Changes in children's fatigue during the course of treatment for paediatric cancer

Perdikaris, Pantelis; Merkouris, Anastasios; Patiraki, Elisabeth; Papadatou, Danai; Vasilatou-Kosmidis, Helen; Matziou, Vasiliki

doi:10.1111/j.1466-7657.2008.00644.x

Cited by 33 publications

(29 citation statements)

References 31 publications

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“…anemia) 34 and symptoms. 7,32,35 Our findings, in conjunction with those of others, underscore the complex and multifactorial nature of fatigue.…”

Section: Discussionsupporting

confidence: 80%

“…The mechanism by which a child with a high burden of other symptoms is more likely to experience fatigue distress is not well understood but has been previously described. 35 Suffering from a different symptom may reduce a child’s threshold for experiencing fatigue distress (and vice versa). Treatment of other symptoms (i.e.…”

Section: Discussionmentioning

confidence: 99%

“…Third, the MSAS permitted a deeper examination of the symptom, fatigue’s various dimensions and the burden experienced by the child, which are not one and the same. 35,45 Finally, we evaluated fatigue and fatigue distress in a comprehensive manner, evaluating an array of child, clinical and symptom factors together, as a child would experience them, to better understand the nature of pediatric advanced cancer fatigue.…”

Section: Discussionmentioning

confidence: 99%

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Self‐reported fatigue in children with advanced cancer: Results of the PediQUEST study

Ullrich

Dussel

Orellana

et al. 2018

Cancer

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Background Pediatric cancer-related fatigue is prevalent and significantly impairs health-related quality of life, yet its patterns and correlates are poorly understood. We aimed to describe fatigue prospectively reported by children with advanced cancer, and to identify factors associated with fatigue and associated distress. Methods Children (≥2 years) with advanced cancer (N=104) or a parent at three academic hospitals reported their symptoms at most weekly, over nine months, using the computer-based Pediatric Quality of Life Evaluation of Symptoms Technology (PediQUEST) system. PediQUEST administered a modified version of the Memorial Symptom Assessment Scale (PQ-MSAS) as part of a randomized controlled trial. Clinical information was abstracted from medical records. Primary outcomes were 1) fatigue prevalence (yes/no response to PQ-MSAS fatigue item) and 2) fatigue distress (composite score of severity, frequency and bother). Multivariable models were constructed to identify factors independently associated with fatigue prevalence and scores reflecting fatigue distress (i.e., burden). Results Of 920 reports, 46% (n=425) noted fatigue. When reported, fatigue was of high frequency in 41% (n=174), severity in 25% (n=107) and bother in 34% (n=143). Most reports (84%, n=358) were associated with scores indicating fatigue distress. In multivariable analyses, fatigue was associated with older age, lower hemoglobin and distress from particular symptoms (anorexia, nausea, sleep disturbance, sadness and irritability). In contrast, fatigue distress was associated with distress from nausea, cough and pain. Conclusions Fatigue is common among children with advanced cancer, and is often highly distressing. Interventions focused on uncontrolled symptoms may ease fatigue distress in children with advanced cancer.

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“…anemia) 34 and symptoms. 7,32,35 Our findings, in conjunction with those of others, underscore the complex and multifactorial nature of fatigue.…”

Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Self‐reported fatigue in children with advanced cancer: Results of the PediQUEST study

Ullrich

Dussel

Orellana

et al. 2018

Cancer

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“…Fatigue problems during hospitalization may be attributed to higher chemotherapy intensity and treatment related symptoms, compared with outpatient treatments (Collins, et al, 2000). Medical procedures during hospitalization such as lumbar punctures, bone marrow aspirations, and repetitive blood draws were causing pain and stress, leading to fatigue (Perdikaris et al, 2008). Adolescents reported that the hospital environment and the lack of interesting activities were the main causes of fatigue (Hockenberry-Eaton et al, 2000; Perdikaris et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Fatigue and health related quality of life in children and adolescents with cancer

Nunes

Jacob

Bomfim

et al. 2017

European Journal of Oncology Nursing

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Purpose The study examined the different dimensions of fatigue (general, sleep/rest, cognitive), health related quality of life (physical, emotional, cognitive, social), and the relationships between fatigue and HRQL in hospitalized children and adolescents with cancer in Brazil. Method Participants were recruited from a pediatric oncology inpatient unit in a comprehensive cancer care hospital in southeast Brazil. They completed the PedsQL Multidimensional Fatigue Scale and the PedsQL Inventory of Quality of Life (Generic and Cancer module) once during hospitalization. Results The majority (66.7%) of the participants (n=38; mean age 12.1 ± 2.9 years) had total fatigue scores < 75 on 0 to 100 scale; with the mean total fatigue score of 63.8 ± 18.5. The majority (72.2% generic; 83.3% cancer modules) had total PedsQL scores < 75 on 0 to 100 scale. The mean PedsQL score on generic module (61.1 ± 17.0) was similar to the mean PedsQL score cancer module (59.1 ± 16.7). Significant correlations were found between total fatigue and quality of life generic (r=0.63, p = 0.000) and cancer module (r=0.74, p = 0.000). Conclusions The study is the first to report fatigue and health related quality of life in hospitalized children and adolescents with cancer in Brazil. Similar to experiences of other children in the world, our findings indicate that children and adolescents with cancer had problems with fatigue that were associated with low HRQL. Future studies are recommended to examine interventions (exercise, leisurely activities) that may alleviate fatigue and improve HRQL in pediatric patients with cancer.

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“…The childhood fatigue scale was used to assess fatigue in 40 children (7e12 y) being treated for cancer, including chemotherapy and/or radiotherapy [78]. Children diagnosed with brain tumours were excluded.…”

Section: Fatigue In Children With Cancermentioning

confidence: 99%

Sleep and fatigue in pediatric oncology: A review of the literature

Walter

Nixon

Davey

et al. 2015

Sleep Medicine Reviews

116

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Changes in children's fatigue during the course of treatment for paediatric cancer

Abstract: Cancer treatment was found significantly to increase children's fatigue levels. Medical procedures and the hospital environment seemed to be major causative factors of the fatigue experienced by children with cancer during their treatment.

Cited by 33 publications

References 31 publications

Self‐reported fatigue in children with advanced cancer: Results of the PediQUEST study

Self‐reported fatigue in children with advanced cancer: Results of the PediQUEST study

Fatigue and health related quality of life in children and adolescents with cancer

Sleep and fatigue in pediatric oncology: A review of the literature

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