Changes in characteristics of sleep-wake cycle and motor activity at the preclinical stage of Parkinson's disease in old rats

The paper is aimed at the analysis of the role of the circadian regulation of ghrelin levels in patients with Parkinson’s disease. Based on the literature data, patients with Parkinson’s disease have clinical fluctuations in the symptoms of the disease, manifested by the diurnal changes in motor activity, autonomic functions, sleep-wake cycle, visual function, and the efficacy of dopaminergic therapy. Biological rhythms are controlled by central and peripheral oscillators which links with dopaminergic neurotransmission – core of the pathogenesis of Parkinson`s disease. Circadian system is altered in Parkinson`s disease due to that ghrelin fluctuations may be changed. Ghrelin is potential food-entrainable oscillator because it is linked with clock genes expression. In Parkinson`s disease this hormone may induce eating behavior changing and as a result metabolic disorder. The “hunger hormone” ghrelin can be a biomarker of the Parkinson’s disease, and the study of its role in the pathogenesis, as well as its dependence on the period of the day, intake of levodopa medications to improve the effectiveness of treatment is promising.

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Changes in characteristics of sleep-wake cycle and motor activity at the preclinical stage of Parkinson's disease in old rats

Abstract: Both increased drowsiness and reduced MA during sleep, reflecting dopamine deficit in the nigrostriatal system, may be recommended for using in clinical research as inexpensive early markers of the preclinical stage of PD.

Cited by 3 publications

References 24 publications

Parkinson’s Disease and Aging

Parkinson’s Disease and Aging

U-133, a Chaperone Inducer, Eliminates Sleep Disturbances in a Model of the Preclinical Stage of Parkinson’s Disease in Aged Rats

The Role of Circadian Regulation of Ghrelin Levels in Parkinson’s Disease (Literature Review)

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