Changes in Circadian Variations in Blood Pressure, Pain Pressure Threshold and the Elasticity of Tissue after a Whole-Body Photobiomodulation Treatment in Patients with Fibromyalgia: A Tripled-Blinded Randomized Clinical Trial

Navarro-Ledesma, Santiago; Carroll, James D.; González-Muñoz, Ana; Pruimboom, Leo; Burton, Patricia

doi:10.3390/biomedicines10112678

Cited by 14 publications

(18 citation statements)

References 48 publications

(51 reference statements)

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“…Current research shows promising short-term results of whole-body PBM on fibromyalgia sufferers, however, the long-term results are still to be explored [ 6 , 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…The treatment of superficial tissue uses wavelengths in the range of 600 to 700 nm, while the treatment of deeper tissue uses wavelengths in the range of 780 to 950 nm [ 1 , 2 ]. Currently, whole-body PBM has shown a systemic response in addition to the local response, with improvements in quality of life, pain, sleep disorders, tiredness, muscle spasm, morning stiffness, psychological factors, elastic properties of tissue, circadian rhythms, tender points, and in fibromyalgia sufferers [ 3 , 4 , 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of Photobiomodulation Therapy in the Treatment of Pain and Inflammation: A Literature Review

et al. 2023

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The main objective of this literature review was to analyze the efficacy of (PBM) therapy application on subjects with chronic pain and inflammation, and furthermore, to evaluate the methodological quality of the collected literature. The search was conducted using five databases: PubMed, ProQuest, Scopus, Web of Science, and PEDro. The keywords “low level laser therapy”, “chronic pain”, and “inflammation” provided the selection of RCTs that were published within the last 5 years, conducted in humans, and written in English. The PEDro Internal Validity Scale (IVS) checklist was used to evaluate the risk of bias in the included studies. A total of 11 articles were selected, all of them RCTs. Of the articles, five showed that PBM positively influences chronic pain, while another showed the same but only in the short term. In two other articles, the patient’s inflammation improved markedly. In one article there was no improvement in chronic pain and in another, there was no improvement in inflammation. Four articles demonstrated that PBM is beneficial in acute pain. Furthermore, six studies were given an “excellent” score and the remaining five a “good” score based on the IVS. Photobiomodulation has beneficial effects on chronic pain and inflammation, although more research needs to be completed in this line for this to be clarified as the existence of RCTs on this subject is limited.

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“…Current research shows promising short-term results of whole-body PBM on fibromyalgia sufferers, however, the long-term results are still to be explored [ 6 , 7 ].…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Efficacy of Photobiomodulation Therapy in the Treatment of Pain and Inflammation: A Literature Review

et al. 2023

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“…A study evaluating whole-body PBMT in a group of female athletes resulted in better quality sleep and therefore reduction in quantity of sleep, even after higher training loads [104]. Augmented autonomic profiles seen after whole-body PBMT [96,104] has implications on sleep quality and vice versa [125,139].…”

Section: Discussionmentioning

confidence: 99%

Whole-Body Photobiomodulation Therapy for Fibromyalgia: A Feasibility Trial

Fitzmaurice

Heneghan

Rayen

et al. 2023

Preprint

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Effective treatment for fibromyalgia (FM) is lacking and further treatment options are needed. Photobiomodulation therapy (PBMT) represents one potential treatment option. Whilst favourable findings have been reported using localised PBMT, no investigations have established the value of whole-body PBMT for the complete set of symptom domains in FM. A single-arm feasibility study was conducted in accordance to CONSORT guidelines. A non-probability sampling method was used to access individuals with FM. The primary outcome measure was identified as the Revised Fibromyalgia Impact Questionnaire (FIQR). Forty-nine participants were screened and 21 trial participants entered the trial. Nineteen participants completed the intervention (18 whole-body PBMT sessions over approximately six weeks). Descriptive statistics and qualitative analysis was undertaken to represent feasibility outcomes. Acceptability of the trial device and processes were established. Outcome measures towards efficacy data were guided by core and peripheral OMERACT domains, utilising a combination of participant-reported and performance-based outcome measures. Positive changes were observed for FM-specific quality of life, pain, tenderness, stiffness, fatigue, sleep disturbance, anxiety, depression and cognitive impairment. Patient global assessment revealed improvements at 6 weeks, with continued effect at 24 weeks. FM-specific quality of life at 24 weeks remained improved compared with baseline scores. Data for the embedded qualitative component of the trial were captured by participant-reported experience measures and audio-recorded semi-structured interviews. Findings provide evidence to support a full-scale trial and shows promise regarding potential efficacy of this novel non-invasive treatment in an FM population.

