Changes in cortical thickness of the clavicle and serum bone gamma-carboxyglutamic acid-containing protein in the elderly in an island community in western Japan.

A total of 26 subjects, 13 premenopausal and 13 postmenopausal women, aged between 46 and 52 were examined for their cortical thickness of the clavicle, serum bone gamma-carboxyglutamic acid-containing protein (BGP, osteocalcin), serum alkaline phosphatase, serum calcium, serum inorganic phosphate, urinary calcium/creatinine and urinary inorganic phosphate/creatinine. Serum BGP was significantly higher in postmenopausal than in premenopausal women. Serum alkaline phosphatase also tended to elevate in postmenopausal women, while there were no significant differences in cortical thickness of the clavicle, serum calcium, serum inorganic phosphate, urinary calcium/creatinine and urinary inorganic phosphate/creatinine between the two. Considering that both serum BGP and serum alkaline phosphatase are markers of bone formation, these findings indicate that menopause firstly accelerates bone turnover preceding age related bone loss. Key wordsmenopause; serum bone gamma carboxyglutamic acid-containing protein; bone turnover JBMM Vol. 7, No. 1 level of serum BGP is a marker for assessing the progress of bone loss in each woman.

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Elevated levels of serum bone gamma-carboxyglutamic acid-containing protein in postmenopausal women

Aoyagi

Moji

Takemoto

1989

J Bone Miner Metab

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Age-at-death estimation based on radiological and image analysis methods in clavicle in a current Spanish population

2014

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Age-at-death estimation in adult individuals is one of the most challenging issues in forensic anthropology, namely, due to the large age intervals provided by the current methods, which demand the development of more reliable investigations. The clavicle has been studied as an age-at-death indicator in many researches for its accessibility, low biomechanical implication in locomotion and accuracy to predict age at death when other age indicators are not available. The present study was developed on a sample of 332 clavicles from adult individuals of known sex and age from the current Spanish population. They were x-rayed and digitalized, in a standardized way, using a Sedecal X-ray generator, model SHF 415. Three indices were calculated at the mid-diaphysis point (anterior index, posterior index, and total index) which relate the cortical thickness and the total clavicle thickness to age at death. The average grey level was also calculated in a 0.5-cm(2) area of the sternal and acromial ends (sternal grey average, acromial grey average), using Image J software. The data were subjected to a statistical analysis, using SPSS, version 15.0. The results show that average grey level has a weaker correlation with age than the variables which are based on the cortical thickness. On the other hand, the regression equations, which were calculated combining all the variables, provided smaller age-at-death intervals, demonstrating the usefulness of this method for adult age-at-death estimation in forensic anthropology.

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Changes in cortical thickness of the clavicle and serum bone gamma-carboxyglutamic acid-containing protein in the elderly in an island community in western Japan.

Cited by 2 publications

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Elevated levels of serum bone gamma-carboxyglutamic acid-containing protein in postmenopausal women

Elevated levels of serum bone gamma-carboxyglutamic acid-containing protein in postmenopausal women

Age-at-death estimation based on radiological and image analysis methods in clavicle in a current Spanish population

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