Changes in circuIating B cells and immunoglobulin cIasses and subcIasses in a healthy aged popuIation

Paganelli, Roberto; Quinti, Isabella; Fagiolo, U; Cossarizza, Andrea; Ortolani, Claudio; Guerra, Emanuele; Sansoni, Paolo; Lp, Pucillo; Scala, Enrico; Cozzi, Emanuele; Bertollo, L; Monti, Daniela; Franceschi, Claudio

doi:10.1111/j.1365-2249.1992.tb07954.x

Cited by 145 publications

(51 citation statements)

References 18 publications

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“…This finding was however restricted to subjects with no history of previous exposure to this vaccine (Gibson et al, 2012) suggesting that the influence of increasing fruit and vegetable intake may target naïve B cells rather than antigen experienced memory B cells. This finding may be related to the observation that serum levels of IgG2 increase with age, and that IgG2 is produced against polysaccharide antigens required for defence against bacteria such as pneumococci (Paganelli et al, 1992).…”

Section: Carotenoidsmentioning

confidence: 91%

Nutrition, diet and immunosenescence

Maijó

Clements

Ivory

et al. 2014

Mechanisms of Ageing and Development

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Ageing is characterized by immunosenescence and the progressive decline in immunity in association with an increased frequency of infections and chronic disease. This complex process affects both the innate and adaptive immune systems with a progressive decline in most immune cell populations and defects in activation resulting in loss of function. Although host genetics and environmental factors, such as stress, exercise and diet can impact on the onset or course of immunosenescence, the mechanisms involved are largely unknown. This review focusses on identifying the most significant aspects of immunosenescence and on the evidence that nutritional intervention might delay this process, and consequently improve the quality of life of the elderly. We would like to thank the reviewers for their careful review of our manuscript, which has been revised accordingly. Below, we have provided a point-by-point reply to the issues raised: AbstractAgeing is characterized by immunosenescence and the progressive decline in immunity in association with an increased frequency of infections and chronic disease. This complex process affects both the innate and adaptive immune systems with a progressive decline in most immune cell populations and defects in activation resulting in loss of function. Although host genetics and environmental factors, such as stress, exercise and diet can impact on the onset or course of immunosenescence, the mechanisms involved are largely unknown. This review focusses on identifying the most significant aspects of immunosenescence and on the evidence that nutritional intervention might delay this process, and consequently improve the quality of life of the elderly.

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Section: Carotenoidsmentioning

confidence: 91%

Nutrition, diet and immunosenescence

Maijó

Clements

Ivory

et al. 2014

Mechanisms of Ageing and Development

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show abstract

“…This is in agreement with previous data that have demonstrated a reduction of IgM ''only'' memory B cells in the elderly (Shi et al 2005). We show a slight increase in the expression of IgG and IgA on switched memory B cells but this did not reach significance, although the relative proportions of the different isotypes of memory cells mirrors the relative proportion of serum immunoglobulin of the different isotypes (Paganelli et al 1992;Listì et al 2006).…”

Section: Surface Immunoglobulin Of Dn Cellsmentioning

confidence: 91%

B cell immunosenescence: different features of naive and memory B cells in elderly

et al. 2011

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Elderly people show a reduced protection against new infections and a decreased response to vaccines as a consequence of impairment of both cellular and humoral immunity. In this paper we have studied memory/naïve B cells in the elderly, evaluating surface immunoglobulin expression, production of the pro-and anti-inflammatory cytokines, tumor necrosis factor (TNF)-a and interleukin (IL)-10, and presence of somatic hypermutation, focusing on the IgG ? IgD -CD27 -double negative (DN) B cells that are expanded in the elderly. Our results show that naïve B cells from young donors need a sufficiently strong stimulus to be activated ''in vitro'', while naïve B cells from old subjects are able to produce IL-10 and TNF-a when stimulated ''physiologically'' (a-CD40/IL-4), suggesting that these cells might play a role in the control of the immuno-inflammatory environment in the elderly. In addition, in the elderly there is an accumulation of DN B cells with a reduced rate of somatic hypermutation. Thus, DN B lymphocytes may be exhausted cells that are expanded and accumulate as a by-product of persistent stimulation or impaired germinal center formation.

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“…In contrast to mouse model, in humans there is a decrease both in percentage and absolute number of total CD19 + B lymphocytes (Veneri et al, 2009;Faria et al, 2008;Frasca et al, 2008;Shi et al, 2005;Chong et al, 2005;Colonna Romano et al, 2003Breitbart et al, 2002;Huppert et al, 1998;Wikby et al, 1994;Paganelli et al, 1992). Moreover, it has been demonstrated that absolute number of B cell precursors in the bone marrow declines with age and particularly during adolescence (McKenna et al, 2001), however, B lymphopoiesis persists throughout adult life (Rossi et al, 2003).…”

Section: B Lymphocytesmentioning

confidence: 99%

B cells and immunosenescence: A focus on IgG+IgD−CD27− (DN) B cells in aged humans

Bulati¹,

Buffa²,

Candore³

et al. 2011

Ageing Research Reviews

101

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a b s t r a c tImmunosenescence contributes to the decreased ability of the elderly to control infectious diseases, which is also reflected in their generally poor response to new antigens and vaccination. It is known that the T cell branch of the immune system is impaired in the elderly mainly due to expansion of memory/effector cells that renders the immune system less able to respond to new antigens. B lymphocytes are also impaired in the elderly in terms of their response to new antigens. In this paper we review recent work on B cell immunosenescence focusing our attention on memory B cells and a subset of memory B cells (namely IgG + IgD − CD27 − ) that we have demonstrated is increased in healthy elderly.

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Changes in circuIating B cells and immunoglobulin cIasses and subcIasses in a healthy aged popuIation

Cited by 145 publications

References 18 publications

Nutrition, diet and immunosenescence

Nutrition, diet and immunosenescence

B cell immunosenescence: different features of naive and memory B cells in elderly

B cells and immunosenescence: A focus on IgG+IgD−CD27− (DN) B cells in aged humans

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