Changes in Circulating MicroRNAs Are Associated With Childhood Obesity

Prats‐Puig, Anna; Ortega, Francisco; Mercader, Josep M.; Moreno-Navarrete, José María; Moreno, María; Bonet, Núria; Ricart, Wifredo; López‐Bermejo, Abel; Fernández-Real, José Manuel

doi:10.1210/jc.2013-1496

Cited by 195 publications

(183 citation statements)

References 20 publications

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“…Previous studies have shown that some differentially and abundantly expressed miRNAs (down-regulated miRNAs: ssc-let-7i, ssc-miR-21, ssc-miR-27b-3p and up-regulated miRNAs: ssc-miR-1, ssc-miR-133a-3p, ssc-miR-486) were responsible for regulating adipogenic differentiation [36][37][38][41][42][43]. ssc-miR-1 and ssc-miR133a were found extensively in skeletal muscle tissues while ssc-miR-21, ssc-miR-27b-3p, and the Let-7 family play important roles in adipomuscle and myocardial tissue.…”

Section: Discussionmentioning

confidence: 99%

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WITHDRAWN: An integrated analysis of microRNAs involved in fat deposition in different pig breeds

Zhang¹,

Huang²,

Guo³

et al. 2017

Oncotarget

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The domestic pig, an important species in the animal production industry, is also a model system for studying fat deposition and fat-associated diseases in humans. In order to investigate the genetic relationships of the miRNAs that may regulate fat deposition, we performed a genome-wide analysis of miRNAs derived from subcutaneous adipose tissue of Laiwu and Large White pig using RNA-seq. A total of 26,486,906 reads were obtained. Further analysis indicated that 39 known miRNAs and 56 novel miRNAs had significantly differential expression between the two breeds of pigs. Gene Ontology and KEGG pathway analysis revealed that the predicted targets of these differentially expressed miRNAs were involved in several fat-associated pathways, such as the PPAR, MAPK and Wnt signaling pathways. In addition, we found that three miRNAs, ssc-miR-133a-3p, ssc-miR-486 and ssc-miR-1, had an impact on the development of porcine subcutaneous fat through the PPAR signaling pathway. This study provides clues to understand the potential mechanisms of adipogenesis and fat deposition between two different pig breeds. Furthermore, these results may also contribute to the research involving human obesity.

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Section: Discussionmentioning

confidence: 99%

“…Therefore, ssc-miR-1 and ssc-miR-133a may increase lipometabolism in pigs. In addition, the concentration of miR-486 in the serum is correlated with T2DM and obesity, and miR-486, as a circulating miRNA, may be related with metabolic disorders [43]. Thus, the up-regulation of ssc-miR-486 in Laiwu pigs may be a potential biomarker of obesity.…”

Section: Discussionmentioning

confidence: 99%

WITHDRAWN: An integrated analysis of microRNAs involved in fat deposition in different pig breeds

Zhang¹,

Huang²,

Guo³

et al. 2017

Oncotarget

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“…Soon thereafter, the first study on circulating miRNAs in the context of pediatric obesity was published by the same group [48]. Also performing Taqman array analysis, Prats-Puig et al [48] profiled the circulating miRNAs in prepubertal children.…”

Section: Circulating Mirna In Obesitymentioning

confidence: 99%

Functional Significance and Predictive Value of MicroRNAs in Pediatric Obesity: Tiny Molecules with Huge Impact?

et al. 2016

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Obesity is a major health concern. While some children develop comorbidities such as insulin resistance and low-grade systemic inflammation upon weight gain, others stay metabolically healthy. There is an urgent need for clinically relevant markers with prognostic value related to disease development and intervention success. MicroRNAs (miRNAs) are established biomarkers for several disease states. Herein, we give a brief overview of miRNA biogenesis and function and the potential role of circulating miRNA in the context of pediatric obesity.

