Changes in choroidal blood flow and choroidal thickness after treatment in two cases of pediatric anisohypermetropic amblyopia

Abstract

PurposeWe aimed to examine the changes in choroidal blood flow (CBF) and central choroidal thickness (CCT) in children with anisohypermetropic amblyopia using laser speckle flowgraphy (LSFG) and enhanced depth imaging optical coherence tomography (EDI-OCT).ObservationsThe patients were both 6-year-old Japanese male children with complaints of worsening right visual acuity and were diagnosed with anisohypermetropic amblyopia. The decimal best-corrected visual acuities (BCVAs) in cases 1 and 2 were both 0.5. In both cases, LSFG results demonstrated CBF impairment in amblyopic eyes compared with fellow eyes. EDI-OCT results also showed that the CCTs of amblyopic eyes were greater than those of fellow eyes at the initial visit. Several months after the first visit, the decimal BCVAs in both cases had improved to 1.0 because of treatment. Further, the CBF gradually increased along with a decrease in the CCT of the amblyopic eye. The axial lengths and spherical powers of the amblyopic eyes in the two cases were not different during follow-up.Conclusions and importanceWe have determined the changes in CBF and CCT in two children with anisohypermetropic amblyopia for the first time. CBF impairments may be involved in the pathogenesis of anisohypermetropic amblyopia, and LSFG may be useful in examining CBF in pediatric anisohypermetropic amblyopia.

Changes in choroidal circulation and pulse waveform in a case of pregnancy-induced hypertension with serous retinal detachment

“…14 OPP was calculated from measurements of the patient's IOP and blood pressure, as described earlier. 7 , 8 …”

“…Laser speckle flowgraphy (LSFG-NAVI®, Softcare Co. Ltd., Fukuoka, Japan) is a non-invasive quantitative method that is very useful for measuring and assessing choroidal blood flow (CBF) 7 , 8 and pulse waveforms 9 based on the changes in the speckle pattern of the reflection of laser light from the fundus photo. 10 The mean blur rate (MBR) is a parameter of blood flow speed.…”

Comparison of Optic Nerve Head Blood Flow Autoregulation among Quadrants Induced by Decreased Ocular Perfusion Pressure during Vitrectomy

“…Recent studies have shown that the MBR in the ONH measured using LSFG was significantly correlated with actual ONH blood flow measured using the microsphere method in monkey eyes [ 25 ] and using the hydrogen gas clearance method in rabbits [ 26 , 27 ]. Furthermore, LSFG is a useful devise to examine the blood flow in the ONH [ 19 – 27 ], retinal vessels [ 28 – 30 ], and choroid [ 31 – 34 ].…”

Conceptualización integral de la ambliopía

“…Cabe destacar que esta ambliopía por deprivación podría ser la más perniciosa y de difícil tratamiento. Dentro de esta, las principales causas de privación sensorial son las cataratas y las opacidades corneales (33).…”