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“…For this reason, a comparison of our results with other studies is difficult. It is well known that as a consequence of an altered central nervous system, patients with FM exhibit neurovegetative symptoms and both central and peripheral sensitisation, as well as irritable bowel syndrome and the affected gynaecological area, chronic fatigue syndrome, postural orthostatic tachycardia, variations in circadian blood pressure or an excessive response to stimuli such as auditory, cold or mental stress [ 2 , 10 , 11 , 20 , 36 ]. Furthermore, the continuation of pain and symptoms leads to depression and affects mental health [ 37 , 38 ].…”

Section: Discussionmentioning

confidence: 99%

“…Even though the origin of FM remains unknown, current evidence defines it as a central sensitisation syndrome which involves an alteration in the hypothalamic–pituitary axis (HPA). Hence, ascending and descending pain pathways, as well as neurotransmitters, can be altered, which could be the cause of increased pain responses and the altered circadian variations in blood pressure in patients suffering from FM [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Do Psychological Factors Influence the Elastic Properties of Soft Tissue in Subjects with Fibromyalgia? A Cross-Sectional Observational Study

et al. 2022

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Nowadays, there is evidence related to the impact that psychological factors have on symptoms, specifically vegetative ones, and on the autonomic nervous system in patients with fibromyalgia (FM). However, there are no studies to correlate the level of association between psychological factors and the elastic properties of tissue in the FM population. Elastic properties of soft tissue reflect age- and disease-related changes in the mechanical functions of soft tissue, and mechanical failure has a profound impact on morbidity and mortality. The study has a cross-sectional observational design with 42 participants recruited from a private clinic and rehabilitation service. The Pain Catastrophizing Scale, Tampa Kinesiophobia Scale and Self-Efficacy Scale were used to assess psychological factors. The elastic properties of the tissue in the characteristic painful points, which patients suffering from FM described, were assessed by strain elastography. A low and significant level of association was found between pain catastrophising scale (PCS) and the non-dominant lateral epicondyle (r = −0.318; p = 0.045). Kinesiophobia was found to be related to the dominant lateral epicondyle (r = 0.403; p = 0.010), the non-dominant knee (r = −0.34; p = 0.027) and the dominant forearm (r = 0.360; p = 0.010). Self-Efficacy showed a low level of association with the non-dominant supraspinatus (r = −0.338; p = 0.033) and the non-dominant medial epicondyle (r = −0.326; p = 0.040). Psychological factors and the elastic properties of tissue seem to be associated in patients suffering from FM. The most profound association between psychological factors and non-dominant parts of the body could be related to neglect and non-use of those parts of the body.

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Changes in Circadian Variations in Blood Pressure, Pain Pressure Threshold and the Elasticity of Tissue after a Whole-Body Photobiomodulation Treatment in Patients with Fibromyalgia: A Tripled-Blinded Randomized Clinical Trial

Cited by 14 publications

References 48 publications

Efficacy of Photobiomodulation Therapy in the Treatment of Pain and Inflammation: A Literature Review

Efficacy of Photobiomodulation Therapy in the Treatment of Pain and Inflammation: A Literature Review

Whole-Body Photobiomodulation Therapy for Fibromyalgia: A Feasibility Trial

Do Psychological Factors Influence the Elastic Properties of Soft Tissue in Subjects with Fibromyalgia? A Cross-Sectional Observational Study

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