Changes in Components, Glycyrrhizin and Glycyrrhetinic Acid, in Raw<i>Glycyrrhiza uralensis</i>Fisch, Modify Insulin Sensitizing and Insulinotropic Actions

Ko, Byoung‐Seob; Jang, Jin Sun; Hong, Sang Mee; Sung, So Ra; Lee, Ji Eun; Lee, Mi Young; Jeon, Won Kyung; Park, Sunmin

doi:10.1271/bbb.60533

Cited by 54 publications

(28 citation statements)

References 31 publications

(52 reference statements)

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“…In addition, they induced mRNA levels of insulin receptor substrate-2, pancreas duodenum homeobox-1, and glucokinase in the islets, which contributed to improve beta-cell viability [36] .…”

Section: Radix Glycyrrhizae (Fabaceae)mentioning

confidence: 99%

An overview on antidiabetic medicinal plants having insulin mimetic property

Patel

Prasad

Kumar

et al. 2012

Asian Pacific Journal of Tropical Biomedicine

650

379

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“…In addition, they induced mRNA levels of insulin receptor substrate-2, pancreas duodenum homeobox-1, and glucokinase in the islets, which contributed to improve beta-cell viability [36] .…”

Section: Radix Glycyrrhizae (Fabaceae)mentioning

confidence: 99%

An overview on antidiabetic medicinal plants having insulin mimetic property

Patel

Prasad

Kumar

et al. 2012

Asian Pacific Journal of Tropical Biomedicine

650

379

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“…Previous studies of traditional Chinese medicines have found that tianhuafen (Radix Trichosanthis) [16] , gegen (Radix Puerariae) [17], maimendong (Radix Ophiopogonis) [18], rougui (Cortex Cinnamomi) [19, 20], huangbai (Cortex Phellodendri) [21] and aconitum (Aconitum carmichaeli) [22] may have antidiabetic activity, and dihuang (Radix Rehmanniae) [23] , shanzhuyu (Fructus Corni) [24], renshen (Radix Ginseng) [25], gancao (Radix Glycyrrhizae Praeparata) [26], and bitter orange (Aurantii Fructus) [27] have been suggested to increase insulin secretion. Unfortunately, evidence obtained in human studies is limited regarding patterns of use of classical traditional Chinese medicine (TCM) in relation to type 2 diabetes, which seem to be an area in which complementary and alternative medicines have recently grown in popularity.…”

Section: Introductionmentioning

confidence: 99%

Prescription Pattern of Chinese Herbal Products for Diabetes Mellitus in Taiwan: A Population-Based Study

Huang

Tsai²,

Lai

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Background. Traditional Chinese medicine (TCM), when given as a therapy for symptom relief, has gained widespread popularity among diabetic patients. The aim of this study is to analyze the utilization of TCM among type 2 diabetic patients in Taiwan. Methods. The use of TCM for type 2 diabetic patients were evaluated using a randomly sampled cohort of 1,000,000 beneficiaries recruited from the National Health Insurance Research Database. Results. Overall, 77.9% (n = 31,289) of type 2 diabetic patients utilized TCM and 13.9% (n = 4,351) of them used TCM for the treatment of type 2 diabetes. Among the top ten most frequently prescribed herbal formulae, four remedies, Zhi-Bo-Di-Huang-Wan, Qi-Ju-Di-Huang-Wan, Ji-Sheng-Shen-Qi-Wan and Ba-Wei-Di-Huang-Wan are derivative formulae of Liu-Wei-Di-Huang-Wan. In other words, Liu-Wei-Di-Huang-Wan and its derivatives were found to be the most common herbal formulae prescribed by TCM doctors for the treatment of diabetes in Taiwan. Conclusion. Although some evidence does support the use TCM to treat diabetes, the results from the current study may have been confounded by placebo effect, which emphasize the need for well conducted, double-blind, randomized, placebo-controlled studies in order to further evaluate the efficacy of Liu-Wei-Di-Huang-Wan on patients with type 2 diabetes.

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“…In TCM, Radix Glycyrrhizae functions by enriching qi and invigorating the stomach and spleen, moistening the lung and clearing away phlegm, clearing away heat and toxins and relieving spasm and alleviating pain. Roasted Glycyrrhizae Radix , containing glycyrrhetinic acid (GA), improves glucose tolerance better than raw Glycyrrhizae Radix extract by enhancing insulinotropic action in partially pancreatectomized diabetic mice [60]. Glycyrin, one of the main PPAR‐ γ ligands of licorice, significantly lowers the blood glucose level [61].…”

mentioning

confidence: 99%

Diabetes is an inflammatory disease: evidence from traditional Chinese medicines

Xie

2011

Diabetes, Obesity and Metabolism

272

182

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Diabetes is usually associated with inflammation. Inflammation contributes to the development of diabetes. Traditional Chinese medicines (TCM) play an important role in lowering blood glucose and controlling inflammation. Many studies show that TCM with hypoglycaemic effects, for example Radix Astragali, Radix Rehmanniae, Radix Trichosanthis, Panax Ginseng, Fructus Schisandrae, Radix Ophiopogonis, Rhizoma Anemarrhenae, Radix Puerariae, Fructus Lycii, Poria, Rhizoma Coptidis, Rhizoma Dioscoreae, Rhizoma Polygonati, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae, Semen Trigonellae, Momordica charantia, Allium sativum, Opuntia stricta, Aloe vera, Cortex Cinnamomi, Rhizoma Curcumae Longae, and so on, have nearly independent anti-inflammatory action. Antihyperglycaemic compounds, for example berberine, puerarin, quercetin, ferulic acid, astragaloside IV, curcumin, epigallocatechin gallate, resveratrol, tetrandrine, glycyrrhizin, emodin and baicalin, used in TCM also have anti-inflammatory effects. These studies suggest that TCM might exert hypoglycaemic effects that are partly mediated by the anti-inflammatory mechanisms. However, small amounts of TCM with potent anti-inflammatory action does not have any hypoglycaemic effect. This indirectly indicates that diabetes may be a low-grade inflammatory disease and potent regulation of inflammatory mediators may not be required. Studies of TCM add new evidences, which indicate that diabetes may be an inflammatory disease and slight or moderate inhibition of inflammation might be useful to prevent the development of diabetes. Through this review, we aim to develop more perspectives to indicate that diabetes may be an inflammatory disease and diverse TCM may share a common antidiabetic property: anti-inflammatory action. Further studies should focus on and validate inflammation-regulating targets of TCM that may be involved in inhibiting the development of diabetes.

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Changes in Components, Glycyrrhizin and Glycyrrhetinic Acid, in RawGlycyrrhiza uralensisFisch, Modify Insulin Sensitizing and Insulinotropic Actions

Cited by 54 publications

References 31 publications

An overview on antidiabetic medicinal plants having insulin mimetic property

An overview on antidiabetic medicinal plants having insulin mimetic property

Prescription Pattern of Chinese Herbal Products for Diabetes Mellitus in Taiwan: A Population-Based Study

Diabetes is an inflammatory disease: evidence from traditional Chinese medicines

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