Changes in cortical thickness across the lifespan in major depressive disorder

Truong, Wanda; Minuzzi, Luciano; Soares, Cláudio N.; Frey, Benício N.; Evans, Alan C.; MacQueen, Glenda; Hall, Geoffrey B.

doi:10.1016/j.pscychresns.2013.09.003

Cited by 61 publications

(55 citation statements)

References 47 publications

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“…Cortical surface area and thickness are also genetically and phenotypically independent (18), but the contribution of cortical thickness toward structural brain abnormalities in mood disorders remains largely unknown. A small number of studies have, however, reported cortical thickness abnormalities in MDD and BD patients in the frontal lobe (19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31) and superior temporal gyrus (22,23,29,31). Moreover, thickness reductions in the inferior and middle temporal (31), parahippocampal (22), and fusiform gyrus (21,23) have been found in BD.…”

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confidence: 99%

Cortical Thickness in Individuals at High Familial Risk of Mood Disorders as They Develop Major Depressive Disorder

Papmeyer

Giles

Sussmann

et al. 2015

Biological Psychiatry

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confidence: 99%

Cortical Thickness in Individuals at High Familial Risk of Mood Disorders as They Develop Major Depressive Disorder

Papmeyer

Giles

Sussmann

et al. 2015

Biological Psychiatry

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“…A handful of studies have assessed spatial patterns of cortical thickness in MDD. Interestingly, the regional patterns of cortical thinning in MDD do not perfectly reflect what would be expected from the neuroimaging literature (i.e., cortical thinning is not confined to cognitive and emotive centers; fronto-cortico-limbic structures) [1].…”

Section: Introductionmentioning

confidence: 60%

“…Exploratory rmANOVAs (group as between-and hemisphere as withinsubject factors, HAMD 17 as the covariate) yielded no significant results, apart from a weak trend for a main effect of group (F [1,28] Finally, Chi-square tests revealed no significant difference in the proportion of the pediatric versus adult MDD onset individuals in either the abuse or nonabuse groups. MANCOVAs (HAMD 17 scores and age as covariates) were carried out with the two MDD onset (adult and pediatric) and two childhood trauma groups (abuse and nonabuse) as the independent variables on cortical thickness measures.…”

Section: Two Group Analyses (Mdd Groups: Childhood Abuse Group and Nomentioning

confidence: 84%

“…A main effect of group (neglect, abuse) was found on HAMD 17 scores (F[1,29] = 4.21, = .049), with higher scores in the abuse group. The abuse group also had higher CTQ Total (F[1,29] = 27.38, < .001) and, expectedly, abuse scores (F [1,29] = 42.04, < .001) than the nonabuse group ( Table 2).…”

Section: Two Group Analyses (Mdd Groups: Childhood Abuse Group and Nomentioning

confidence: 95%

“…Exploratory rmANOVAs (HAMD 17 scores and age as covariates; hemisphere as with-and groups as between-subject factors; significance was set at < .01) yielded a trend for an onset group × childhood trauma group interaction for superior temporal cortex thickness (F[1,25] = 5.98, = .022), with pairwise comparisons indicating a trend for a difference in cortical thickness between the pediatric ( = 8; 2.59 ± .14) and adult ( = 8; 2.77 ± .14) MDD onset groups with childhood abuse ( = .02). For frontal pole thickness, an onset group × childhood trauma group × hemisphere interaction trend existed (F [1,25] …”

Section: Two Group Analyses (Mdd Groups: Childhood Abuse Group and Nomentioning

confidence: 99%

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Relationship between the COMT-Val158Met and BDNF-Val66Met Polymorphisms, Childhood Trauma and Psychotic Experiences in an Adolescent General Population Sample

Prock¹

2015

Holistic Perspectives on Trauma

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Background. Major depressive disorder (MDD) neural underpinnings may differ based on onset age and childhood trauma. We assessed cortical thickness in patients who differed in age of MDD onset and examined trauma history influence. Methods. Adults with MDD ( = 36) and controls (HC; = 18) underwent magnetic resonance imaging. Twenty patients had MDD onset <24 years of age (pediatric onset) and 16 had onset >25 years of age (adult onset). The MDD group was also subdivided into those with ( = 12) and without ( = 19) physical and/or sexual abuse as assessed by the Childhood Trauma Questionnaire (CTQ). Cortical thickness was analyzed with FreeSurfer software. Results. Thicker frontal pole and a tendency for thinner transverse temporal cortices existed in MDD. The former was driven by the pediatric onset group and abuse history (independently), particularly in the right frontal pole. Inverse correlations existed between CTQ scores and frontal pole cortex thickness. A similar inverse relation existed with left inferior and right superior parietal cortex thickness. The superior temporal cortex tended to be thinner in pediatric versus adult onset groups with childhood abuse. Conclusions. This preliminary work suggests neural differences between pediatric and adult MDD onset. Trauma history also contributes to cytoarchitectural modulation. Thickened frontal pole cortices as a compensatory mechanism in MDD warrant evaluation.

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Depressive symptom severity is associated with increased cortical thickness in older adults

Szymkowicz

McLaren

Kirton

et al. 2015

Int J Geriatr Psychiatry

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Objective Structural neuroimaging studies in older adults have consistently shown volume reductions in both major and subthreshold depression. Cortical thickness, another measure of brain structure, has not been well studied in this population. We examined cortical thickness in older adults across a range of depressive symptom (DS) severity. Methods Forty-three community-dwelling older adults (mean age = 68.80±7.00) underwent magnetic resonance imaging. Based on a priori hypotheses, we examined cortical thickness in regions of interest (ROIs) in the rostral anterior cingulate, orbitofrontal cortex, middle frontal gyrus and isthmus cingulate using multiple linear regressions with depression questionnaire scores as the independent variable and age, sex, and mean hemispheric thickness as covariates. We also performed an exploratory whole-brain vertex-wise analysis. Results After correction for multiple comparisons, we found an association between increased DSs and greater cortical thickness in the right isthmus cingulate [F(1, 38) = 8.09, FDR-corrected p = .028; R2 = 35.78] in the ROI analysis and in the left precuneus (cluster size = 413, p = 0.00002) in the vertex-wise analysis. Conclusions Older adults with higher DSs also have greater cortical thickness in the isthmus cingulate and precuneus, areas import for emotion regulation and self-referential processing. Additional research is needed to elucidate the mechanisms and potential clinical significance underlying this relationship.

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Changes in cortical thickness across the lifespan in major depressive disorder

Cited by 61 publications

References 47 publications

Cortical Thickness in Individuals at High Familial Risk of Mood Disorders as They Develop Major Depressive Disorder

Cortical Thickness in Individuals at High Familial Risk of Mood Disorders as They Develop Major Depressive Disorder

Relationship between the COMT-Val158Met and BDNF-Val66Met Polymorphisms, Childhood Trauma and Psychotic Experiences in an Adolescent General Population Sample

Depressive symptom severity is associated with increased cortical thickness in older adults

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