Changes in cerebral metabolism detected by 18F-FDG PET-CT in a case of anti-NMDA receptor encephalitis

Ochoa-Figueroa, M.A.; Cárdenas-Negro, C.; Allende-Riera, A.; Uña-Gorospe, J.; García, D. Cabello; DeSequera-Rahola, M.

doi:10.1016/j.remnie.2012.06.012

Cited by 1 publication

(3 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PET findings in relapsing cases have demonstrated reduced FDG uptake in the cerebral cortex indicating reduced metabolic rates whereas in follow up patients who have made a good recovery FDG-PET findings were normal. This supports the theory that brain injury sustained during anti-NMDAR encephalitis is reversible [28,32].…”

Section: Investigations and Diagnosissupporting

confidence: 86%

“…These findings are not exclusive with focal cerebellar hypermetabolism and diffuse hypometabolism elsewhere has been reported as a novel finding in a paediatric case [31]. Literature proposes that further FDG-PET scanning in cases of anti-NMDAR encephalitis is warranted in order to categorise those areas of the brain most affected [28]. PET findings in relapsing cases have demonstrated reduced FDG uptake in the cerebral cortex indicating reduced metabolic rates whereas in follow up patients who have made a good recovery FDG-PET findings were normal.…”

Section: Investigations and Diagnosismentioning

confidence: 74%

“…Fluorine-18 Fluorodeoxyglucose Positron emission tomography-computed tomography ( 18 F FDG PET/CT) imaging can be performed under EEG monitoring in those patients presenting with features of anti-NMDAR encephalitis in order to confirm or rule out the presence of teratoma or any other possible sites of malignancy [27]. It is also a non invasive way in which to provide information on the functioning of the brain at a biochemical and metabolic level [28].…”

Section: Investigations and Diagnosismentioning

confidence: 99%

See 2 more Smart Citations

Anti-NMDA Receptor Encephalitis

Ferdinand¹

2013

J Clin Cell Immunol

View full text Add to dashboard Cite

In recent years, the discovery of antibodies to specific neuronal antigens that then go on to cause encephalitis has gone a long way to change the investigation and management of a potential encephalitic process. These have now become known under the umbrella term of the 'autoimmune encephalitides'. In this article we look at anti-N-methyl-D-aspartate receptor encephalitis, a condition most often found in young females and has an association with a number of malignancies, most commonly ovarian teratomas. Most patients will have a viral prodrome, followed by psychiatric, seizure, dysautonomic and dyskinetic features, but can present at any point along this pathway. Treatment involves prompt tumour identification and removal where appropriate and initiation of immunosuppressive therapy, usually commencing with corticosteroids. A substantial proportion of patients will make a full recovery, but many will need medical, psychiatric and social care following completion of the acute phase of the illness.

show abstract

Section: Investigations and Diagnosissupporting

confidence: 86%

Section: Investigations and Diagnosismentioning

confidence: 74%