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“…Urine [29], PBMC [1,2] Bladder Cancer (Urine) [30], PD (PBMC) [35], HF, CAD (Plasma) [20], Lung Cancer (Plasma) [26] T2D Plasma [4,7,12,15,[18][19][20]49], PBMC [2] AMI (Plasma, Serum) [4,36], Congestive HF (Plasma) [4], SLE (Plasma) [10] GD PBMC [2] miR-126* T1D PBMC [2] PD (PBMC) [35], CAD (Plasma, Plasma MPs) [23] miR-130a T1D PBMC [2] HF (Plasma) [23], Autism (Serum) [47] Arteriosclerosis (Serum) [4,16], Hypertension (Blood) [32] miR-132 GD Serum [4,18,41] AD (Plasma) [5], Rheumatic Arthritis (Plasma) [10], Obesity (Blood) [7] miR-140 T1D PBMC [1] CAD (Blood) [16,20,23], Obesity (Plasma) [22], Crohn's Disease (Serum) [10] T2D PBMC [2] Childhood Obesity, Morbid Obesity (Plasma) [47] miR-142 T1D PBMC [2] Cardiomyopathy (PBMC) [16,23], Obesity (Plasma) [22], Prepubertal Obesity (Plasma) [37] T2D PBMC [2] HF (Plasma) [23], SLE (Plasma) [10]…”

Section: T1dmentioning

confidence: 99%

“…Moreover, miRNAs have been reported to regulate the expression of VEGF (vascular endothelial growth factor) in the retina and to participate to the development of diabetic retinopathy [36]. Kovacs et al identified a set of up-regulated NF-κB-responsive miRNAs in the retina of diabetic rats, including miR-146a/b, miR-155, miR-132 and miR-21 [37]. MiR-155 is known to be involved in immuno-modulatory signaling, whereas miR-21 and mir146a/b participate to fibrotic responses and miR-132 to angiogenesis.…”

mentioning

confidence: 99%

Therapeutic potential of miRNAs in diabetes mellitus

Henaoui

Stoll

Tugay

et al. 2014

Expert Review of Endocrinology & Metabolism

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SummaryMicroRNAs are major regulators of gene expression that are emerging as central players in the development of many human diseases, including diabetes mellitus. In fact, diabetes manifestation is associated with alterations in the microRNA profile in insulin-secreting cells, insulin target tissues and, in case of long-term diabetes complications, in many additional organs. Diabetes results also in changes in the profile of microRNAs detectable in blood and other body fluids. This has boosted an ever increasing interest in the use of circulating microRNAs as potential biomarkers to predict the development of diabetes and its devastating complications. Moreover, promising approaches to correct the level of selected microRNAs are emerging, permitting to envisage new therapeutic strategies to treat diabetes and its complications.Key words: Diabetes mellitus; Insulin; pancreatic islet; microRNA; Gene expression; biomarker; diabetic complication; Adeno-associated virus 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 of target mRNAs that are initially recognized through base pairing to a conserved "seed" sequence corresponding to nucleotides 2-8 of the miRNAs, leading to inhibition of mRNA translational and/or to a decrease in messenger stability [2, 3]. A single miRNA typically controls hundreds of targets and each mRNA can be targeted by different miRNAs, conferring to this class of non-coding RNA molecules a huge regulatory potential [4]. In the past decade, a large body of evidence has been accumulated pointing to a role for miRNAs in the etiology and pathogenesis of diabetes and its complications. Indeed, alterations in the level of these non-coding RNAs has been observed both in insulin-secreting cells and in insulin-target tissues isolated from diabetes animal models or diabetic patients [5]. Moreover, changes in miRNA expression have been associated with long-term diabetes complications including neuropathy, retinopathy, renal failure and macrovascular diseases. Page 1 of 36 Expert Review of Endocrinology & MetabolismThe first demonstration of the involvement of miRNAs in the control of specialized β-cell functions has been provided ten years ago by Poy et al. who showed that inappropriate levels of miR-375, one of the most abundant miRNAs present in β-cells, can affect insulin secretion [6]. Later on, this and several other miRNAs including miR-15a/b, miR-16, miR-195, miR-503, miR-451, miR-214, miR-9, miR-124a, miR-7 and miR-376 were demonstrated to play important roles in the differentiation of pancreatic islet cells [7][8][9][10][11][12]. Moreover, changes in the levels of many miRNAs, including miR-9, miR...

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Changes in Circulating MicroRNAs Are Associated With Childhood Obesity

Abstract: This study provides the first evidence that circulating miRNAs are deregulated in prepubertal obese children. Thus, the very early detection of an abnormal circulating miRNA profile may be a promising strategy to identify obese children who may suffer from metabolic abnormalities.

Cited by 195 publications

References 20 publications

WITHDRAWN: An integrated analysis of microRNAs involved in fat deposition in different pig breeds

WITHDRAWN: An integrated analysis of microRNAs involved in fat deposition in different pig breeds

Functional Significance and Predictive Value of MicroRNAs in Pediatric Obesity: Tiny Molecules with Huge Impact?

Therapeutic potential of miRNAs in diabetes mellitus

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