulation (ctDCS) to modulate the performance of healthy adults in using previously learned expectations in an action prediction task. In a first learning phase of this task, participants were exposed to different levels of associations between specific actions and contextual elements, to induce the formation of either strongly or moderately informative expectations. In a following testing phase, which assessed the use of these expectations for predicting ambiguous (i.e. temporally occluded) actions, we delivered ctDCS. Results showed that anodic, compared to sham, ctDCS boosted the prediction of actions embedded in moderately, but not strongly, informative contexts. Since ctDCS was delivered during the testing phase, that is after expectations were established, our findings suggest that the cerebellum is causally involved in using internal models (and not just in generating them). This encourages the exploration of the clinical effects of ctDCS to compensate poor use of predictive internal models for social perception.

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“…Computational modelling studies have suggested that weak exogenous electric currents at an intensity of 2 mA can penetrate the outer layers of the cerebellar cortex. Experimental research findings have demonstrated that cerebellar tDCS can elicit neurophysiological alterations in cerebellar-brain interactions [86] and has the potential to impact gait adaptation, motor learning, and cognition in healthy individuals [106][107][108][109]. For instance, cerebellar tDCS has been found to interfere with motor cortex synaptic plasticity during PAS involving the median nerve and motor cortex, suggesting the cerebellum's role in synchronizing sensory input and motor output [110].…”

Section: Transcranial Direct Current Stimulation (Tdcs)mentioning

confidence: 99%

Cerebellar Non-Invasive Brain Stimulation: A Frontier in Chronic Pain Therapy

Sveva,

Cruciani,

Mancuso

et al. 2024

JPM

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Chronic pain poses a widespread and distressing challenge; it can be resistant to conventional therapies, often having significant side effects. Non-invasive brain stimulation (NIBS) techniques offer promising avenues for the safe and swift modulation of brain excitability. NIBS approaches for chronic pain management targeting the primary motor area have yielded variable outcomes. Recently, the cerebellum has emerged as a pivotal hub in human pain processing; however, the clinical application of cerebellar NIBS in chronic pain treatment remains limited. This review delineates the cerebellum’s role in pain modulation, recent advancements in NIBS for cerebellar activity modulation, and novel biomarkers for assessing cerebellar function in humans. Despite notable progress in NIBS techniques and cerebellar activity assessment, studies targeting cerebellar NIBS for chronic pain treatment are limited in number. Nevertheless, positive outcomes in pain alleviation have been reported with cerebellar anodal transcranial direct current stimulation. Our review underscores the potential for further integration between cerebellar NIBS and non-invasive assessments of cerebellar function to advance chronic pain treatment strategies.

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Changes in Corticospinal Excitability and Motor Control During Cerebellar Transcranial Direct Current Stimulation in Healthy Individuals

Cited by 10 publications

References 60 publications

Investigation of neuromodulatory effect of anodal cerebellar transcranial direct current stimulation on the primary motor cortex using functional near-infrared spectroscopy

Investigation of neuromodulatory effect of anodal cerebellar transcranial direct current stimulation on the primary motor cortex using functional near-infrared spectroscopy

Excitatory cerebellar transcranial direct current stimulation boosts the leverage of prior knowledge for predicting actions

Cerebellar Non-Invasive Brain Stimulation: A Frontier in Chronic Pain Therapy

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