Abstract:Purpose To evaluate and determinate changes in the circadian rhythms related to retinal degeneration in P23H line 1 rats.
Methods Male rats homozygous for the P23H rhodopsin mutation line 1 and male SD rats were evaluated during a 12 months period. All of them were individually housed and maintained during this time under controlled humidity (60%), temperature (23 ± 1°C) and under a 12‐h light/dark cycle. Locomotor activity (LA) was monitored throughout the experiment by an intraperitoneal transmitter. Electro… Show more
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